OMIA 000284-9823 : Diabetes mellitus, type II in Sus scrofa

See the equivalent entry at NCBI

In other species: domestic cat , crab-eating macaque , golden hamster

Possible human homologues (MIM numbers): 125850 , 125852 , 520000

Mendelian trait/disorder: yes

Considered a defect: yes

Key mutation known: no

Species-specific description: Genetically-modifed organism; GMO

Molecular basis: Renner et al. (2010) used transgenesis of the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) to create an animal model of this human disorder due to a dominant-negative GIP receptor in pancreatic cells.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GIPR gastric inhibitory polypeptide receptor Sus scrofa 6 NC_010448.4 (52022667..52033959) GIPR Homologene, Ensembl, NCBI gene

Reference


2010 Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D.C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Göke, B., Pfeifer, A., Wanke, R., Wolf, E. :
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59:1228-38, 2010. Pubmed reference: 20185813. DOI: 10.2337/db09-0519.

Edit History


  • Created by Frank Nicholas on 31 Mar 2016
  • Changed by Frank Nicholas on 08 Aug 2017