OMIA:001201-9685 : Coat colour, orange in Felis catus (domestic cat) |
In other species: golden hamster
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: X-linked
Considered a defect: no
Key variant known: no
Species-specific name: Tortoishell; tortoiseshell
Mapping: Grahn et al. (2005) localised this locus to within 14 cM of the centromere of the X chromosome. Schmidt-Küntzel et al. (2009) refined the location to a 3.5Mb region of the q arm "between markers at positions 106 and 116.8 Mb in the [then] current 1.9x-coverage sequence assembly of the cat genome".
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001201-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Owen, R.E. : |
| Half-chromatid mutation as a possible cause of mosaic males and females in hymenoptera and rare fertile male tortoiseshell cats. Genome , 2023. Pubmed reference: 37307601. DOI: 10.1139/gen-2023-0006. | |
| 2020 | Bugno-Poniewierska, M., Kij, B., Witarski, W., Wojtaszek, M., Radko, A., Podbielska, A., Szczerbal, I., Murphy, W.J. : |
| Fertile male tortoiseshell cat with true chimerism 38,XY/38,XY. Reprod Domest Anim 55:1139-1144, 2020. Pubmed reference: 32574385. DOI: 10.1111/rda.13752. | |
| Jaraud, A., Bossé, P., Dufaure de Citres, C., Tiret, L., Gache, V., Abitbol, M. : | |
| Feline chimerism revealed by DNA profiling. Anim Genet 51:631-633, 2020. Pubmed reference: 32452546. DOI: 10.1111/age.12957. | |
| 2018 | Szczerbal, I., Krzeminska, P., Dzimira, S., Tamminen, T.M., Saari, S., Nizanski, W., Gogulski, M., Nowacka-Woszuk, J., Switonski, M. : |
| Disorders of sex development in cats with different complements of sex chromosomes. Reprod Domest Anim 53:1317-1322, 2018. Pubmed reference: 30099782. DOI: 10.1111/rda.13263. | |
| 2017 | De Lorenzi, L., Banco, B., Previderè, C., Bonacina, S., Romagnoli, S., Grieco, V., Parma, P. : |
| Testicular XX (SRY-negative) disorder of sex development in cat. Sex Dev 11:210-216, 2017. Pubmed reference: 28848109. DOI: 10.1159/000479175. | |
| 2015 | Du, X.Y., Yi, S., Huo, X.Y., Wang, C., Liu, D.F., Ren, W.Z., Chen, Z.W. : |
| Selecting representative microsatellite loci for genetic monitoring and analyzing genetic structure of an outbred population of orange tabby cats in China. Genet Mol Res 14:1788-97, 2015. Pubmed reference: 25867323. DOI: 10.4238/2015.March.13.6. | |
| Szczerbal, I., Stachowiak, M., Dzimira, S., Sliwa, K., Switonski, M. : | |
| The first case of 38,XX (SRY-positive) disorder of sex development in a cat. Mol Cytogenet 8:22, 2015. Pubmed reference: 25838845. DOI: 10.1186/s13039-015-0128-5. | |
| 2014 | Pedersen, A.S., Berg, L.C., Almstrup, K., Thomsen, P.D. : |
| A tortoiseshell male cat: chromosome analysis and histologic examination of the testis. Cytogenet Genome Res 142:107-11, 2014. Pubmed reference: 24335095. DOI: 10.1159/000356466. | |
| 2009 | Schmidt-Küntzel, A., Nelson, G., David, V.A., Schäffer, A.A., Eizirik, E., Roelke, M.E., Kehler, J.S., Hannah, S.S., O'Brien, S.J., Menotti-Raymond, M. : |
| A domestic cat X chromosome linkage map and the sex-linked orange locus: mapping of orange, multiple origins and epistasis over nonagouti. Genetics 181:1415-25, 2009. Pubmed reference: 19189955. DOI: 10.1534/genetics.108.095240. | |
| 2007 | Golubeva, N.A., Zhigachev, A.I. : |
| [New data on coat color gene frequencies in cats: 1. the Armavir population]. Genetika 43:1079-83, 2007. Pubmed reference: 17958308. | |
| 2005 | Grahn, RA., Lemesch, BM., Millon, LV., Matise, T., Rogers, QR., Morris, JG., Fretwell, N., Bailey, SJ., Batt, RM., Lyons, LA. : |
| Localizing the X-linked orange colour phenotype using feline resource families. Anim Genet 36:67-70, 2005. Pubmed reference: 15670134. DOI: 10.1111/j.1365-2052.2005.01239.x. | |
| 2003 | Kuiper, H., Hewicker-Trautwein, M., Distl, O. : |
| [Cytogenetic and histologic examination of four tortoiseshell cats] Dtsch Tierarztl Wochenschr 110:457-61, 2003. Pubmed reference: 14679839. | |
| 2001 | Kosowska, B., Januszewski, A., Tokarska, M., Jach, H., Zdrojewicz, Z. : |
| Cytogenetic and histologic studies of tortoiseshell cats Medycyna Weterynaryjna 57:475-479, 2001. | |
| 2000 | Christensen, A.C. : |
| Cats as an aid to teaching genetics. Genetics 155:999-1004, 2000. Pubmed reference: 10880464. | |
| 1999 | Leaman, T., Rowland, R., Long, S.E. : |
| Male tortoiseshell cats in the United Kingdom Veterinary Record 144:9-12, 1999. Pubmed reference: 10028567. | |
| Long, S.E. : | |
| 38,XX/38,XY chromosome chimaerism in three feline siblings. Vet Rec 145:404-5, 1999. Pubmed reference: 10574275. | |
| 1996 | Axner, E., Strom, B., Linde Forsberg, C., Gustavsson, I., Lindblad, K., Wallgren, M. : |
| Reproductive disorders in 10 domestic male cats Journal of Small Animal Practice 37:394-401, 1996. Pubmed reference: 8872943. | |
| 1995 | Pontier, D., Rioux, N., Heizmann, A. : |
| Evidence of selection on the orange allele in the domestic cat felis catus - the role of social structure Oikos 73:299-308, 1995. | |
| 1992 | Quackenbush, R.E. : |
| Genetics of the Domestic Cat - A Lab Exercise American Biology Teacher 54:29-32, 1992. | |
| 1988 | Chastain, C.B., Guilford, W.G., Schmidt, D. : |
| The 38,XX/39,XXY genotype in cats Compendium on Continuing Education for the Practicing Veterinarian 10:18-22, 1988. | |
| 1987 | Robinson, R. : |
| Mutant gene frequencies in cats of the greater London area. Theor Appl Genet 74:579-83, 1987. Pubmed reference: 24240212. DOI: 10.1007/BF00288855. | |
| Wagner, A., Wolsan, M. : | |
| Pelage mutant allele frequencies in domestic cat populations of Poland. J Hered 78:197-200, 1987. Pubmed reference: 3611716. | |
| 1986 | Miller, W.J., Hollander, W.F. : |
| The sex-linked black cat fallacy: a textbook case Journal of Heredity 77:463-464, 1986. Pubmed reference: 3559170. | |
| 1985 | Robinson, R. : |
| Fertile male tortoise-shell cats Journal of Heredity 76:137-138, 1985. | |
| 1984 | Moran, C., Gillies, C.B., Nicholas, F.W. : |
| Fertile male tortoiseshell cats: mosaicism due to gene instability? Journal of Heredity 75:397-402, 1984. Pubmed reference: 6481130. | |
| 1981 | Hageltorn, M., Gustavsson, I. : |
| XXY-trisomy identified by banding techniques in a male tortoiseshell cat. J Hered 72:132-4, 1981. Pubmed reference: 7196925. | |
| Long, S.E., Gruffydd-Jones, T., David, M. : | |
| Male tortoiseshell cats: an examination of testicular histology and chromosome complement Research in Veterinary Science 30:274-280, 1981. Pubmed reference: 7255921. | |
| 1980 | Nicholas, F.W., Muir, P., Toll, G.L. : |
| An XXY male Burmese cat Journal of Heredity 71:52-54, 1980. | |
| 1979 | Fagan, E.A. : |
| The gingham dog and the calico cat. Nurs Adm Q 3:57-62, 1979. Pubmed reference: 257210. | |
| Logue, DN. : | |
| Tortoiseshell tom. Vet Rec 105:381-2, 1979. Pubmed reference: 532047. | |
| 1975 | Centerwall, WR., Benirschke, K. : |
| An animal model for the XXY Klinefelter's syndrome in man: tortoiseshell and calico male cats. Am J Vet Res 36:1275-80, 1975. Pubmed reference: 1163864. | |
| 1973 | Centerwall, WR., Benirschke, K. : |
| Male tortoiseshell and calico (T-C) cats. Animal models of sex chromosome mosaics, aneuploids, polyploids, and chimerics. J Hered 64:272-8, 1973. Pubmed reference: 4798734. | |
| Lamoreux, ML. : | |
| Brown-orange tortoiseshell cat. J Hered 64:240, 1973. Pubmed reference: 4766215. | |
| 1972 | Robinson, R. : |
| Mutant gene frequencies in cats of Cyprus. Theor Appl Genet 42:293-6, 1972. Pubmed reference: 24431063. DOI: 10.1007/BF00277721. | |
| 1971 | Gregson, NM., Ishmael, J. : |
| Diploid-triploid chimerism in 3 tortoiseshell cats. Res Vet Sci 12:275-9, 1971. Pubmed reference: 5103434. | |
| Pyle, R.L., Patterson, D.F., Hare, W.C., Kelly, D.F., Digiulio, T. : | |
| XXY sex chromosome constitution in a Himalayan cat with tortoise-shell points. J Hered 62:220-2, 1971. Pubmed reference: 5137354. | |
| 1970 | Loughman, W.D., Frye, F.L., Condon, T.B. : |
| XY/XXY bone marrow mosaicism in three tricolour cats American Journal of Veterinary Research 31:307-314, 1970. Pubmed reference: 5414872. | |
| 1969 | Robinson, R., Silson, M. : |
| Mutant gene frequencies in cats of Southern England. Theor Appl Genet 39:326-9, 1969. Pubmed reference: 24435560. DOI: 10.1007/BF00281914. | |
| 1967 | Malouf, N.K., Benirschke, K., Hoefnagel, D. : |
| XX/XY chimerism in a tricoloured male cat Cytogenetics 6:228-241, 1967. Pubmed reference: 6035565. | |
| 1964 | Chu, EH., Thuline, HC., Norby, DE. : |
| Triploid-diploid chimerism in a male tortoiseshell cat Cytogenetics 24:1-18, 1964. Pubmed reference: 14154339. | |
| Thuline, H.C. : | |
| Male tortoiseshell, chimerism and true hermaphroditism Journal of Cat Genetics 4:2-3, 1964. | |
| 1961 | Thuline, H.C., Norby, D.E. : |
| Spontaneous occurrence of chromosome abnormality in cats Science 134:554-555, 1961. Pubmed reference: 13776765. | |
| 1957 | Jude, AC., Searle, AG. : |
| A fertile tortoiseshell tomcat. Nature 179:1087-8, 1957. Pubmed reference: 13430803. | |
| Little, CC : | |
| The yellow Siamese cat Journal of Heredity 48:57-58, 1957. | |
| 1956 | Ishihara, T. : |
| Cytological studies on tortoiseshell male cats Cytologia 21:391-398, 1956. | |
| Sprague, L.M., Stormont, C. : | |
| A reanalysis of the problem of the male Tortoiseshell cat Journal of Heredity 47:237-240, 1956. | |
| 1927 | Bamber, R.C., Herdman, E.C. : |
| The inheritance of black, yellow and tortoiseshell coat colour in cats Journal of Genetics 18:87-97, 1927. | |
| 1919 | Little, C.C. : |
| Colour inheritance in cats, with special reference to colours, black, yellow and tortoiseshell. Journal of Genetics 8:279–290, 1919. DOI: 10.1007/BF02983269. | |
| 1918 | Wright, S. : |
| Color inheritance in mammals. X. The cat - Curious association of deafness with blue-eyed white color and femaleness with tortoise-shelled color, long known - variations of tiger pattern present in interesting features Journal of Heredity 9:139-144, 1918. DOI: 10.1093/oxfordjournals.jhered.a111923. | |
| 1916 | Ibsen, H.L. : |
| Tricolor Inheritance. III. Tortoiseshell Cats. Genetics 1:377-86, 1916. Pubmed reference: 17245865. DOI: 10.1093/genetics/1.4.377. | |
| 1913 | Domcaster, L. : |
| On sex-limited inheritance in cats, and its bearing on the sex-limited transmission of certain human abnormalities. Journal of Genetics 3:11-23, 1913. DOI: 10.1007/BF02981561. | |
| 1909 | Bateson, W. : |
| Mendel’s Principles of Heredity. Cambridge University Press, London , 1909. URL: https://www.biodiversitylibrary.org/item/15713#page/9/mode/1up. | |
| 1904 | Doncaster, L. : |
| On the inheritance of tortoiseshell and related colours in cats Proceedings of the Cambridge Philosophical Society 13:35-38, 1904. |
Edit History
- Created by Frank Nicholas on 17 Sep 2005
- Changed by Frank Nicholas on 07 Jun 2012
- Changed by Imke Tammen2 on 15 Jun 2023
- Changed by Imke Tammen2 on 19 Aug 2023