OMIA:000654-9615 : Myxomatous valvular degeneration in Canis lupus familiaris (dog) |
In other species: African ostrich , golden eagle , Rose-ringed parakeet , blue-fronted amazon , bald eagle , jackass penguin
Categories: Cardiovascular system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 157700 (trait) , 607829 (trait) , 610840 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: yes
Key variant known: no
Cross-species summary: Renamed from 'Mitral valve disease' [28/06/2023]. Disease due to mitral valve (also called bicuspid valve or left atrioventricular valve) or tricuspid valve (also called right atrioventricular valve) or aortic valve degeneration. More than one valve may be may be involved in individual patients. The pathophysiology is unclear, but genetic predispositions have been reported in some species.
Species-specific name: Myxomatous mitral valve disease
Species-specific symbol: MMVD
Mapping: By conducting a GWAS on 139 affected and 102 normal Cavalier King Charles Spaniels, each genotyped with the Canine HD Bead Chip (yielding 84,693 SNPs for analysis), Madsen et al. (2011) "identified a 1.58 Mb region on CFA13 (P(genome) = 4.0× 10(-5)) and a 1.68 Mb region on CFA14 (P(genome) = 7.9× 10(-4)) associated with development of MMVD". By conducting a GWAS on 36 Cavalier King Charles Spaniel, each genotyped with the Illumina HD SNP chip (yielding more than 170,000 SNPs for analysis), French et al. (2012) were not able to identify any chromosomal regions of interest. Williams et al. (2021) "evaluated DNA from 50 affected dogs from five different dog breeds in a whole genome sequencing approach to identify shared variants across and within breeds that could be associated with MMVD. .... Only one of these could be associated with the cardiac valve (Chr12:36801705, COL12A1; CKCS [Cavalier King Charles Spaniel]) but when evaluated in an additional 100 affected CKCS the variant was only identified in 84/100 affected dogs, perhaps indicating genetic heterogeneity in this disease." Axelsson et al. (2021) "analysed eight dog breeds and identified an increased mutational load in the cKCs breed [Cavalier King Charles Spaniels], which is highly bottlenecked. This breed has a high frequency of MMVD. Looking for derived alleles of high frequency specifically in this breed, we identified four highly conserved variants in protein coding genes that may relate to MMVD as well as several candidate regulatory variants near the NEBL gene. We find that some of these NEBL variants are associated with MMVD in dachshund and may be affecting gene expression in multiple relevant heart cell types and thus probably affect heart function. These results merit further validation in separate cohorts." Mead et al. (2022): "Previous research has suggested that selected candidate risk alleles for MMVD are fixed in CKCSs [Cavalier King Charles Spaniels], including six locations within the Nebulette (NEBL) gene on CFA2. The current study analysed genotypes of 180 Australian CKCSs at the identified risk loci. Of these, 178 were phenotyped for severity of disease by echocardiographic measurements of left atrium to aortic root ratio (LA:Ao) and weight normalised left ventricular end diastolic diameter (LVIDdN). Genotyping array markers correctly predicted the genotype at the risk-variant loci in the CKCS population, and the NEBL1, NEBL2 and NEBL3 variants were observed to be in perfect linkage disequilibrium in this cohort. The CKCS cohort included 6/178 dogs being heterozygous for the protective/wild-type alleles at the NEBL locus. The mean LA:Ao and LVIDdN scores of these dogs heterozygous at NEBL1-3 variants were significantly smaller, and with significantly lower variance compared to age-matched CKCSs that were homozygous for risk alleles. The lower cardiac measurements in the heterozygous dogs indicate a significantly reduced risk of severe MMVD disease. Our analysis suggests that despite relative fixation of the NEBL risk alleles, healthy reference alleles at NEBL1-3 exist in low frequency in the CKCS breed and can be used to reduce MMVD severity and mortality."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breeds:
Borzoi (Dog) (VBO_0200197),
Cavalier King Charles Spaniel (Dog) (VBO_0200309),
Dachshund (Dog) (VBO_0200406),
Miniature Schnauzer (Dog) (VBO_0200896),
Poodle, Miniature (Dog) (VBO_0201051),
Yorkshire Terrier (Dog) (VBO_0201448).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000654-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Bach, M.B.T., Stougaard, C.L., Thøfner, M.S., Reimann, M.J., Westrup, U., Koch, J., Fredholm, M., Martinussen, T., Berendt, M., Olsen, L.H. : |
| Relationship between syringomyelia and myxomatous mitral valve disease in Cavalier King Charles spaniels. J Vet Intern Med , 2024. Pubmed reference: 38391152. DOI: 10.1111/jvim.17018. | |
| Chetboul, V., Poissonnier, C., Foulex, P., Alvarado, M.P., Trehiou-Sechi, É., Saponaro, V., Passavin, P., Desquilbet, L. : | |
| Volumetric quantification identifies some left atrial dilations undetected by left atrium:aorta ratio measurements: A prospective echocardiographic study in 155 Cavalier King Charles Spaniels with and without degenerative mitral valve disease. PLoS One 19:e0300827, 2024. Pubmed reference: 38547236. DOI: 10.1371/journal.pone.0300827. | |
| Crosara, S., Fidanzio, F., Oricco, S., Dondi, F., Mazzoldi, C., Monari, E., Romito, G., Sabetti, M.C., Troìa, R., Quintavalla, C. : | |
| Association between echocardiographic indexes and urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in dogs with myxomatous mitral valve disease. Res Vet Sci 171:S0034-5288(24)00077-8:105211, 2024. Pubmed reference: 38458044. DOI: 10.1016/j.rvsc.2024.105211. | |
| Mihara, K., Kanemoto, I., Sato, K., Yasuhira, Y., Watanabe, I., Suzuki, Y., Nagura, J., Misumi, K. : | |
| Effects of mitral valve repair on valvular geometry and hemodynamics in dogs with myxomatous mitral valve disease. Vet Surg 53:415-425, 2024. Pubmed reference: 38205863. DOI: 10.1111/vsu.14068. | |
| Sakarin, S., Rungsipipat, A., Roytrakul, S., Jaresitthikunchai, J., Phaonakrop, N., Charoenlappanit, S., Thaisakun, S., Surachetpong, S.D. : | |
| Proteomic analysis of pulmonary arteries and lung tissues from dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease. PLoS One 19:e0296068, 2024. Pubmed reference: 38181036. DOI: 10.1371/journal.pone.0296068. | |
| Sakarin, S., Rungsipipat, A., Roytrakul, S., Jaresitthikunchai, J., Phaonakrop, N., Charoenlappanit, S., Thaisakun, S., Surachetpong, S.D. : | |
| Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study. Front Vet Sci 11:1327453, 2024. Pubmed reference: 38596466. DOI: 10.3389/fvets.2024.1327453. | |
| Svensson, M., Selling, J., Dirven, M. : | |
| Myxomatous mitral valve disease in large breed dogs: Survival characteristics and prognostic variables. Vet Sci 11:136, 2024. Pubmed reference: 38535870. DOI: 10.3390/vetsci11030136. | |
| van Staveren, M.D.B., Muis, E., Szatmári, V. : | |
| Self-reported utilization of international (ACVIM Consensus) guidelines and the latest clinical trial results on the treatment of dogs with various stages of myxomatous mitral valve degeneration: A survey among veterinary practitioners. Animals (Basel) 14:772, 2024. Pubmed reference: 38473157. DOI: 10.3390/ani14050772. | |
| Wesselowski, S., Sykes, K.T., Saunders, A.B., Werre, S.R. : | |
| Echocardiographic values and prevalence of cardiac abnormalities in clinically healthy adult Borzoi dogs. Am J Vet Res :1-10, 2024. Pubmed reference: 38154250. DOI: 10.2460/ajvr.23.11.0255. | |
| Yang, V.K., Moyer, N., Zhou, R., Carnevale, S.Z., Meola, D.M., Robinson, S.R., Li, G., Das, S. : | |
| Defining the role of the miR-145-KLF4-αSMA axis in mitral valvular interstitial cell activation in myxomatous mitral valve prolapse using the canine model. Int J Mol Sci 25:1468, 2024. Pubmed reference: 38338749. DOI: 10.3390/ijms25031468. | |
| Yu, H., Lee, D., Chae, Y., Choi, M., Lee, Y., Yun, T., Kang, B.T., Yang, M.P., Kim, H. : | |
| Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs. Am J Vet Res :1-9, 2024. Pubmed reference: 38531156. DOI: 10.2460/ajvr.23.12.0289. | |
| 2023 | Adler, E., Tidholm, A. : |
| Prevalence of mitral valve regurgitation in 102 asymptomatic Chinese Crested dogs. J Vet Cardiol 46:55-61, 2023. Pubmed reference: 37058906. DOI: 10.1016/j.jvc.2022.09.006. | |
| Aherne, M. : | |
| Cardiac disease and screening in breeding dogs. Vet Clin North Am Small Anim Pract , 2023. Pubmed reference: 37353418. DOI: 10.1016/j.cvsm.2023.05.001. | |
| Baisan, R.A., Vulpe, V. : | |
| Determination of radiographic vertebral heart score and vertebral left atrial size cutoffs based on echocardiographic left atrial size in dogs with myxomatous mitral valve disease. Vet Radiol Ultrasound , 2023. Pubmed reference: 38148480. DOI: 10.1111/vru.13324. | |
| Brložnik, M., Pečjak, A., Nemec Svete, A., Domanjko Petrič, A. : | |
| Selected hematological, biochemical, and echocardiographic variables as predictors of survival in canine patients with myxomatous mitral valve disease and congestive heart failure. J Vet Cardiol 46:18-29, 2023. Pubmed reference: 37023673. DOI: 10.1016/j.jvc.2023.03.001. | |
| Chalermpromma, P., Surachetpong, S.D. : | |
| Indicators for pulmonary hypertension in dogs with degenerative mitral valve disease. Vet World 16:2515-2520, 2023. Pubmed reference: 38328363. DOI: 10.14202/vetworld.2023.2515-2520. | |
| Chirathanaphirom, S., Chuammitri, P., Pongkan, W., Manachai, N., Chantawong, P., Boonsri, B., Boonyapakorn, C. : | |
| Differences in Levels of Mitochondrial DNA Content at Various Stages of Canine Myxomatous Mitral Valve Disease. Animals (Basel) 13:3850, 2023. Pubmed reference: 38136887. DOI: 10.3390/ani13243850. | |
| Czech, A.A., Glaus, T.M., Testa, F., Romito, G., Baron Toaldo, M. : | |
| Clinical presentation, echocardiographic findings, treatment strategies, and prognosis of dogs with myxomatous mitral valve disease presented with pericardial effusion due to suspected left atrial tear: a retrospective case-control study. J Vet Cardiol 51:S1760-2734(23)00087-5:105-115, 2023. Pubmed reference: 38128416. DOI: 10.1016/j.jvc.2023.11.005. | |
| DeProspero, D.J., Hess, R.S., Silverstein, D.C. : | |
| Neutrophil-to-lymphocyte ratio is increased in dogs with acute congestive heart failure secondary to myxomatous mitral valve disease compared to both dogs with heart murmurs and healthy controls. J Am Vet Med Assoc :1-8, 2023. Pubmed reference: 37406992. DOI: 10.2460/javma.23.03.0131. | |
| Freeman, L.M., Rush, J.E., Karlin, E.T. : | |
| Untargeted metabolomic profiling of dogs with myxomatous mitral valve disease and congestive heart failure shows metabolic differences associated with the presence of cardiac cachexia. Am J Vet Res 84:ajvr.23.07.0161, 2023. Pubmed reference: 38041949. DOI: 10.2460/ajvr.23.07.0161. | |
| Hammond, H.H., Ames, M.K., Domenig, O., Scansen, B.A., Yang, N.T., Wilson, M.D., Sunshine, E., Brunk, K., Masters, A. : | |
| The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease. J Vet Intern Med , 2023. Pubmed reference: 36951394. DOI: 10.1111/jvim.16687. | |
| Iwasa, N., Kumazawa, R., Nomura, S., Shimizu, M., Iwata, M., Hara, M., Kawabe, M., Kobatake, Y., Takashima, S., Nishii, N. : | |
| Prognostic value of serum cystatin C concentration in dogs with myxomatous mitral valve disease. J Vet Intern Med , 2023. Pubmed reference: 36852471. DOI: 10.1111/jvim.16669. | |
| Jang, I.S., Yoon, W.K., Choi, E.W. : | |
| N-terminal pro-B-type natriuretic peptide levels in normotensive and hypertensive dogs with myxomatous mitral valve disease stage B. Ir Vet J 76:3, 2023. Pubmed reference: 36755290. DOI: 10.1186/s13620-023-00233-0. | |
| Kim, H.J., Kim, J., Kim, S., Kim, H.J. : | |
| Can cartilage intermediate layer protein 1 (CILP1) use as a novel biomarker for canine myxomatous mitral valve degeneration levels or not? BMC Vet Res 19:59, 2023. Pubmed reference: 36882760. DOI: 10.1186/s12917-023-03583-7. | |
| Kim, O.K., Kim, K., Park, S., Yang, H., Kim, H., Ro, W.B., Lee, C.M. : | |
| Clinical relevance of serum ionized magnesium concentration in dogs with myxomatous mitral valve disease. J Vet Intern Med , 2023. Pubmed reference: 38064361. DOI: 10.1111/jvim.16963. | |
| Kim, Y., Kim, J., Kim, S., Youn, H., Choi, J., Seo, K. : | |
| Machine learning-based risk prediction model for canine myxomatous mitral valve disease using electronic health record data. Front Vet Sci 10:1189157, 2023. Pubmed reference: 37720471. DOI: 10.3389/fvets.2023.1189157. | |
| Kim, Y.M., Kim, S.W., Kim, J.H. : | |
| Galectin-3 is able to differentiate dogs with myxomatous mitral valve disease from healthy control dogs. Am J Vet Res :1-8, 2023. Pubmed reference: 37567572. DOI: 10.2460/ajvr.23.03.0063. | |
| Koster, L., Vogel, J., Springer, C.M., Hecht, S. : | |
| Radiographic lung congestion scores in dogs with acute congestive heart failure caused by myxomatous mitral valve disease. J Vet Intern Med , 2023. Pubmed reference: 37694988. DOI: 10.1111/jvim.16850. | |
| Ku, D., Chae, Y., Kim, C., Koo, Y., Lee, D., Yun, T., Chang, D., Kang, B.T., Yang, M.P., Kim, H. : | |
| Severity of myxomatous mitral valve disease in dogs may be predicted using neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratio. Am J Vet Res :1-9, 2023. Pubmed reference: 37024099. DOI: 10.2460/ajvr.23.01.0012. | |
| Lee, H.J., Park, H.J., Song, J.H., Song, K.H. : | |
| Correlation between the leaflet-annulus index and echocardiographic indices in Maltese dogs with myxomatous mitral valve disease. Vet Sci 10, 2023. Pubmed reference: 37624280. DOI: 10.3390/vetsci10080493. | |
| Mazzarella, M.O., Jones, N.K., Culshaw, G.J. : | |
| Isometric myography is a feasible method to identify and quantify endothelial dysfunction in dogs with myxomatous mitral valve disease. Am J Vet Res :1-7, 2023. Pubmed reference: 37709264. DOI: 10.2460/ajvr.23.06.0136. | |
| McNair, A.J., Markby, G.R., Tang, Q., MacRae, V.E., Corcoran, B.M. : | |
| TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease. Front Vet Sci 10:1202001, 2023. Pubmed reference: 37908840. DOI: 10.3389/fvets.2023.1202001. | |
| Morita, T., Nakamura, K., Osuga, T., Kawamoto, S., Takiguchi, M. : | |
| Interventricular inflow time difference assessed by dual pulsed-wave Doppler echocardiography in dogs with myxomatous mitral valve disease. J Vet Cardiol 51:S1760-2734(23)00100-5:24-34, 2023. Pubmed reference: 38071798. DOI: 10.1016/j.jvc.2023.11.011. | |
| Pereira, N. : | |
| Mitral annular disjunction and myxomatous mitral valve disease in a dog. J Vet Cardiol 51:9-12, 2023. Pubmed reference: 37989026. DOI: 10.1016/j.jvc.2023.10.003. | |
| Reimann, M.J., Cremer, S., Christiansen, L., Ibragimov, E., Gao, F., Cirera, S., Fredholm, M., Olsen, L.H., Karlskov-Mortensen, P. : | |
| Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease. Mamm Genome , 2023. Pubmed reference: 37938355. DOI: 10.1007/s00335-023-10024-1. | |
| Rešetar Maslov, D., Farkaš, V., Rubić, I., Kuleš, J., Beletić, A., Beer Ljubić, B., Šmit, I., Mrljak, V., Torti, M. : | |
| Serum proteomic profiles reflect the stages of myxomatous mitral valve disease in dogs. Int J Mol Sci 24:7142, 2023. Pubmed reference: 37108311. DOI: 10.3390/ijms24087142. | |
| Sakarin, S., Rungsipipat, A., Surachetpong, S.D. : | |
| Perivascular inflammatory cells and their association with pulmonary arterial remodelling in dogs with pulmonary hypertension due to myxomatous mitral valve disease. Vet Res Commun , 2023. Pubmed reference: 36976445. DOI: 10.1007/s11259-023-10106-0. | |
| Sykes, K.T., Wesselowski, S., Saunders, A.B., Tjostheim, S.S., Potter, B.M., Gelzer, A.R.M., Katz, N., Ward, J.L., Karlin, E.T., Markovic, L.E., Magee, A.N., Abbott, J.A., Kadotani, S., Menciotti, G. : | |
| A multicenter, retrospective study of cardiac disease in Borzoi dogs. Front Vet Sci 10:1102494, 2023. Pubmed reference: 36777677. DOI: 10.3389/fvets.2023.1102494. | |
| Takahashi, A., Takeuchi, S., Chen, A., Uechi, M. : | |
| A survey on dogs with valvular disease flying to Japan for operation. Sci Rep 13:4675, 2023. Pubmed reference: 36973265. DOI: 10.1038/s41598-023-29476-1. | |
| Tang, Q., Markby, G.R., MacNair, A.J., Tang, K., Tkacz, M., Parys, M., Phadwal, K., MacRae, V.E., Corcoran, B.M. : | |
| TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease. Cell Prolif :e13435, 2023. Pubmed reference: 36869852. DOI: 10.1111/cpr.13435. | |
| Tangmahakul, N., Orton, E.C., Surachetpong, S.D. : | |
| Investigation of red blood cell and platelet indices in adult dogs suffered from myxomatous mitral valve disease with and without pulmonary hypertension. Front Vet Sci 10:1234768, 2023. Pubmed reference: 37781288. DOI: 10.3389/fvets.2023.1234768. | |
| Tomsič, K., Domanjko Petrič, A., Nemec, A., Pirman, T., Rezar, V., Seliškar, A., Vovk, T., Nemec Svete, A. : | |
| Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1. Front Vet Sci 10:1203480, 2023. Pubmed reference: 37745214. DOI: 10.3389/fvets.2023.1203480. | |
| Valente, C., Wodzinski, M., Guglielmini, C., Poser, H., Chiavegato, D., Zotti, A., Venturini, R., Banzato, T. : | |
| Development of an artificial intelligence-based method for the diagnosis of the severity of myxomatous mitral valve disease from canine chest radiographs. Front Vet Sci 10:1227009, 2023. Pubmed reference: 37808107. DOI: 10.3389/fvets.2023.1227009. | |
| van Staveren, M.D.B., Muis, E., Szatmári, V. : | |
| Self-reported utilization of international guidelines for staging dogs with myxomatous mitral valve degeneration: A survey among veterinary practitioners. Vet Sci 10:687, 2023. Pubmed reference: 38133238. DOI: 10.3390/vetsci10120687. | |
| Vereb, M., Atkins, C.E., Adin, D., Blondel, T., Coffman, M., Lee, S., Guillot, E., Ward, J.L. : | |
| Efficacy of a mitral regurgitation severity index to predict long-term outcome in dogs with myxomatous mitral valve disease. J Vet Intern Med , 2023. Pubmed reference: 37909399. DOI: 10.1111/jvim.16923. | |
| Wesselowski, S. : | |
| Resolution of congestive heart failure and reverse remodeling in two Chihuahuas with flail mitral valve leaflets. J Vet Cardiol 47:55-63, 2023. Pubmed reference: 37245348. DOI: 10.1016/j.jvc.2023.05.002. | |
| Wesselowski, S., Gordon, S.G., Fries, R., Saunders, A.B., Sykes, K.T., Vitt, J., Boutet, B., Häggström, J., Kadotani, S., Stack, J., Barnett, B.G. : | |
| Use of physical examination, electrocardiography, radiography, and biomarkers to predict echocardiographic stage B2 myxomatous mitral valve disease in preclinical Cavalier King Charles Spaniels. J Vet Cardiol 50:1-16, 2023. Pubmed reference: 37913604. DOI: 10.1016/j.jvc.2023.10.001. | |
| Yuchi, Y., Suzuki, R., Yasumura, Y., Saito, T., Teshima, T., Matsumoto, H., Koyama, H. : | |
| Prognostic value of pulmonary vascular resistance estimated by echocardiography in dogs with myxomatous mitral valve disease and pulmonary hypertension. J Vet Intern Med , 2023. Pubmed reference: 36994902. DOI: 10.1111/jvim.16686. | |
| Yun, H., Koo, Y., Yun, T., Chae, Y., Lee, D., Cha, S., Kim, J., Kim, H., Yang, M.P., Kang, B.T. : | |
| Evaluation of progression of chronic kidney disease in dogs with myxomatous mitral valve disease. Front Vet Sci 10:1200653, 2023. Pubmed reference: 37691634. DOI: 10.3389/fvets.2023.1200653. | |
| Zhou, Q., Wu, Z., Li, L., Zhou, H., Chen, Y., Guo, S., Guo, Y., Ma, X., Zhang, J., Feng, W., Cui, X., Qiu, C., Xu, M., Deng, G. : | |
| Proteomics reveals plasma protein SERPINH1 as a potential diagnostic biomarkers for myxomatous mitral valve disease stage B2. J Proteomics 282:104924, 2023. Pubmed reference: 37146676. DOI: 10.1016/j.jprot.2023.104924. | |
| Zhou, Q., Cui, X., Zhou, H., Guo, S., Wu, Z., Li, L., Zhang, J., Feng, W., Guo, Y., Ma, X., Chen, Y., Qiu, C., Xu, M., Deng, G. : | |
| Differentially expressed platelet activation-related genes in dogs with stage B2 myxomatous mitral valve disease. BMC Vet Res 19:271, 2023. Pubmed reference: 38087280. DOI: 10.1186/s12917-023-03789-9. | |
| 2022 | Axelsson, E., Ljungvall, I., Bhoumik, P., Conn, L.B., Muren, E., Ohlsson, Å., Olsen, L.H., Engdahl, K., Hagman, R., Hanson, J., Kryvokhyzha, D., Pettersson, M., Grenet, O., Moggs, J., Rio-Espinola, A.D., Epe, C., Taillon, B., Tawari, N., Mane, S., Hawkins, T., Hedhammar, Å., Gruet, P., Häggström, J., Lindblad-Toh, K. : |
| Correction: The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels. PLoS Genet 18:e1010039, 2022. Pubmed reference: 35085237. DOI: 10.1371/journal.pgen.1010039. | |
| Bagardi, M., Palermo, V., Locatelli, C., Colombo, F.M., Pazzagli, L., Brambilla, P.G. : | |
| Database development and survival analysis in a clinical and historical cohort of dogs affected by myxomatous mitral valve disease treated or not with pimobendan using causal inference techniques. Vet Res Commun , 2022. Pubmed reference: 35034282. DOI: 10.1007/s11259-021-09875-3. | |
| Bagardi, M., Zamboni, V., Locatelli, C., Galizzi, A., Ghilardi, S., Brambilla, P.G. : | |
| Management of chronic congestive heart failure caused by myxomatous mitral valve disease in dogs: A narrative review from 1970 to 2020. Animals (Basel) 12:209, 2022. Pubmed reference: 35049831. DOI: 10.3390/ani12020209. | |
| Chompoosan, C., Schrøder, A.S., Höllmer, M., Bach, M.B.T., Møgelvang, R., Willesen, J.L., Langhorn, R., Koch, J. : | |
| Epidemiology of heart disease in English Bull Terriers and echocardiographic characteristics of mitral valve abnormalities. J Small Anim Pract , 2022. Pubmed reference: 35014064. DOI: 10.1111/jsap.13472. | |
| Lawrence-Mills, S.J., Hezzell, M.J., Adamantos, S.E., Chan, I., Borgeat, K., Rose Payne, J., Satchell, S., Welsh, G.I., Foster, R.R., Finch, N. : | |
| Circulating hyaluronan as a marker of endothelial glycocalyx damage in dogs with myxomatous mitral valve disease and dogs in a hypercoagulable state. Vet J 285:105845, 2022. Pubmed reference: 35640794. DOI: 10.1016/j.tvjl.2022.105845. | |
| Mead, S.E., Beijerink, N.J., O'Brien, M., Wade, C.M. : | |
| Genetic variants at the Nebulette locus are associated with myxomatous mitral valve disease severity in Cavalier King Charles Spaniels. Genes (Basel) 13:2292, 2022. Pubmed reference: 36553559. DOI: 10.3390/genes13122292. | |
| Tang, Q., McNair, A.J., Phadwal, K., Macrae, V.E., Corcoran, B.M. : | |
| The role of transforming growth factor-β signaling in myxomatous mitral valve degeneration. Front Cardiovasc Med 9:872288, 2022. Pubmed reference: 35656405. DOI: 10.3389/fcvm.2022.872288. | |
| 2021 | Axelsson, E., Ljungvall, I., Bhoumik, P., Conn, L.B., Muren, E., Ohlsson, Å., Olsen, L.H., Engdahl, K., Hagman, R., Hanson, J., Kryvokhyzha, D., Pettersson, M., Grenet, O., Moggs, J., Del Rio-Espinola, A., Epe, C., Taillon, B., Tawari, N., Mane, S., Hawkins, T., Hedhammar, Å., Gruet, P., Häggström, J., Lindblad-Toh, K. : |
| The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels. PLoS Genet 17:e1009726, 2021. Pubmed reference: 34473707. DOI: 10.1371/journal.pgen.1009726. | |
| Bagardi, M., Locatelli, C., Manfredi, M., Bassi, J., Spediacci, C., Ghilardi, S., Zani, D.D., Brambilla, P.G. : | |
| Breed-specific vertebral heart score, vertebral left atrial size, and radiographic left atrial dimension in Cavalier King Charles Spaniels: Reference interval study. Vet Radiol Ultrasound , 2021. Pubmed reference: 34796576. DOI: 10.1111/vru.13036. | |
| Baisan, R.A., Turcu, C.A., Condurachi, E.I., Vulpe, V. : | |
| Retrospective evaluation of notched and fragmented QRS complex in dogs with naturally occurring myxomatous mitral valve disease. Vet Q :1-9, 2021. Pubmed reference: 34643161. DOI: 10.1080/01652176.2021.1992803. | |
| Donati, P., Tarducci, A., Zanatta, R., Verdier, N., Belerenian, G., Cordero, I., Villalta, C., Franco, J., Tarragona, L. : | |
| Angiotensin-converting enzyme inhibitors in preclinical myxomatous mitral valve disease in dogs: systematic review and meta-analysis. J Small Anim Pract , 2021. Pubmed reference: 34905219. DOI: 10.1111/jsap.13461. | |
| Dos Santos, J.P., Lucina, S.B., da Costa, B.N., Olaguivel, K.L.C., Tuleski, G.L.R., Sousa, M.G. : | |
| Assessment of heart rate turbulence in dogs with myxomatous mitral valve disease. Open Vet J 11:635-644, 2021. Pubmed reference: 35070858. DOI: 10.5455/OVJ.2021.v11.i4.13. | |
| Mihara, K., Kanemoto, I., Sato, K., Yasuhira, Y., Watanabe, I., Misumi, K. : | |
| Echocardiographic evaluation of deformity and enlargement of the canine mitral valve annulus associated with myxomatous degenerative mitral valve disease. J Vet Cardiol 37:8-17, 2021. Pubmed reference: 34507141. DOI: 10.1016/j.jvc.2021.08.002. | |
| Morita, T., Nakamura, K., Osuga, T., Takiguchi, M. : | |
| Incremental predictive value of echocardiographic indices of right ventricular function in the assessment of long-term prognosis in dogs with myxomatous mitral valve disease. J Vet Cardiol 39:51-62, 2021. Pubmed reference: 34979482. DOI: 10.1016/j.jvc.2021.12.002. | |
| O'Brien, M.J., Beijerink, N.J., Wade, C.M. : | |
| Genetics of canine myxomatous mitral valve disease. Anim Genet 52:409-21, 2021. Pubmed reference: 34028063. DOI: 10.1111/age.13082. | |
| Petchdee, S., Yalong, M., Kaewnet, M., Ithisariyanont, B., Padawong, T. : | |
| Assessment of right ventricular function, blood lactate levels, and serum peptidomics profiles associated with mitral valve disease in dogs. Front Vet Sci 8:789137, 2021. Pubmed reference: 35127880. DOI: 10.3389/fvets.2021.789137. | |
| Reimann, M.J., Fredholm, M., Cremer, S.E., Christiansen, L.B., Meurs, K.M., Møller, J.E., Häggström, J., Lykkesfeldt, J., Olsen, L.H. : | |
| Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease. J Vet Intern Med 35:2596-2606, 2021. Pubmed reference: 34599615. DOI: 10.1111/jvim.16277. | |
| Williams, B., Friedenberg, S.G., Keene, B.W., Tou, S.P., DeFrancesco, T.C., Meurs, K.M. : | |
| Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease. Hum Genet , 2021. Pubmed reference: 34176051. DOI: 10.1007/s00439-021-02297-w. | |
| Wolf, M., Lucina, S.B., Silva, V.B.C., Tuleski, G.L.R., Sarraff, A.P., Komatsu, E.Y., Sousa, M.G. : | |
| Assessment of longitudinal systolic function using tissue motion annular displacement in dogs with degenerative mitral valve disease. J Vet Cardiol 38:44-58, 2021. Pubmed reference: 34800922. DOI: 10.1016/j.jvc.2021.10.004. | |
| 2020 | Bionda, A., Cortellari, M., Bagardi, M., Frattini, S., Negro, A., Locatelli, C., Brambilla, P.G., Crepaldi, P. : |
| A genomic study of myxomatous mitral valve disease in Cavalier King Charles Spaniels. Animals (Basel) 10, 2020. Pubmed reference: 33081147. DOI: 10.3390/ani10101895. | |
| Brambilla, P.G., Polli, M., Pradelli, D., Papa, M., Rizzi, R., Bagardi, M., Bussadori, C. : | |
| Epidemiological study of congenital heart diseases in dogs: Prevalence, popularity, and volatility throughout twenty years of clinical practice. PLoS One 15:e0230160, 2020. Pubmed reference: 32716943. DOI: 10.1371/journal.pone.0230160. | |
| Markby, G.R., Macrae, V.E., Summers, K.M., Corcoran, B.M. : | |
| Disease severity-associated gene expression in canine myxomatous mitral valve disease is dominated by TGFβ signaling. Front Genet 11:372, 2020. Pubmed reference: 32395121. DOI: 10.3389/fgene.2020.00372. | |
| Markby, G.R., Macrae, V.E., Corcoran, B.M., Summers, K.M. : | |
| Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel. BMC Vet Res 16:350, 2020. Pubmed reference: 32967675. DOI: 10.1186/s12917-020-02542-w. | |
| Oyama, M.A., Elliott, C., Loughran, K.A., Kossar, A.P., Castillero, E., Levy, R.J., Ferrari, G. : | |
| Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms. Cardiovasc Pathol 46:107196, 2020. Pubmed reference: 32006823. DOI: 10.1016/j.carpath.2019.107196. | |
| 2019 | Christiansen, L.B., Cremer, S.E., Helander, A., Madsen, T., Reimann, M.J., Møller, J.E., Höglund, K., Ljungvall, I., Häggström, J., Olsen, L.H. : |
| Urine 5-hydroxyindoleacetic acid in Cavalier King Charles spaniels with preclinical myxomatous mitral valve disease. Vet J 250:36-43, 2019. Pubmed reference: 31383418. DOI: 10.1016/j.tvjl.2019.06.005. | |
| Lam, C., Casamian-Sorrosal, D., Monteith, G., Fonfara, S. : | |
| Heart-fatty acid binding protein in dogs with degenerative valvular disease and dilated cardiomyopathy. Vet J 244:16-22, 2019. Pubmed reference: 30825889. DOI: 10.1016/j.tvjl.2018.11.017. | |
| Li, Q., Heaney, A., Langenfeld-McCoy, N., Boler, B.V., Laflamme, D.P. : | |
| Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs. BMC Vet Res 15:425, 2019. Pubmed reference: 31775756. DOI: 10.1186/s12917-019-2169-1. | |
| Meurs, K.M., Adin, D., O'Donnell, K., Keene, B.W., Atkins, C.E., DeFrancesco, T., Tou, S. : | |
| Myxomatous mitral valve disease in the miniature poodle: A retrospective study. Vet J 244:94-97, 2019. Pubmed reference: 30825902. DOI: 10.1016/j.tvjl.2018.12.019. | |
| Sudunagunta, S., Green, D., Christley, R., Dukes-McEwan, J. : | |
| The prevalence of pulmonary hypertension in Cavalier King Charles spaniels compared with other breeds with myxomatous mitral valve disease. J Vet Cardiol 23:21-31, 2019. Pubmed reference: 31174726. DOI: 10.1016/j.jvc.2019.01.002. | |
| 2018 | Carvalho, E.R., Ampuero, R.A.N., Tuleski, G.L.R., Camacho, A.A., Sousa, M.G. : |
| Polymorphism, coupling interval and prematurity index in dogs with degenerative mitral valve disease and ventricular arrhythmias. Vet Res Commun , 2018. Pubmed reference: 29536334. DOI: 10.1007/s11259-018-9718-0. | |
| Meurs, K.M., Friedenberg, S.G., Williams, B., Keene, B.W., Atkins, C.E., Adin, D., Aona, B., DeFrancesco, T., Tou, S., Mackay, T. : | |
| Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration. Vet J 232:16-19, 2018. Pubmed reference: 29428085. DOI: 10.1016/j.tvjl.2017.12.002. | |
| 2017 | Belanger, J.M., Bellumori, T.P., Bannasch, D.L., Famula, T.R., Oberbauer, A.M. : |
| Correlation of neuter status and expression of heritable disorders. Canine Genet Epidemiol 4:6, 2017. Pubmed reference: 28560045. DOI: 10.1186/s40575-017-0044-6. | |
| 2016 | Ahn, S.T., Suh, S.I., Moon, H., Hyun, C. : |
| Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency. Can J Vet Res 80:90-2, 2016. Pubmed reference: 26733738. | |
| Apple, S.M., Menciotti, G., Braz-Ruivo, L., Crosara, S., Häggström, J., Borgarelli, M. : | |
| Effects of pimobendan on myocardial perfusion and pulmonary transit time in dogs with myxomatous mitral valve disease: a pilot study. Aust Vet J 94:324-8, 2016. Pubmed reference: 27569835. DOI: 10.1111/avj.12480. | |
| Boswood, A., Häggström, J., Gordon, S.G., Wess, G., Stepien, R.L., Oyama, M.A., Keene, B.W., Bonagura, J., MacDonald, K.A., Patteson, M., Smith, S., Fox, P.R., Sanderson, K., Woolley, R., Szatmári, V., Menaut, P., Church, W.M., O'Sullivan, M.L., Jaudon, J.P., Kresken, J.G., Rush, J., Barrett, K.A., Rosenthal, S.L., Saunders, A.B., Ljungvall, I., Deinert, M., Bomassi, E., Estrada, A.H., Fernandez Del Palacio, M.J., Moise, N.S., Abbott, J.A., Fujii, Y., Spier, A., Luethy, M.W., Santilli, R.A., Uechi, M., Tidholm, A., Watson, P. : | |
| Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial. J Vet Intern Med , 2016. Pubmed reference: 27678080. DOI: 10.1111/jvim.14586. | |
| Höllmer, M., Willesen, J.L., Tolver, A., Koch, J. : | |
| Left atrial volume and function in dogs with naturally occurring myxomatous mitral valve disease. J Vet Cardiol , 2016. Pubmed reference: 27825670. DOI: 10.1016/j.jvc.2016.08.006. | |
| Janus, I., Noszczyk-Nowak, A., Nowak, M., Ciaputa, R., Kandefer-Gola, M., Pasławska, U. : | |
| A comparison of the histopathologic pattern of the left atrium in canine dilated cardiomyopathy and chronic mitral valve disease. BMC Vet Res 12:3, 2016. Pubmed reference: 26728624. DOI: 10.1186/s12917-015-0626-z. | |
| Kim, H.S., Kang, J.H., Jeung, E.B., Yang, M.P. : | |
| Serum Concentrations of Leptin and Adiponectin in Dogs with Myxomatous Mitral Valve Disease. J Vet Intern Med 30:1589-1600, 2016. Pubmed reference: 27573621. DOI: 10.1111/jvim.14570. | |
| Martinelli, E., Locatelli, C., Bassis, S., Crosara, S., Paltrinieri, S., Scarpa, P., Spalla, I., Zanaboni, A.M., Quintavalla, C., Brambilla, P. : | |
| Preliminary Investigation of Cardiovascular-Renal Disorders in Dogs with Chronic Mitral Valve Disease. J Vet Intern Med 30:1612-1618, 2016. Pubmed reference: 27717188. DOI: 10.1111/jvim.14524. | |
| Mavropoulou, A., Guazzetti, S., Borghetti, P., De Angelis, E., Quintavalla, C. : | |
| Cytokine expression in peripheral blood mononuclear cells of dogs with mitral valve disease. Vet J , 2016. Pubmed reference: 27033593. DOI: 10.1016/j.tvjl.2016.03.002. | |
| Nakamura, K., Morita, T., Osuga, T., Morishita, K., Sasaki, N., Ohta, H., Takiguchi, M. : | |
| Prognostic Value of Right Ventricular Tei Index in Dogs with Myxomatous Mitral Valvular Heart Disease. J Vet Intern Med 30:69-75, 2016. Pubmed reference: 26789419. DOI: 10.1111/jvim.13820. | |
| Sakarin, S., Rungsipipat, A., Surachetpong, S.D. : | |
| Galectin-3 in cardiac muscle and circulation of dogs with degenerative mitral valve disease. J Vet Cardiol 18:34-46, 2016. Pubmed reference: 26786977. DOI: 10.1016/j.jvc.2015.10.007. | |
| Yu, I.B., Huang, H.P. : | |
| Prevalence and Prognosis of Anemia in Dogs with Degenerative Mitral Valve Disease. Biomed Res Int 2016:4727054, 2016. Pubmed reference: 27840827. DOI: 10.1155/2016/4727054. | |
| 2015 | Birkegård, A.C., Reimann, M.J., Martinussen, T., Häggström, J., Pedersen, H.D., Olsen, L.H. : |
| Breeding Restrictions Decrease the Prevalence of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels over an 8- to 10-Year Period. J Vet Intern Med 30:63-8, 2015. Pubmed reference: 26578464. DOI: 10.1111/jvim.13663. | |
| Borgarelli, M., Abbott, J., Braz-Ruivo, L., Chiavegato, D., Crosara, S., Lamb, K., Ljungvall, I., Poggi, M., Santilli, R.A., Haggstrom, J. : | |
| Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. J Vet Intern Med 29:569-74, 2015. Pubmed reference: 25818210. DOI: 10.1111/jvim.12564. | |
| Jung, S.W., Sun, W., Griffiths, L.G., Kittleson, M.D. : | |
| Atrial Fibrillation as a Prognostic Indicator in Medium to Large-Sized Dogs with Myxomatous Mitral Valvular Degeneration and Congestive Heart Failure. J Vet Intern Med 30:51-7, 2015. Pubmed reference: 26681398. DOI: 10.1111/jvim.13800. | |
| Lu, C.C., Liu, M.M., Culshaw, G., Clinton, M., Argyle, D.J., Corcoran, B.M. : | |
| Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: a microarray study. Vet J 204:23-31, 2015. Pubmed reference: 25841900. DOI: 10.1016/j.tvjl.2015.02.021. | |
| Lu, C.C., Liu, M.M., Clinton, M., Culshaw, G., Argyle, D.J., Corcoran, B.M. : | |
| Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease. Vet J 206:377-84, 2015. Pubmed reference: 26586213. DOI: 10.1016/j.tvjl.2015.08.011. | |
| Mattin, M.J., Boswood, A., Church, D.B., McGreevy, P.D., O'Neill, D.G., Thomson, P.C., Brodbelt, D.C. : | |
| Degenerative mitral valve disease: Survival of dogs attending primary-care practice in England. Prev Vet Med 122:436-42, 2015. Pubmed reference: 26058819. DOI: 10.1016/j.prevetmed.2015.05.007. | |
| Reimann, M.J., Ljungvall, I., Hillström, A., Møller, J.E., Hagman, R., Falk, T., Höglund, K., Häggström, J., Olsen, L.H. : | |
| Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. Vet J , 2015. Pubmed reference: 26831162. DOI: 10.1016/j.tvjl.2015.12.006. | |
| Stern, J.A., Hsue, W., Song, K.H., Ontiveros, E.S., Luis Fuentes, V., Stepien, R.L. : | |
| Severity of Mitral Valve Degeneration Is Associated with Chromosome 15 Loci in Whippet Dogs. PLoS One 10:e0141234, 2015. Pubmed reference: 26509595. DOI: 10.1371/journal.pone.0141234. | |
| Tidholm, A., Höglund, K., Häggström, J., Ljungvall, I. : | |
| Diagnostic Value of Selected Echocardiographic Variables to Identify Pulmonary Hypertension in Dogs with Myxomatous Mitral Valve Disease. J Vet Intern Med 29:1510-7, 2015. Pubmed reference: 26365438. DOI: 10.1111/jvim.13609. | |
| 2014 | Reimann, M.J., Møller, J.E., Häggström, J., Markussen, B., Holen, A.E., Falk, T., Olsen, L.H. : |
| R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease. Vet J , 2014. Pubmed reference: 24507881. DOI: 10.1016/j.tvjl.2014.01.001. | |
| 2013 | Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. : |
| Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549. | |
| Bigg, P.W., Baldo, G., Sleeper, M.M., O'Donnell, P.A., Bai, H., Rokkam, V.R., Liu, Y., Wu, S., Giugliani, R., Casal, M.L., Haskins, M.E., Ponder, K.P. : | |
| Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs. Mol Genet Metab 110:319-28, 2013. Pubmed reference: 23856419. DOI: 10.1016/j.ymgme.2013.06.013. | |
| 2012 | Atkins, C.E., Häggström, J. : |
| Pharmacologic management of myxomatous mitral valve disease in dogs. J Vet Cardiol 14:165-84, 2012. Pubmed reference: 22386553. DOI: 10.1016/j.jvc.2012.02.002. | |
| Aupperle, H., Disatian, S. : | |
| Pathology, protein expression and signaling in myxomatous mitral valve degeneration: Comparison of dogs and humans. J Vet Cardiol 14:59-71, 2012. Pubmed reference: 22364722. DOI: 10.1016/j.jvc.2012.01.005. | |
| Borgarelli, M., Buchanan, J.W. : | |
| Historical review, epidemiology and natural history of degenerative mitral valve disease. J Vet Cardiol 14:93-101, 2012. Pubmed reference: 22386588. DOI: 10.1016/j.jvc.2012.01.011. | |
| Chetboul, V., Tissier, R. : | |
| Echocardiographic assessment of canine degenerative mitral valve disease. J Vet Cardiol 14:127-48, 2012. Pubmed reference: 22366573. DOI: 10.1016/j.jvc.2011.11.005. | |
| Fox, P.R. : | |
| Pathology of myxomatous mitral valve disease in the dog J Vet Cardiol 14:103-26, 2012. Pubmed reference: 22386587. DOI: 10.1016/j.jvc.2012.02.001. | |
| French, A.T., Ogden, R., Eland, C., Hemani, G., Pong-Wong, R., Corcoran, B., Summers, K.M. : | |
| Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels. Vet J 193:283-6, 2012. Pubmed reference: 22050842. DOI: 10.1016/j.tvjl.2011.09.011. | |
| Hezzell, M.J., Boswood, A., Chang, Y.M., Moonarmart, W., Souttar, K., Elliott, J. : | |
| The Combined Prognostic Potential of Serum High-Sensitivity Cardiac Troponin I and N-Terminal pro-B-Type Natriuretic Peptide Concentrations in Dogs with Degenerative Mitral Valve Disease. J Vet Intern Med 26:302-11, 2012. Pubmed reference: 22369312. DOI: 10.1111/j.1939-1676.2012.00894.x. | |
| Parker, H.G., Kilroy-Glynn, P. : | |
| Myxomatous mitral valve disease in dogs: Does size matter? J Vet Cardiol 14:19-29, 2012. Pubmed reference: 22356836. DOI: 10.1016/j.jvc.2012.01.006. | |
| Reynolds, C.A., Brown, D.C., Rush, J.E., Fox, P.R., Nguyenba, T.P., Lehmkuhl, L.B., Gordon, S.G., Kellihan, H.B., Stepien, R.L., Lefbom, B.K., Kate Meier, C., Oyama, M.A. : | |
| Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study. J Vet Cardiol 14:193-202, 2012. Pubmed reference: 22366568. DOI: 10.1016/j.jvc.2012.01.008. | |
| 2011 | Borgarelli, M., Crosara, S., Lamb, K., Savarino, P., La Rosa, G., Tarducci, A., Haggstrom, J. : |
| Survival characteristics and prognostic variables of dogs with preclinical chronic degenerative mitral valve disease attributable to myxomatous degeneration. J Vet Intern Med 26:69-75, 2011. Pubmed reference: 22211523. DOI: 10.1111/j.1939-1676.2011.00860.x. | |
| Lewis, T., Swift, S., Woolliams, JA., Blott, S. : | |
| Heritability of premature mitral valve disease in Cavalier King Charles spaniels. Vet J 188:73-76, 2011. Pubmed reference: 20347358. DOI: 10.1016/j.tvjl.2010.02.016. | |
| Madsen, M.B., Olsen, L.H., Häggström, J., Höglund, K., Ljungvall, I., Falk, T., Wess, G., Stephenson, H., Dukes-McEwan, J., Chetboul, V., Gouni, V., Proschowsky, H.F., Cirera, S., Karlskov-Mortensen, P., Fredholm, M. : | |
| Identification of 2 loci associated with development of myxomatous mitral valve disease in Cavalier King Charles Spaniels. J Hered 102 Suppl 1:S62-7, 2011. Pubmed reference: 21846748. DOI: 10.1093/jhered/esr041. | |
| 2010 | Borgarelli, M., Haggstrom, J. : |
| Canine degenerative myxomatous mitral valve disease: natural history, clinical presentation and therapy. Vet Clin North Am Small Anim Pract 40:651-63, 2010. Pubmed reference: 20610017. DOI: 10.1016/j.cvsm.2010.03.008. | |
| Lundin, T., Kvart, C. : | |
| Evaluation of the Swedish breeding program for cavalier King Charles spaniels. Acta Vet Scand 52:54, 2010. Pubmed reference: 20863375. DOI: 10.1186/1751-0147-52-54. | |
| 2009 | Aupperle, H., Thielebein, J., Kiefer, B., März, I., Dinges, G., Schoon, H.A., Schubert, A. : |
| Expression of genes encoding matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in normal and diseased canine mitral valves. J Comp Pathol 140:271-7, 2009. Pubmed reference: 19285315. DOI: 10.1016/j.jcpa.2009.01.001. | |
| Chetboul, V., Serres, F., Tissier, R., Lefebvre, HP., Sampedrano, CC., Gouni, V., Poujol, L., Hawa, G., Pouchelon, JL. : | |
| Association of plasma N-terminal pro-B-type natriuretic peptide concentration with mitral regurgitation severity and outcome in dogs with asymptomatic degenerative mitral valve disease. J Vet Intern Med 23:984-94, 2009. Pubmed reference: 19572913. DOI: 10.1111/j.1939-1676.2009.0347.x. | |
| Zheng, J., Chen, Y., Pat, B., Dell'italia, L.A., Tillson, M., Dillon, A.R., Powell, P.C., Shi, K., Shah, N., Denney, T., Husain, A., Dell'Italia, L.J. : | |
| Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog. Circulation 119:2086-95, 2009. Pubmed reference: 19349319. DOI: 10.1161/CIRCULATIONAHA.108.826230. | |
| 2008 | Borgarelli, M., Savarino, P., Crosara, S., Santilli, R.A., Chiavegato, D., Poggi, M., Bellino, C., La Rosa, G., Zanatta, R., Haggstrom, J., Tarducci, A. : |
| Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease. J Vet Intern Med 22:120-8, 2008. Pubmed reference: 18289298. DOI: 10.1111/j.1939-1676.2007.0008.x. | |
| 2006 | Oyama, M.A., Chittur, S.V. : |
| Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease. Am J Vet Res 67:1307-18, 2006. Pubmed reference: 16881841. DOI: 10.2460/ajvr.67.8.1307. | |
| 2004 | Borgarelli, M., Zini, E., D'Agnolo, G., Tarducci, A., Santilli, R.A., Chiavegato, D., Tursi, M., Prunotto, M., Häggström, J. : |
| Comparison of primary mitral valve disease in German Shepherd dogs and in small breeds. J Vet Cardiol 6:27-34, 2004. Pubmed reference: 19083307. DOI: 10.1016/S1760-2734(06)70055-8. | |
| Chetboul, V., Tissier, R., Villaret, F., Nicolle, A., Déan, E., Benalloul, T., Pouchelon, J.L. : | |
| [Epidemiological, clinical, echo-doppler characteristics of mitral valve endocardiosis in Cavalier King Charles in France: a retrospective study of 451 cases (1995 to 2003)]. Can Vet J 45:1012-5, 2004. Pubmed reference: 15646848. | |
| Häggström, J., Duelund Pedersen, H., Kvart, C. : | |
| New insights into degenerative mitral valve disease in dogs. Vet Clin North Am Small Anim Pract 34:1209-26, vii-viii, 2004. Pubmed reference: 15325478. DOI: 10.1016/j.cvsm.2004.05.002. | |
| Tarnow, I., Kristensen, AT., Olsen, LH., Pedersen, HD. : | |
| Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve disease. Am J Vet Res 65:1644-52, 2004. Pubmed reference: 15631028. | |
| 2003 | Kvart, C., Haggstrom, J., Pedersen, H.D. : |
| [ACE inhibitors in dogs with subclinical chronic mitral insufficiency] Tijdschrift voor Diergeneeskunde 128:76-7, 2003. Pubmed reference: 12616901. | |
| Olsen, L.H., Martinussen, T., Pedersen, H.D. : | |
| Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds Veterinary Record 152:293-7, 2003. Pubmed reference: 12650472. | |
| 2002 | Hagel, T., Deinert, M., Distl, O. : |
| Chronic mitral valve insufficiency in the cavalier King Charles spaniel Praktische Tierarzt 83:1056-+, 2002. | |
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