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OMIA:001226-9913 : Polymelia in Bos taurus (taurine cattle)

In other species: chicken , dog , sheep , Swainson's hawk

Categories: Limbs / fins / digit / tail phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Key variant is published: no

Cross-species summary: Supernumerary limbs.

Species-specific description: Angus calves with polymelia (Denholm and Martin, 2011) were the first signs and are still a major component of a disorder now called Developmental Duplications (DD); see OMIA 002103-9913.

Mapping: Neupane et al. (2017) conducted a GWAS on Friesians that identified candidate regions on chromosomes BTA10 and BTA13, which indicate that this disorder in Friesians is genetically different from Developmental Duplications (DD; see OMIA 002103-9913) in Angus, for which polymelia is one component, but which maps to the NHLRC2 locus on chromosome BTA26.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2017). OMIA:001226-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Mee, J.F., Murphy, D., Curran, M. :
Bovine congenital defects recorded by veterinary practitioners. Reprod Domest Anim 59:e14501, 2024. Pubmed reference: 37975255. DOI: 10.1111/rda.14501.
2019 Morath-Huss, U., Drögemüller, C., Stoffel, M., Precht, C., Zanolari, P., Spadavecchia, C. :
Polymelia in a chimeric Simmental calf: nociceptive withdrawal reflex, anaesthetic and analgesic management, anatomic and genetic analysis. BMC Vet Res 15:102, 2019. Pubmed reference: 30922306. DOI: 10.1186/s12917-019-1846-4.
2017 Neupane, M., Moss, K.D., Avila, F., Raudsepp, T., Marron, B.M., Beever, J.E., Parish, S., Kiser, J.N., Cantrell, B., Neibergs, H.L. :
Case Study: Polymelia in a Holstein calf Professional Animal Scientist , 2017. DOI: 10.15232/pas.2016-01594.
2011 Denholm, L.J., Martin, L.E. :
Polymelia (supernumerary limbs) in Angus calves Flock and Herd case notes; http://www.flockandherd.net.au/cattle/reader/polymelia.html , 2011.
2007 Nowacka, J., Urbaniak, K., Antosik, P., Jaskowski, JM., Frackowiak, H., Switonski, M. :
Polymelia associated with frequent chromosome breaks in a heifer. Vet Rec 161:276-7, 2007. Pubmed reference: 17720968.
2002 Hirsbrunner, G., Keller, Ch., Dolf, G. :
[Polymelia in a Holstein Friesian calf]. Schweiz Arch Tierheilkd 144:289-91, 2002. Pubmed reference: 12125240.
2001 Kim, C.S., Yeon, S.C., Cho, G.H., Lee, J.H., Choi, M.C., Won, C.G., Kim, J.G., Lee, S.R. :
Polymelia with two extra forelimbs at the right scapular region in a male Korean native calf Journal of Veterinary Medical Science 63:1161-1164, 2001. Pubmed reference: 11714039.
1993 Behrens, C., Kuczka, A., Grunert, E. :
[An unusual combination of different organ and skeletal abnormalities in a black and white calf]. Tierarztl Prax 21:185-7, 1993. Pubmed reference: 8346519.
1985 Johnston, A. :
Polymelia in a Hereford-cross calf. Vet Rec 116:585-6, 1985. Pubmed reference: 4013047.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 16 Sep 2013
  • Changed by Frank Nicholas on 10 Sep 2014
  • Changed by Frank Nicholas on 01 May 2017
  • Changed by Frank Nicholas on 04 May 2017
  • Changed by Frank Nicholas on 11 Sep 2017