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OMIA:001923-9615 : Spinal intradural arachnoid cyst in Canis lupus familiaris (dog)

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 182990 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also called 'spinal arachnoid diverticula'.  Characterized by the focal accumulation of cerebrospinal fluid (CSF) in the subarachnoid space, causing spinal cord compression and myelopathic clinical signs. Congenital or acquired causes are suspected.

Inheritance: Rohdin et al. (2014) reported that "Seven related young pugs were diagnosed with cervical spinal intradural arachnoid cysts by magnetic resonance imaging (n=6) and myelography (n=1)" and that "Pedigree analysis suggested a genetic predisposition for spinal arachnoid cysts in this family of pugs"

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: French Bulldog (Dog) (VBO_0201455), Pug (Dog) (VBO_0201089), Rottweiler (Dog) (VBO_0201143).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001923-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 De Frias, J.M., De Decker, S., De Stefani, A., Llabres-Diaz, F. :
Description and clinical relevance of the variable conformation of canine spinal arachnoid diverticula. Vet Radiol Ultrasound , 2024. Pubmed reference: 38572892. DOI: 10.1111/vru.13365.
Pilkington, E.J., De Decker, S., Skovola, E., Cloquell Miro, A., Gutierrez Quintana, R., Faller, K.M.E., Aguilera Padros, A., Goncalves, R. :
Prevalence, clinical presentation, and etiology of myelopathies in 224 juvenile dogs. J Vet Intern Med , 2024. Pubmed reference: 38483074. DOI: 10.1111/jvim.17045.
2020 Smith, C.J., Guevar, J. :
Spinal subarachnoid diverticula in dogs: A review. Can Vet J 61:1162-1169, 2020. Pubmed reference: 33149353.
2019 Alisauskaite, N., Cizinauskas, S., Jeserevics, J., Rakauskas, M., Cherubini, G.B., Anttila, M., Steffen, F. :
Short- and long-term outcome and magnetic resonance imaging findings after surgical treatment of thoracolumbar spinal arachnoid diverticula in 25 Pugs. J Vet Intern Med 33:1376-1383, 2019. Pubmed reference: 30844093. DOI: 10.1111/jvim.15470.
2018 de Nies, K.S., Edwards, R.A., Bergknut, N., Beukers, M., Meij, B.P. :
Caudal lumbar spinal cysts in two French Bulldogs. Acta Vet Scand 60:14, 2018. Pubmed reference: 29490674. DOI: 10.1186/s13028-018-0368-6.
2017 Mayousse, V., Desquilbet, L., Jeandel, A., Blot, S. :
Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002-2016). BMC Vet Res 13:212, 2017. Pubmed reference: 28676057. DOI: 10.1186/s12917-017-1132-2.
2016 da Costa, R.C., Cook, L.B. :
Cystic abnormalities of the spinal cord and vertebral column. Vet Clin North Am Small Anim Pract 46:S0195-5616(15)00167-9:277-93, 2016. Pubmed reference: 26706913. DOI: 10.1016/j.cvsm.2015.10.010.
2014 Lowrie, M.L., Platt, S.R., Garosi, L.S. :
Extramedullary spinal cysts in dogs. Vet Surg 43:650-62, 2014. Pubmed reference: 24798122. DOI: 10.1111/j.1532-950X.2014.12200.x.
Mauler, D.A., De Decker, S., De Risio, L., Volk, H.A., Dennis, R., Gielen, I., Van der Vekens, E., Goethals, K., Van Ham, L. :
Signalment, clinical presentation, and diagnostic findings in 122 dogs with spinal arachnoid diverticula. J Vet Intern Med 28:175-81, 2014. Pubmed reference: 24428321. DOI: 10.1111/jvim.12241.
Rohdin, C., Nyman, H.T., Wohlsein, P., Hultin Jäderlund, K. :
Cervical spinal intradural arachnoid cysts in related, young pugs. J Small Anim Pract 55:229-34, 2014. Pubmed reference: 24372140. DOI: 10.1111/jsap.12167.

Edit History


  • Created by Frank Nicholas on 23 Jun 2014
  • Changed by Imke Tammen2 on 06 Apr 2024