OMIA:001968-9615 : Height, HMGA2-associated body-size variation in Canis lupus familiaris (dog) |
In other species: horse
Categories: Growth / size / body region phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600698 (gene) , 611547 (trait) , 618908 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: no
Key variant known: no
Cross-species summary: Height has frequently been used as a textbook example for a polygenic trait. In humans, hundreds of loci with relatively small effects have been identified. In several domestic animal species, a handful of genetic loci has been repeatedly found to have comparatively large effects on height and/or body size.
Molecular basis: Rimbault et al. (2013) identified a "SNP in the 5′ UTR of HMGA2" that has a substantial effect on body size.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | Canis lupus familiaris | 10 | NC_051814.1 (8459176..8604625) | HMGA2 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:001968-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2019 | Hayward, J.J., White, M.E., Boyle, M., Shannon, L.M., Casal, M.L., Castelhano, M.G., Center, S.A., Meyers-Wallen, V.N., Simpson, K.W., Sutter, N.B., Todhunter, R.J., Boyko, A.R. : |
| Imputation of canine genotype array data using 365 whole-genome sequences improves power of genome-wide association studies. PLoS Genet 15:e1008003, 2019. Pubmed reference: 31525180. DOI: 10.1371/journal.pgen.1008003. | |
| 2015 | Webster, M.T., Kamgari, N., Perloski, M., Hoeppner, M.P., Axelsson, E., Hedhammar, Å., Pielberg, G., Lindblad-Toh, K. : |
| Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds. BMC Genomics 16:474, 2015. Pubmed reference: 26100605. DOI: 10.1186/s12864-015-1702-2. | |
| 2013 | Rimbault, M., Beale, H.C., Schoenebeck, J.J., Hoopes, B.C., Allen, J.J., Kilroy-Glynn, P., Wayne, R.K., Sutter, N.B., Ostrander, E.A. : |
| Derived variants at six genes explain nearly half of size reduction in dog breeds. Genome Res , 2013. Pubmed reference: 24026177. DOI: 10.1101/gr.157339.113. |
Edit History
- Created by Frank Nicholas on 23 Apr 2016
- Changed by Frank Nicholas on 23 Apr 2016