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OMIA:002054-9823 : Cancer, RUNX-related in Sus scrofa (pig)

Categories: Neoplasm

Possibly relevant human trait(s) and/or gene(s) (MIM number): 600210 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Susceptibility to tumours in pigs has been created artificially by CRISPR/Cas9-mediated gene targeting of the tumour supressor RUNX3; producing genetically-modified organisms (GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
RUNX3 runt-related transcription factor 3 Sus scrofa - no genomic information (-..-) RUNX3 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002054-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Tanihara, F., Hirata, M., Otoi, T. :
Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025.
Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2016 Kang, J.T., Ryu, J., Cho, B., Lee, E.J., Yun, Y.J., Ahn, S., Lee, J., Ji, D.Y., Lee, K., Park, K.W. :
Generation of RUNX3 knockout pigs using CRISPR/Cas9-mediated gene targeting. Reprod Domest Anim , 2016. Pubmed reference: 27696566. DOI: 10.1111/rda.12775.

Edit History


  • Created by Frank Nicholas on 17 Oct 2016
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 25 Sep 2021
  • Changed by Imke Tammen2 on 26 Dec 2021
  • Changed by Imke Tammen2 on 18 Dec 2023