OMIA:000230-9615 : Corneal dystrophy in Canis lupus familiaris (dog) |
In other species: domestic cat , rabbit
Categories: Vision / eye phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Genetics Committee of the American College of Veterinary Opthalmologists (2021): "non-inflammatory corneal opacity (white to gray) present in one or more of the corneal layers (epithelium, stroma, endothelium). The term dystrophy implies an inherited condition. It is usually bilateral although not necessarily symmetrical and the onset in one eye may precede the other."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breeds:
Beagle (Dog) (VBO_0200131),
German Shorthaired Pointer (Dog) (VBO_0200583),
German Wirehaired Pointer (Dog) (VBO_0200602).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000230-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2021 | Genetics Committee of the American College of Veterinary Opthalmologists : |
| The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf , 2021. | |
| 2020 | Schuh, J.C.L., Holve, D.L., Mundwiler, K.E. : |
| Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy. Toxicol Pathol 49:555-568, 2020. Pubmed reference: 33287658. DOI: 10.1177/0192623320968092. | |
| 2018 | Shull, O.R., Reilly, C.M., Davis, L.B., Murphy, C.J., Thomasy, S.M. : |
| Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology. Cornea 37:88-94, 2018. Pubmed reference: 29077583. DOI: 10.1097/ICO.0000000000001431. | |
| 1990 | Cooley, P.L., Dice, P.F. : |
| Corneal dystrophy in the dog and cat. Veterinary Clinics of North America-Small Animal Practice 20:681-692, 1990. | |
| 1988 | Green, W.R., Crispin, S.M. : |
| Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Cornea 7:149-61, 1988. Pubmed reference: 3261227. DOI: 10.1097/00003226-198802000-00011. | |
| 1982 | Spangler, W.L., Waring, G.O., Morrin, L.A. : |
| Oval lipid corneal opacities in Beagles: V. Ultrastructure. Veterinary Pathology 19:150-159, 1982. | |
| 1981 | Roth, A.M., Ekins, M.B., Waring, G.O., Gupta, L.M., Rosenblatt, L.S. : |
| Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia. Invest Ophthalmol Vis Sci 21:95-106, 1981. Pubmed reference: 7251305. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 18 Dec 2020
- Changed by Imke Tammen2 on 17 Jun 2023