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OMIA:001990-9541 : Cancer, TP53-related in Macaca fascicularis (crab-eating macaque)

In other species: dog , pig , golden hamster

Categories: Neoplasm

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 109800 (trait) , 114480 (trait) , 137215 (trait) , 601626 (trait) , 211980 (trait) , 260350 (trait) , 614470 (trait) , 202300 (trait) , 114500 (trait) , 114550 (trait) , 607107 (trait) , 259500 (trait) , 614740 (trait) , 137800 (trait) , 191170 (gene) , 190070 (gene) , 151623 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2015

Species-specific description: Wan et al. (2015) produced the first live p53 homozygous mutant monkey using CRISPR/Cas9 technology. This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TP53 tumor protein p53 Macaca fascicularis 16 NC_052270.1 (69909312..69928293) TP53 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001990-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2015 Wan, H., Feng, C., Teng, F., Yang, S., Hu, B., Niu, Y., Xiang, A.P., Fang, W., Ji, W., Li, W., Zhao, X., Zhou, Q. :
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res 25:258-261, 2015. Pubmed reference: 25430965. DOI: 10.1038/cr.2014.158.

Edit History


  • Created by Imke Tammen2 on 12 Sep 2022
  • Changed by Imke Tammen2 on 12 Sep 2022
  • Changed by Imke Tammen2 on 18 Dec 2023