In other species: crab-eating macaque , dog , domestic cat , horse , pig , Western roe deer , white-tailed deer , taurine cattle , sheep , rabbit , degu , markhor , springbok

Categories: Renal / urinary system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 173900 (trait) , 601313 (gene)

Links to MONDO diseases:

• MONDO:0008263: polycystic kidney disease 1

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: PKD

Species-specific description: Gerhauser et al. (2009) report "the case of a 19-year-old male lion (Panthera leo) with polycystic lesions in liver and kidney." (Compiled by Natalia Denisse Ramos Reyes 7/11/2022)

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: Gerhauser et al. (2009): “The animal suffered from inappetence and progressing hindlimb weakness and was euthanized due to poor prognosis.”

Pathology: Gerhauser et al. (2009): “Necropsy revealed multiple large, cystic cavities in the liver and numerous cysts in the renal cortex. Hepatic and renal cysts were lined by a flattened or cuboidal single-layered epithelium and derived from hepatic bile ducts and renal tubular structures, respectively, as confirmed by immunohistochemistry for the detection of different cytokeratins and carcinoembryonic antigen.”