OMIA:002587-9615 : Neoplasm, generic in Canis lupus familiaris (dog) |
In other species: Nile tilapia , middle-African hedgehog , African hunting dog , giant panda , domestic cat , elephants , horse , pig , Arabian camel , giraffe , taurine cattle , rabbit , golden hamster , long-tailed chinchilla , fishing cat , maned wolf , Amur leopard cat , southern giant pouched rat
Categories: Neoplasm
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Considered a defect: yes
Key variant known: no
Cross-species summary: Renamed [8/7/2023] from 'cancer, generic'. This phene includes information about benign (not cancer) or malignant (cancer) neoplasm that may or may not have a genetic predisposition.
Molecular basis: Rodrigues et al. (2023): "we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types ... . We discovered [somatic] mutations in 50 well-established oncogenes and tumor suppressors, and compared them to those reported in human cancers. As in human cancer, TP53 is the most commonly mutated gene, detected in 22.5% of canine tumors overall. Canine tumors share mutational hotspots with human tumors in oncogenes including PIK3CA, KRAS, NRAS, BRAF, KIT and EGFR. Hotspot mutations with significant association to tumor type include NRAS G61R and PIK3CA H1047R in hemangiosarcoma, ERBB2 V659E in pulmonary carcinoma, and BRAF V588E (equivalent of V600E in humans) in urothelial carcinoma."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002587-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Bugiel-Stabla, K., Agnoli, C., Pawlak, A. : |
| Estrogen receptors alpha and beta expression in different canine cancer types with an emphasis on hematopoietic malignancies. Vet Res Commun , 2024. Pubmed reference: 38594602. DOI: 10.1007/s11259-024-10368-2. | |
| Chon, E., Hendricks, W., White, M., Rodrigues, L., Haworth, D., Post, G. : | |
| Precision Medicine in Veterinary Science. Vet Clin North Am Small Anim Pract :S0195-5616(23)00174-2, 2024. Pubmed reference: 38212188. DOI: 10.1016/j.cvsm.2023.12.006. | |
| Eto, S., Shinada, M., Saeki, K., Tsuboi, M., Kamoto, S., Yoshitake, R., Chambers, J., Uchida, K., Kato, D., Nishimura, R., Nakagawa, T. : | |
| Pan-tumour analysis of COX-2 expression in dogs. Vet J :S1090-0233(24)00003-0:106064, 2024. Pubmed reference: 38242282. DOI: 10.1016/j.tvjl.2024.106064. | |
| Harmanci, A.S., Boudreau, B., Lau, S., Hosseingholi Nouri, S., Mandel, J.J., Lu, H.C., Harmanci, A.O., Klisch, T.J., Levine, J.M., Patel, A.J. : | |
| Aggressive human MenG C meningiomas have a molecular counterpart in canines. Acta Neuropathol 147:42, 2024. Pubmed reference: 38376654. DOI: 10.1007/s00401-024-02692-3. | |
| Kehl, A., Aupperle-Lellbach, H., de Brot, S., van der Weyden, L. : | |
| Review of Molecular Technologies for Investigating Canine Cancer. Animals (Basel) 14:769, 2024. Pubmed reference: 38473154. DOI: 10.3390/ani14050769. | |
| Kim, S.H., Baek, Y.B., Park, S.I. : | |
| Canine multiple primary tumours: Mammary tubular carcinoma, uterine leiomyosarcoma, and facial sebaceous epithelioma. Vet Med (Praha) 69:94-98, 2024. Pubmed reference: 38623156. DOI: 10.17221/103/2023-VETMED. | |
| Mochizuki, H., Estrada, A.J., Boggess, M. : | |
| Assessment of Y chromosome copy number alterations in non-neoplastic and neoplastic leukocytes of male dogs. Vet J :S1090-0233(24)00027-3:106088, 2024. Pubmed reference: 38412887. DOI: 10.1016/j.tvjl.2024.106088. | |
| Nelissen, S., Miller, A.D. : | |
| Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins. Vet Pathol :3009858241231562, 2024. Pubmed reference: 38366813. DOI: 10.1177/03009858241231562. | |
| Nunney, L. : | |
| The effect of body size and inbreeding on cancer mortality in breeds of the domestic dog: a test of the multi-stage model of carcinogenesis. R Soc Open Sci 11:231356, 2024. Pubmed reference: 38298404. DOI: 10.1098/rsos.231356. | |
| Santiago-Rodriguez, T.M. : | |
| Comparative oncology using domesticated dogs and their microbiome. Front Vet Sci 11:1378551, 2024. Pubmed reference: 38605920. DOI: 10.3389/fvets.2024.1378551. | |
| Wang, Z., Davidsen, T.M., Kuffel, G.R., Addepalli, K., Bell, A., Casas-Silva, E., Dingerdissen, H., Farahani, K., Fedorov, A., Gaheen, S., Grossman, R.L., Kikinis, R., Kim, E., Otridge, J., Pihl, T., Porter, M., Rodriguez, H., Staudt, L.M., Thangudu, R.R., Venkatachari, S., Zenklusen, J.C., Zhang, X., Barnholtz-Sloan, J.S., Crdc Program, T., Kerlavage, A.R. : | |
| NCI cancer research data commons: Resources to share key cancer data. Cancer Res , 2024. Pubmed reference: 38488507. DOI: 10.1158/0008-5472.CAN-23-2468. | |
| Zakimi, N., Mazcko, C.N., Toedebusch, C., Tawa, G., Woolard, K., LeBlanc, A.K., Dickinson, P.J., Raleigh, D.R. : | |
| Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas. Acta Neuropathol 147:43, 2024. Pubmed reference: 38376604. DOI: 10.1007/s00401-024-02693-2. | |
| 2023 | Arendt, M.L., Dobson, J.M. : |
| Sarcoma predisposition in dogs with a comparative view to human orthologous disease. Vet Sci 10:476, 2023. Pubmed reference: 37505880. DOI: 10.3390/vetsci10070476. | |
| Asari, Y., Yamazaki, J., Thandar, O., Suzuki, T., Aoshima, K., Takeuchi, K., Kinoshita, R., Kim, S., Hosoya, K., Ishizaki, T., Kagawa, Y., Jelinek, J., Yokoyama, S., Sasaki, N., Ohta, H., Nakamura, K., Takiguchi, M. : | |
| Diverse genome-wide DNA methylation alterations in canine hepatocellular tumours. Vet Med Sci 9:2006-2014, 2023. Pubmed reference: 37483163. DOI: 10.1002/vms3.1204. | |
| Athey, J.M., Vieson, M.D., Bailey, K., Rudmann, D., Baumgartner, W.A., Selting, K.A. : | |
| Canine thyroid carcinomas: A review with emphasis on comparing the compact subtype of follicular thyroid carcinomas and medullary thyroid carcinomas. Vet Pathol :3009858231177225, 2023. Pubmed reference: 37306003. DOI: 10.1177/03009858231177225. | |
| Barrantes Murillo, D.F., Newsom, E., Edwards, J.F., Joiner, K. : | |
| Unilateral vascular hamartomas of the vaginal tunic in a dog. J Vet Diagn Invest 35:568-572, 2023. Pubmed reference: 37395186. DOI: 10.1177/10406387231184841. | |
| Brady, R.V., Thamm, D.H. : | |
| Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs. Front Immunol 14:1176807, 2023. Pubmed reference: 37090720. DOI: 10.3389/fimmu.2023.1176807. | |
| Brunetti, B., de Biase, D., Dellapina, G., Muscatello, L.V., Ingravalle, F., Tura, G., Bacci, B. : | |
| Validation of p53 immunohistochemistry (PAb240 clone) in canine tumors with next-generation sequencing (NGS) analysis. Animals (Basel) 13:899, 2023. Pubmed reference: 36899756. DOI: 10.3390/ani13050899. | |
| Choi, Y., Nam, M.W., Lee, H.K., Choi, K.C. : | |
| Use of cutting-edge RNA-sequencing technology to identify biomarkers and potential therapeutic targets in canine and feline cancers and other diseases. J Vet Sci 24:e71, 2023. Pubmed reference: 38031650. DOI: 10.4142/jvs.23036. | |
| Chon, E., Wang, G., Whitley, D., Sakthikumar, S., Warrier, M., Wong, S., Duran, N., Adkins, J., Boateng, M., Zhu, Z., Facista, S., Haworth, D., Hendricks, W. : | |
| Genomic tumor analysis provides clinical guidance for the management of diagnostically challenging cancers in dogs. J Am Vet Med Assoc :1-10, 2023. Pubmed reference: 36862546. DOI: 10.2460/javma.22.11.0489. | |
| Chon, E., Sakthikumar, S., Tang, M., Hamilton, M.J., Vaughan, A., Smith, A., Sommer, B., Robat, C., Manley, C., Mullin, C., Ohashi, E., Manor, E., Custis, J., Intile, J., Shiu, K.B., Parshley, L., Bergman, N., Sheppard-Olivares, S., Hafeman, S., Wright, Z., Haworth, D., Hendricks, W., Wang, G. : | |
| Novel genomic prognostic biomarkers for dogs with cancer. J Vet Intern Med 37:2410-2421, 2023. Pubmed reference: 37801037. DOI: 10.1111/jvim.16893. | |
| da Silva, J., Cross, B.J. : | |
| Dog life spans and the evolution of aging. Am Nat 201:E140-E152, 2023. Pubmed reference: 37229711. DOI: 10.1086/724384. | |
| Das, S., Idate, R., Lana, S.E., Regan, D.P., Duval, D.L. : | |
| Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions. Sci Rep 13:10422, 2023. Pubmed reference: 37369741. DOI: 10.1038/s41598-023-37266-y. | |
| Hernández-Suárez, B., Gillespie, D.A., Dejnaka, E., Kupczyk, P., Obmińska-Mrukowicz, B., Pawlak, A. : | |
| Studying the DNA damage response pathway in hematopoietic canine cancer cell lines, a necessary step for finding targets to generate new therapies to treat cancer in dogs. Front Vet Sci 10:1227683, 2023. Pubmed reference: 37655260. DOI: 10.3389/fvets.2023.1227683. | |
| Knapp, D.W., Dhawan, D., Ruple, A., Cooper, B.R., Zhang, M., Liu, D., Ramos-Vara, J.A., Bonney, P.L., Fourez, L.M., Enstrom, A.W., Lahrman, S.A., Tullius, J.A. : | |
| Association between cigarette smoke exposure and urinary bladder cancer in Scottish terriers in a cohort study. Vet J :106044, 2023. Pubmed reference: 38000695. DOI: 10.1016/j.tvjl.2023.106044. | |
| Kruglyak, K.M., O'Kell, A.L., Cohen, T.A., Marshall, M.A., Ruiz-Perez, C.A., Marass, F., Tynan, J.A., Hicks, S.C., Lytle, K.M., Phelps-Dunn, A., Brandstetter, G., Warren, C.D., DiMarzio, L.R., Rosentel, M.C., Wong, L.K., McLennan, L.M., Rafalko, J.M., Grosu, D.S., Chibuk, J., Chorny, I., McCleary-Wheeler, A.L., Flory, A., Tsui, D.W.Y. : | |
| Detection of age-related somatic alterations in canine blood using next-generation sequencing-based liquid biopsy: An analysis of over 4800 dogs. Vet Sci 10:455, 2023. Pubmed reference: 37505860. DOI: 10.3390/vetsci10070455. | |
| Lin, Z., Zhang, J., Chen, Q., Zhang, X., Zhang, D., Lin, J., Lin, D. : | |
| Transcriptome analysis of the adenoma-carcinoma sequences identifies novel biomarkers associated with development of canine colorectal cancer. Front Vet Sci 10:1192525, 2023. Pubmed reference: 38098990. DOI: 10.3389/fvets.2023.1192525. | |
| Lin, Z., Chen, Q., Zhou, J., Zhang, J., Zhang, X., Zhang, D., Lin, J., Lin, D. : | |
| Transcriptomic analysis reveals immune infiltration status and potential biomarkers of canine colorectal cancer. Vet Immunol Immunopathol 262:110622, 2023. Pubmed reference: 37478614. DOI: 10.1016/j.vetimm.2023.110622. | |
| London, C.A., Gardner, H., Zhao, S., Knapp, D.W., Utturkar, S.M., Duval, D.L., Chambers, M.R., Ostrander, E., Trent, J.M., Kuffel, G. : | |
| Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology. Vet Comp Oncol , 2023. Pubmed reference: 37778398. DOI: 10.1111/vco.12935. | |
| Long, J., Ganakammal, S.R., Jones, S.E., Kothandaraman, H., Dhawan, D., Ogas, J., Knapp, D.W., Beyers, M., Lanman, N.A. : | |
| cTULIP: application of a human-based RNA-seq primary tumor classification tool for cross-species primary tumor classification in canine. Front Oncol 13:1216892, 2023. Pubmed reference: 37546395. DOI: 10.3389/fonc.2023.1216892. | |
| Marzec-Owczarek, M., Kandefer-Gola, M., Janus, I., Bubak, J., Nowak, M. : | |
| Expression of Foxp3 in fibromas and fibrosarcomas of skin and subcutaneous tissue in dogs. In Vivo 37:618-624, 2023. Pubmed reference: 36881099. DOI: 10.21873/invivo.13120. | |
| Medeiros-Fonseca, B., Faustino-Rocha, A.I., Medeiros, R., Oliveira, P.A., Gil da Costa, R.M. : | |
| Canine and feline papillomaviruses: an update. Front Vet Sci 10:1174673, 2023. Pubmed reference: 37261110. DOI: 10.3389/fvets.2023.1174673. | |
| Meuten, T.K., Dean, G.A., Thamm, D.H. : | |
| Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer. Vet Pathol :3009858231207021, 2023. Pubmed reference: 37905509. DOI: 10.1177/03009858231207021. | |
| Miyanishi, K., Nururrozi, A., Igase, M., Tanabe, M., Sakurai, M., Sakai, Y., Shimonohara, N., Murakami, M., Mizuno, T. : | |
| Activation of the Akt signalling pathway as a prognostic indicator in canine soft tissue sarcoma. J Comp Pathol 206:44-52, 2023. Pubmed reference: 37839309. DOI: 10.1016/j.jcpa.2023.08.007. | |
| Oh, J.H., Cho, J.Y. : | |
| Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3. | |
| Portanova, A., Rout, E.D., Avery, A.C., Viall, A.K. : | |
| Suspected primary bone marrow T-cell lymphoid neoplasia causing paraneoplastic hypercalcemia in 11 dogs (2014-2021). J Am Vet Med Assoc :1-9, 2023. Pubmed reference: 37922707. DOI: 10.2460/javma.23.07.0389. | |
| Rebhun, R.B., York, D., De Graaf, F.M.D., Yoon, P., Batcher, K.L., Luker, M.E., Ryan, S., Peyton, J., Kent, M.S., Stern, J.A., Bannasch, D.L. : | |
| A variant in the 5'UTR of ERBB4 is associated with lifespan in Golden Retrievers. Geroscience , 2023. Pubmed reference: 37855863. DOI: 10.1007/s11357-023-00968-2. | |
| Rodrigues, L., Watson, J., Feng, Y., Lewis, B., Harvey, G., Post, G., Megquier, K., White, M.E., Lambert, L., Miller, A., Lopes, C., Zhao, S. : | |
| Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics. Sci Rep 13:10935, 2023. Pubmed reference: 37414794. DOI: 10.1038/s41598-023-37505-2. | |
| Rodríguez, J., Santana, Á., Borzollino, M.A., Herráez, P., Killick, D.R., de Los Monteros, A.E. : | |
| Epidemiology of canine cutaneous round cell tumours on the canary archipelago in Spain. Vet Comp Oncol 21:406-418, 2023. Pubmed reference: 37143410. DOI: 10.1111/vco.12899. | |
| Sakthikumar, S., Warrier, M., Whitley, D., Facista, S., Adkins, J., Aman, S., Tsinajinnie, D., Duran, N., Siravegna, G., Ahmed, Z., Day, K., Jenkins, B., Patel, N., Ryden, K., Nadai, J., Banovich, K., Powers, B., Edwards, J., Steinberg, J., Fielder, S., Wong, S., Byron, S.A., Izatt, T., Zismann, V., Boateng, M., Zhu, Z., Chuang, H.Y., Trent, J.M., Haworth, D., Chon, E., Hendricks, W., Wang, G. : | |
| Genomic analysis across 53 canine cancer types reveals novel mutations and high clinical actionability potential. Vet Comp Oncol , 2023. Pubmed reference: 38053317. DOI: 10.1111/vco.12944. | |
| Sakthikumar, S., Facista, S., Whitley, D., Byron, S.A., Ahmed, Z., Warrier, M., Zhu, Z., Chon, E., Banovich, K., Haworth, D., Hendricks, W.P.D., Wang, G. : | |
| Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC. Vet Comp Oncol , 2023. Pubmed reference: 37248814. DOI: 10.1111/vco.12911. | |
| Satthathum, C., Srisampane, S., Jariyarangsrirattana, P., Anusorn, P., Sattasathuchana, P., Thengchaisri, N. : | |
| Characteristics of canine oral tumors: Insights into prevalence, types, and lesion distribution. J Adv Vet Anim Res 10:554-562, 2023. Pubmed reference: 37969809. DOI: 10.5455/javar.2023.j709. | |
| Shinada, M., Kato, D., Tsuboi, M., Ikeda, N., Aoki, S., Iguchi, T., Li, T., Kodera, Y., Ota, R., Koseki, S., Shibahara, H., Takahashi, Y., Hashimoto, Y., Chambers, J.K., Uchida, K., Noguchi, S., Kato, Y., Nishimura, R., Nakagawa, T. : | |
| Podoplanin promotes cell proliferation, survival, and migration of canine non-tonsillar squamous cell carcinoma. J Vet Med Sci 85:1068-1073, 2023. Pubmed reference: 37544715. DOI: 10.1292/jvms.23-0062. | |
| Śmiech, A., Bulak, K., Łopuszyński, W., Puła, A. : | |
| Incidence and the risk of occurrence of benign and malignant canine skin tumours in Poland - a five-year retrospective study. J Vet Res 67:437-446, 2023. Pubmed reference: 37786849. DOI: 10.2478/jvetres-2023-0048. | |
| Stevenson, V.B., Gudenschwager-Basso, E.K., Klahn, S., LeRoith, T., Huckle, W.R. : | |
| Inhibitory checkpoint molecule mRNA expression in canine soft tissue sarcoma. Vet Comp Oncol 21:709-716, 2023. Pubmed reference: 37680007. DOI: 10.1111/vco.12934. | |
| Tkaczyk-Wlizło, A., Kowal, K., Śmiech, A., Ślaska, B. : | |
| Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review. J Appl Genet , 2023. Pubmed reference: 38123735. DOI: 10.1007/s13353-023-00818-z. | |
| van den Berg, M.F., Kooistra, H.S., Grinwis, G.C.M., Nicoli, S., Golinelli, S., Stammeleer, L., van Wolferen, M.E., Timmermans-Sprang, E.P.M., Zandvliet, M.M.J.M., van Steenbeek, F.G., Galac, S. : | |
| Whole transcriptome analysis of canine pheochromocytoma and paraganglioma. Front Vet Sci 10:1155804, 2023. Pubmed reference: 37691636. DOI: 10.3389/fvets.2023.1155804. | |
| Wong, K., Abascal, F., Ludwig, L., Aupperle-Lellbach, H., Grassinger, J., Wright, C.W., Allison, S.J., Pinder, E., Phillips, R.M., Romero, L.P., Gal, A., Roady, P.J., Pires, I., Guscetti, F., Munday, J.S., Peleteiro, M.C., Pinto, C.A., Carvalho, T., Cota, J., Du Plessis, E.C., Constantino-Casas, F., Plog, S., Moe, L., de Brot, S., Bemelmans, I., Amorim, R.L., Georgy, S.R., Prada, J., Del Pozo, J., Heimann, M., de Carvalho Nunes, L., Simola, O., Pazzi, P., Steyl, J., Ubukata, R., Vajdovich, P., Priestnall, S.L., Suárez-Bonnet, A., Roperto, F., Millanta, F., Palmieri, C., Ortiz, A.L., Barros, C.S.L., Gava, A., Söderström, M.E., O'Donnell, M., Klopfleisch, R., Manrique-Rincón, A., Martincorena, I., Ferreira, I., Arends, M.J., Wood, G.A., Adams, D.J., van der Weyden, L. : | |
| Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer. Genome Biol 24:191, 2023. Pubmed reference: 37635261. DOI: 10.1186/s13059-023-03026-4. | |
| Zhang, Y., Wu, M., Zhou, J., Diao, H. : | |
| Long Non-Coding RNA as a Potential Biomarker for Canine Tumors. Vet Sci 10:637, 2023. Pubmed reference: 37999460. DOI: 10.3390/vetsci10110637. | |
| Zhou, B.W., Wu, Q.Q., Mauki, D.H., Wang, X., Zhang, S.R., Yin, T.T., Chen, F.L., Li, C., Liu, Y.H., Wang, G.D., Zhang, Y.P. : | |
| Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility. iScience 26:108431, 2023. Pubmed reference: 38205119. DOI: 10.1016/j.isci.2023.108431. | |
| Zucko, D., Boris-Lawrie, K. : | |
| Blocking tri-methylguanosine synthase 1 (TGS1) stops anchorage-independent growth of canine sarcomas. Cancer Gene Ther , 2023. Pubmed reference: 37386121. DOI: 10.1038/s41417-023-00636-9. | |
| Zuleger, C.L., Schwartz, R.W., Ong, I.M., Newton, M.A., Vail, D.M., Albertini, M.R. : | |
| Development of a next-generation sequencing protocol for the canine T cell receptor beta chain repertoire. Vet Immunol Immunopathol 268:S0165-2427(23)00156-3:110702, 2023. Pubmed reference: 38183837. DOI: 10.1016/j.vetimm.2023.110702. | |
| 2015 | Dugat, D.R., Medici, E.L., Rochat, M.C., Arble, J.A., Snider, T.A. : |
| An unusual case of metastatic seminoma in a dog. J Am Anim Hosp Assoc 51:401-6, 2015. Pubmed reference: 26535460. DOI: 10.5326/JAAHA-MS-6263. | |
| Slaska, B., Grzybowska-Szatkowska, L., Nisztuk, S., Surdyka, M., Rozanska, D. : | |
| Mitochondrial DNA polymorphism in genes encoding ND1, COI and CYTB in canine malignant cancers. Mitochondrial DNA 26:452-8, 2015. Pubmed reference: 24102599. DOI: 10.3109/19401736.2013.840594. | |
| 2014 | Slaska, B., Grzybowska-Szatkowska, L., Surdyka, M., Nisztuk, S., Rozanska, D., Rozanski, P., Smiech, A., Orzelski, M. : |
| Mitochondrial D-loop mutations and polymorphisms are connected with canine malignant cancers. Mitochondrial DNA 25:238-43, 2014. Pubmed reference: 23656294. DOI: 10.3109/19401736.2013.792054. |
Edit History
- Created by Imke Tammen2 on 16 Jan 2023
- Changed by Imke Tammen2 on 16 Jan 2023
- Changed by Imke Tammen2 on 20 Jul 2023