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OMIA:000411-9615 : Glaucoma, generic in Canis lupus familiaris (dog)

In other species: Rhesus monkey , domestic cat , tiger , horse , rabbit , owls , Japanese quail

Categories: Vision / eye phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 137700 (trait) , 137750 (trait) , 137760 (trait) , 137763 (trait) , 231300 (trait) , 231300 (trait) , 600510 (trait) , 600975 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Genetics Committee of the American College of Veterinary Opthalmologists (2021): Glaucoma is "characterized by an elevation of intraocular pressure (IOP) which causes optic nerve and retinal degeneration and results in blindness. Diagnosis and classification of glaucoma requires tonometry and gonioscopy, which are not part of a routine eye certification examination."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000411-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Bedos, L., Sandmeyer, L., Campbell, J., Grahn, B.H. :
Prevalence of pre-iridal monocellular and fibrovascular membranes in canine globes affected with congenital glaucoma associated with anterior segment dysgenesis, primary glaucoma associated with goniodysgenesis, and secondary glaucoma. Front Vet Sci 11:1289283, 2024. Pubmed reference: 38444777. DOI: 10.3389/fvets.2024.1289283.
2023 Leis, M.L., Grahn, B. :
Glaucoma associated with anterior segment dysgenesis in dogs and cats. Vet Clin North Am Small Anim Pract 53:423-437, 2023. Pubmed reference: 36813393. DOI: 10.1016/j.cvsm.2022.11.003.
Sandmeyer, L. :
The clinical approach to canine glaucoma. Vet Clin North Am Small Anim Pract 53:389-421, 2023. Pubmed reference: 36813392. DOI: 10.1016/j.cvsm.2022.10.005.
Sebbag, L., Pe'er, O. :
Role of inflammation in canine primary glaucoma. Animals (Basel) 14:110, 2023. Pubmed reference: 38200841. DOI: 10.3390/ani14010110.
2022 Gilger, B.C. :
How study of naturally occurring ocular disease in animals improves ocular health globally. J Am Vet Med Assoc 260:1887-1893, 2022. Pubmed reference: 36198052. DOI: 10.2460/javma.22.08.0383.
Gomes, F.E., Casanova, M.I., Mouttham, L., Bannasch, D.L., Park, S., Kim, S., Young, L.J., Daley, N.L., Thomasy, S.M., Castelhano, M.G., Ledbetter, E.C., Holmberg, B., Boyd, R., Van Der Woerdt, A., McDonald, J., Hayward, J.J. :
A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res :1-8, 2022. Pubmed reference: 36170212. DOI: 10.2460/ajvr.22.07.0106.
2021 Genetics Committee of the American College of Veterinary Opthalmologists :
The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf , 2021.
2017 Graham, K.L., McCowan, C., White, A. :
Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326. DOI: 10.1177/0300985816666611.
2016 Oliver, J.A., Ekiri, A., Mellersh, C.S. :
Prevalence of pectinate ligament dysplasia and associations with age, sex and intraocular pressure in the Basset hound, Flatcoated retriever and Dandie Dinmont terrier. Canine Genet Epidemiol 3:1, 2016. Pubmed reference: 26973793. DOI: 10.1186/s40575-016-0033-1.
2015 Komáromy, A.M., Petersen-Jones, S.M. :
Genetics of canine primary glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015. Pubmed reference: 26277300. DOI: 10.1016/j.cvsm.2015.06.003.
Pizzirani, S. :
Definition, classification, and pathophysiology of canine glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015. Pubmed reference: 26456751. DOI: 10.1016/j.cvsm.2015.06.002.
2014 Chen, T., Gionfriddo, J.R., Tai, P.Y., Novakowski, A.N., Alyahya, K., Madl, J.E. :
Oxidative stress increases in retinas of dogs in acute glaucoma but not in chronic glaucoma. Vet Ophthalmol , 2014. Pubmed reference: 24814303. DOI: 10.1111/vop.12177.
2013 Low, M.C., Landis, M.L., Peiffer, R.L. :
Intravitreal cidofovir injection for the management of chronic glaucoma in dogs. Vet Ophthalmol , 2013. Pubmed reference: 23763487. DOI: 10.1111/vop.12071.
Pumphrey, S.A., Pizzirani, S., Pirie, C.G., Anwer, M.S., Logvinenko, T. :
Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma. Am J Vet Res 74:621-8, 2013. Pubmed reference: 23531071. DOI: 10.2460/ajvr.74.4.621.
Wang, Q., Grozdanic, S.D., Harper, M.M., Hamouche, K., Hamouche, N., Kecova, H., Lazic, T., Hernandez-Merino, E., Yu, C. :
Detection and characterization of glaucoma-like canine retinal tissues using Raman spectroscopy. J Biomed Opt 18:67008, 2013. Pubmed reference: 23804216. DOI: 10.1117/1.JBO.18.6.067008.
2012 Bouhenni, R.A., Dunmire, J., Sewell, A., Edward, D.P. :
Animal models of glaucoma. J Biomed Biotechnol 2012:692609, 2012. Pubmed reference: 22665989. DOI: 10.1155/2012/692609.
Pumphrey, S.A., Pizzirani, S., Pirie, C.G., Needle, D.B. :
Glaucoma associated with uveal cysts and goniodysgenesis in American Bulldogs: a case series. Vet Ophthalmol , 2012. Pubmed reference: 23110479. DOI: 10.1111/vop.12000.
2011 Strom, A.R., Hässig, M., Iburg, T.M., Spiess, B.M. :
Epidemiology of canine glaucoma presented to University of Zurich from 1995 to 2009. Part 2: secondary glaucoma (217 cases). Vet Ophthalmol 14:127-32, 2011. Pubmed reference: 21366829. DOI: 10.1111/j.1463-5224.2010.00854.x.
Strom, A.R., Hässig, M., Iburg, T.M., Spiess, B.M. :
Epidemiology of canine glaucoma presented to University of Zurich from 1995 to 2009. Part 1: Congenital and primary glaucoma (4 and 123 cases). Vet Ophthalmol 14:121-6, 2011. Pubmed reference: 21366828. DOI: 10.1111/j.1463-5224.2010.00855.x.
2010 Grozdanic, SD., Kecova, H., Harper, MM., Nilaweera, W., Kuehn, MH., Kardon, RH. :
Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Invest Ophthalmol Vis Sci 51:255-63, 2010. Pubmed reference: 19661222. DOI: 10.1167/iovs.09-4081.
2009 Dzanis, D. :
Canine glaucoma: medical and surgical treatment options. Compend Contin Educ Vet 31:462-6, 2009. Pubmed reference: 20180215.
Esson, D., Armour, M., Mundy, P., Schobert, C.S., Dubielzig, R.R. :
The histopathological and immunohistochemical characteristics of pigmentary and cystic glaucoma in the Golden Retriever. Vet Ophthalmol 12:361-8, 2009. Pubmed reference: 19883466. DOI: 10.1111/j.1463-5224.2009.00732.x.
Reinstein, S., Rankin, A., Allbaugh, R. :
Canine glaucoma: pathophysiology and diagnosis. Compend Contin Educ Vet 31:450-3, 2009. Pubmed reference: 20180213.
Reinstein, S., Rankin, A., Allbaugh, R. :
Canine glaucoma: medical and surgical treatment options. Compend Contin Educ Vet 31:454-60, 2009. Pubmed reference: 20180214.
2006 Kato, K., Sasaki, N., Matsunaga, S., Mochizuki, M., Nishimura, R., Ogawa, H. :
Possible association of glaucoma with pectinate ligament dysplasia and narrowing of the iridocorneal angle in Shiba Inu dogs in Japan. Vet Ophthalmol 9:71-5, 2006. Pubmed reference: 16497230. DOI: 10.1111/j.1463-5224.2006.00438.x.
2005 Sapienza, JS., van der Woerdt, A. :
Combined transscleral diode laser cyclophotocoagulation and Ahmed gonioimplantation in dogs with primary glaucoma: 51 cases (1996-2004). Vet Ophthalmol 8:121-7, 2005. Pubmed reference: 15762925. DOI: 10.1111/j.1463-5224.2005.00356.x.
2004 Gelatt, K.N., MacKay, E.O. :
Prevalence of the breed-related glaucomas in pure-bred dogs in North America. Vet Ophthalmol 7:97-111, 2004. Pubmed reference: 14982589. DOI: 10.1111/j.1463-5224.2004.04006.x.
2002 Bjerkas, E., Ekesten, B., Farstad, W. :
Pectinate ligament dysplasia and narrowing of the iridocorneal angle associated with glaucoma in the English Springer Spaniel Veterinary Ophthalmology 5:49-54, 2002. Pubmed reference: 11940248.
1998 Read, R.A., Wood, J.L., Lakhani, K.H. :
Pectinate ligament dysplasia (PLD) and glaucoma in Flat Coated Retrievers. I. Objectives, technique and results of a PLD survey. Vet Ophthalmol 1:85-90, 1998. Pubmed reference: 11397215.
Wood, J.L., Lakhani, K.H., Read, R.A. :
Pectinate ligament dysplasia and glaucoma in Flat Coated Retrievers. II. Assessment of prevalence and heritability. Vet Ophthalmol 1:91-99, 1998. Pubmed reference: 11397216.
1996 Ruhli, M.B., Spiess, B.M. :
Goniodysgenesis in the bouvier des flandres dog [German] Schweizer Archiv fur Tierheilkunde 138:307-311, 1996. Pubmed reference: 8765546.
1995 Kural, E., Lindley, D., Krohne, S. :
Canine glaucoma .2 Compendium on Continuing Education for the Practicing Veterinarian 17:1253 ff., 1995.
Kural, E., Lindley, D., Krohne, S. :
Canine glaucoma .1 Compendium on Continuing Education for the Practicing Veterinarian 17:1017 ff., 1995.
1994 Spiess, B.M. :
[Inherited Ocular Diseases in the Entlebucher Mountain Dog] Schweizer Archiv Fur Tierheilkunde 136:105-110, 1994. Pubmed reference: 8171308.
1990 Brooks, D.E. :
Glaucoma in the Dog and Cat Veterinary Clinics of North America-Small Animal Practice 20:775-797, 1990. Pubmed reference: 2194358.
1987 van der Linde-Sipman, J.S. :
Dysplasia of the pectinate ligament and primary glaucoma in the Bouvier des Flandres dog. Vet Pathol 24:201-6, 1987. Pubmed reference: 3603960.
1986 Hedhammar, A. :
[Current situation regarding the eradication of genetically conditioned eye disorders in Sweden] Svensk Veterinartidning 38:152-160, 1986.
1968 Lovekin, L.G., Bellhorn, R.W. :
Clinicopathologic changes in primary glaucoma in the Cocker Spaniel American Journal of Veterinary Research 29:379-385, 1968.
Martin, C.L., Wyman, M. :
Glaucoma in the Basset Hound Journal of the American Veterinary Medical Association 153:1320-1327, 1968. Pubmed reference: 5748475.
1967 Roberts, S.R. :
Recognizing glaucoma: the appearance, course, and effects of the disease in clinical veterinary medicine Proceedings of the American Society of Veterinary Ophthalmology, Dallas :8-12, 1967.
1964 Lovekin, L.G. :
Primary glaucoma in dogs. J Am Vet Med Assoc 145:1081-91, 1964. Pubmed reference: 14235477.
1957 Magrane, W.G. :
Canine glaucoma. I. Methods of diagnosis. J Am Vet Med Assoc 131:311-4, 1957. Pubmed reference: 13475109.
Magrane, W.G. :
Canine glaucoma. II. Primary classification. J Am Vet Med Assoc 131:372-4, 1957. Pubmed reference: 13475121.
Magrane, W.G. :
Canine glaucoma. IV. Medical and surgical treatment Journal of the American Veterinary Medical Association 131:456-464, 1957. Pubmed reference: 13475134.
Magrane, W.G. :
Canine glaucoma. III. Secondary classification. J Am Vet Med Assoc 131:374-8, 1957. Pubmed reference: 13475122.
1950 Jourdan, R.H. :
Pathogenesis of canine glaucoma. J Am Vet Med Assoc 117:419-22, 1950. Pubmed reference: 14784441.

Edit History


  • Created by Frank Nicholas on 14 Apr 2010
  • Changed by Frank Nicholas on 05 Jan 2013
  • Changed by Frank Nicholas on 13 May 2013
  • Changed by Frank Nicholas on 22 Aug 2013
  • Changed by Imke Tammen2 on 17 Jun 2023