OMIA 000168-100936 : Cataract, generic in Chlorocebus aethiops vervet

In other species: domestic cat , cattle , dog , horse , sheep , domestic ferret , chicken , domestic guinea pig , lion , rabbit , crab-eating macaque , degu , bald eagle , giant panda

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Opacity of the lens of the eye.

Inheritance: Magwebu et al. (2018) reported that "The parents of the affected individuals were however observed to be asymptomatic, which confirmed that

this phenotype was transmitted in a recessive mode" but did not provide sufficient evidence to support the claimed inheritance.

Markers: Ngqaneka et al. (2020) identified several variants in functional candidate genes that "were found to be potentially disease-causing".

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Ngqaneka, T., Khoza, S., Magwebu, Z.E., Chauke, C.G. :
Mutational analysis of BFSP1, CRYBB1, GALK1, and GJA8 in captive-bred vervet monkeys (Chlorocebus aethiops). J Med Primatol :, 2020. Pubmed reference: 31975409. DOI: 10.1111/jmp.12455.
2018 Magwebu, Z.E., Abdul-Rasool, S., Seier, J.V., Chauke, C.G. :
Autosomal recessive congenital cataract in captive-bred vervet monkeys (Chlorocebus aethiops). J Med Primatol :, 2018. Pubmed reference: 29377145. DOI: 10.1111/jmp.12332.
2001 de Villiers, C., Seier, J.V., Dhansay, M.A. :
Probable genetic origin for a large number of cataracts among captive-bred vervet monkeys (Chlorocebus aethiops). Am J Primatol 55:43-8, 2001. Pubmed reference: 11536315. DOI: 10.1002/ajp.1037.

Edit History


  • Created by Frank Nicholas on 02 Feb 2018
  • Changed by Frank Nicholas on 26 Jan 2020