OMIA 001423-9940 : Fecundity, small tail Han in Ovis aries

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 609441 , 134720 , 300510

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2007

Molecular basis: Chu et al. (2007) showed that the fecundity of the Small Tailed Han breed is due to the segregation of the FecB(B) mutation (Q249R) in the BMPR1B gene (OMIA 000383-9940) and the FecX(G) mutation (Q239Ter) of the BMP15 gene (OMIA 000384-9940).

Breed: Han, small-tailed.

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
BMPR1B bone morphogenetic protein receptor type IB Ovis aries 6 NC_040257.1 (34214541..33988778) BMPR1B Homologene, Ensembl, NCBI gene
BMP15 bone morphogenetic protein 15 Ovis aries X NC_040278.1 (56601245..56594761) BMP15 Homologene, Ensembl, NCBI gene


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Chen, S., Guo, X., He, X., Di, R., Zhang, X., Zhang, J., Wang, X., Chu, M. :
Transcriptome analysis reveals differentially expressed genes and long non-coding RNAs associated with fecundity in sheep hypothalamus with different FecB genotypes. Front Cell Dev Biol 9:633747, 2021. Pubmed reference: 34095109. DOI: 10.3389/fcell.2021.633747.
2007 Chu, MX., Liu, ZH., Jiao, CL., He, YQ., Fang, L., Ye, SC., Chen, GH., Wang, JY. :
Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries). J Anim Sci 85:598-603, 2007. Pubmed reference: 17040942. DOI: 10.2527/jas.2006-324.
2005 Bi, XD., Chu, MX., Jin, HG., Fang, L., Ye, SC. :
[Estrogen receptor as a candidate gene for prolificacy of small tail Han sheep] Yi Chuan Xue Bao 32:1060-5, 2005. Pubmed reference: 16252701.
Chu, MX., Sang, LH., Wang, JY., Fang, L., Ye, SC. :
[Study on BMP15 and GDF9 as candidate genes for prolificacy of Small Tail Han sheep] Yi Chuan Xue Bao 32:38-45, 2005. Pubmed reference: 15715436.
2003 Liu, SF., Jiang, YL., Du, LX. :
[Studies of BMPR-IB and BMP15 as candidate genes for fecundity in little tailed han sheep] Yi Chuan Xue Bao 30:755-60, 2003. Pubmed reference: 14682245.

Edit History

  • Created by Frank Nicholas on 21 Nov 2005
  • Changed by Frank Nicholas on 09 Dec 2011
  • Changed by Frank Nicholas on 28 Jun 2013
  • Changed by Imke Tammen2 on 17 Jun 2021
  • Changed by Imke Tammen2 on 25 Jun 2021