Categories: Immune system phene

Possible human homologues (MIM numbers): 120950 (gene) , 613790 (trait)

Links to MONDO diseases:

• MONDO:0013422: type I complement component 8 deficiency

Cross-species summary: Complement component 8 consists of three peptides: the alpha, beta and gamma chains, each encoded by a separate locus. The alpha and beta chains are bound covalently through a disulphide link, forming the alpha-gamma subunit, which is non-covalently (i.e. weakly) associated with the beta chain. Disorders resulting from deficiency of the alpha-gamma subunit are called C8 deficiency, or C8 deficiency, type I; disorders resulting from deficiency of the beta chain are called C8 deficiency, type II.

Species in which this phene is found:
rabbit (Oryctolagus cuniculus)