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OMIA:000175-9940 : Cerebellar abiotrophy in Ovis aries (sheep)

In other species: dog , domestic cat , horse , taurine cattle , goat , Magellanic penguin

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 600224 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Cross-species summary: Also known as neonatal cerebellar cortical degeneration (NCCD)

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Charollais (Sheep) (VBO_0001368), Merino (Sheep) (VBO_0001508), Wiltshire Horn (Sheep) (VBO_0001688).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:000175-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2018 Scott, E.Y., Woolard, K.D., Finno, C.J., Murray, J.D. :
Cerebellar abiotrophy across domestic species. Cerebellum 17:372-379, 2018. Pubmed reference: 29294214. DOI: 10.1007/s12311-017-0914-1.
2005 Johnstone, AC., Johnson, CB., Malcolm, KE., Jolly, RD. :
Cerebellar cortical abiotrophy in Wiltshire sheep. N Z Vet J 53:242-5, 2005. Pubmed reference: 16044183. DOI: 10.1080/00480169.2005.36552.
1998 Milne, E.M., Schock, A. :
Cerebellar abiotrophy in a pedigree Charollais sheep flock Veterinary Record 143:224-225, 1998. Pubmed reference: 9770765.
1995 Bourke, C.A. :
The clinical differentiation of nervous and muscular locomotor disorders of sheep in Australia. Aust Vet J 72:228-34, 1995. Pubmed reference: 8526819.
1986 Harper, PA., Duncan, DW., Plant, JW., Smeal, MG. :
Cerebellar abiotrophy and segmental axonopathy: two syndromes of progressive ataxia of Merino sheep. Aust Vet J 63:18-21, 1986. Pubmed reference: 3954688.

Edit History


  • Created by Frank Nicholas on 17 Sep 2005
  • Changed by Imke Tammen2 on 27 Oct 2022