OMIA:000552-9615 : Immunoglobulin A deficiency in Canis lupus familiaris (dog) |
In other species: gray wolf
Categories: Immune system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Mapping: Olsson et al. (2015): "GWAS performed in four breeds prone to low IgA levels (German shepherd, Golden retriever, Labrador retriever and Shar-Pei) identified 35 genomic loci suggestively associated (p <0.0005) to IgA levels. In German shepherd, three genomic regions (candidate genes include KIRREL3 and SERPINA9) were genome-wide significantly associated (p <0.0002) with IgA levels. A ~20kb long haplotype on CFA28, significantly associated (p = 0.0005) to IgA levels in Shar-Pei, was positioned within the first intron of the gene SLIT1."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breeds:
Chinese Shar-Pei (Dog) (VBO_0200351),
German Shepherd Dog (Dog) (VBO_0200577),
Golden Retriever (Dog) (VBO_0200610),
Labrador Retriever (Dog) (VBO_0200800).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:000552-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2019 | Ellis, J.A. : |
| Canine IgA and IgA deficiency: Implications for immunization against respiratory pathogens. Can Vet J 60:1305-1311, 2019. Pubmed reference: 31814637. | |
| 2015 | Olsson, M., Tengvall, K., Frankowiack, M., Kierczak, M., Bergvall, K., Axelsson, E., Tintle, L., Marti, E., Roosje, P., Leeb, T., Hedhammar, Å., Hammarström, L., Lindblad-Toh, K. : |
| Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency. PLoS One 10:e0133844, 2015. Pubmed reference: 26225558. DOI: 10.1371/journal.pone.0133844. | |
| 2014 | Olsson, M., Frankowiack, M., Tengvall, K., Roosje, P., Fall, T., Ivansson, E., Bergvall, K., Hansson-Hamlin, H., Sundberg, K., Hedhammar, A., Lindblad-Toh, K., Hammarström, L. : |
| The dog as a genetic model for immunoglobulin A (IgA) deficiency: identification of several breeds with low serum IgA concentrations. Vet Immunol Immunopathol 160:255-9, 2014. Pubmed reference: 24935667. DOI: 10.1016/j.vetimm.2014.05.010. | |
| 2013 | Frankowiack, M., Hellman, L., Zhao, Y., Arnemo, J.M., Lin, M., Tengvall, K., Møller, T., Lindblad-Toh, K., Hammarström, L. : |
| IgA deficiency in wolves. Dev Comp Immunol 40:180-4, 2013. Pubmed reference: 23352622. DOI: 10.1016/j.dci.2013.01.005. | |
| 2003 | Norris, C.R., Gershwin, L.J. : |
| Evaluation of systemic and secretory IgA concentrations and immunohistochemical stains for IgA-containing B cells in mucosal tissues of an Irish setter with selective IgA deficiency Journal of the American Animal Hospital Association 39:247-50, 2003. Pubmed reference: 12755197. | |
| 1996 | Tipold, A., Pfister, H., Jungi, T.W. : |
| IgA-deficiency in the dog [German] Praktische Tierarzt 77:181 ff., 1996. | |
| 1992 | Mansfield, L.S., Schad, G.A. : |
| Strongyloides-stercoralis Infection in IgA-Deficient Dogs American Journal of Tropical Medicine and Hygiene 47:830-836, 1992. Pubmed reference: 1471742. | |
| 1991 | Campbell, K.L., Neitzel, C., Zuckermann, F.A. : |
| Immunoglobulin-A Deficiency in the Dog Canine Practice 16:7-11, 1991. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 27 May 2016