In other species: dog , pig , taurine cattle , dzo

Categories: Reproductive system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 123885 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Inability to conceive. Has a wide variety of causes, some of which are at least partly genetic.

Molecular basis: Li et al. (2021) explored the impact of S100A8 on immune homeostasis in sheep oviduct epithelial cells (SOEC) as "Chronic inflammation can cause oviduct mucosal damage and immune dysfunction, leading to infertility, early pregnancy loss, ectopic pregnancy, tumors, and a decrease in reproductive capacities in female animals." Transcriptome analysis of differentially treated SOECs indicated S100A8 as a gene for further analysis in cultured cells: "The S100A8 gene was disrupted using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 method .... S100A8 knockdown caused an excessive immune response, indicating that S100A8 is beneficial for maintaining immune homeostasis in the oviduct mucosa." (This study uses genome editing (GMO)). (Edited by Hannah Edgell 28/08/2022)

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene: