In other species: turkey , Japanese quail

Categories: Behaviour / neurological phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: The main symptom is an apparent lack of control of the muscles of the neck of the chick, resulting in the inability to stand or eat normally

Species-specific symbol: lo

Inheritance: Knowlton (1929) provided evidence of autosomal recessive inheritance in Rhode Island Red chickens. Shiina and Kobayashi (2024) reported a sex linked mode of inheritance in Silkie Fowl chickens.

Mapping: Okumura et al. (2013) conducted a genome scan with 122 informative miccrosatellites on 88 Rhode Island Red chickens from several generations of families segregation for this disorder. Linkage analysis highlighted just one region near microsatellite MCW0332 on chromosome GGA12. Subsequent homozygosity mapping narrowed the region "to approximately 1.1 Mb, between GGA12_28 and GGA12_30", which contains at least 10 genes. Shiina and Kobayashi (2024): "Normal and congenital loco-affected Silkie Fowl chicks exhibited no differences in the frequencies of markers on chromosome 12 adjacent to the congenital loco locus reported in a previous study in Rhode Island Red chickens. ... Bulked segregant analyses using next-generation sequencing narrowed the causative region of congenital loco to approximately 3.3 Mb between bases 9,569,012 and 12,863,792 on chromosome Z."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Rhode Island Red (Chicken) (VBO_0000599), Silkie (Chicken) (VBO_0000619).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below