OMIA:001041-30538 : Ventricular septal defect in Vicugna pacos (alpaca)

In other species: chicken , turkey , dog , domestic cat , horse , pig , taurine cattle , goat , sheep , rabbit

Categories: Cardiovascular system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 614429 (trait) , 614431 (trait) , 614432 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A congenital heart defect characterised by persistent patency (open-ness) of the ventricular septum, permitting flow of blood directly between ventricles, bypassing the pulmonary circulation and resulting in various degrees of cyanosis (blue discolouration of the skin) due to oxygen deficiency. Clinical signs include systolic murmur and a palpable thrill on both sides of the chest, dyspnoea and poor tolerance of exercise.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:001041-30538: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2016 Stieger-Vanegas, S.M., Scollan, K.F., Meadows, L., Sisson, D., Schlipf, J., Riebold, T., Löhr, C.V. :
Cardiac-gated computed tomography angiography in three alpacas with complex congenital heart disease. J Vet Cardiol 18:88-98, 2016. Pubmed reference: 26803197. DOI: 10.1016/j.jvc.2015.09.005.

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  • Created by Frank Nicholas on 09 Nov 2016