In other species: domestic cat

Categories: Normal phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 243400 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 1997

Molecular basis: Trepanier et al. (1997) showed that all dogs, and other canids, lack both NAT1 and NAT2 genes, and hence compleley lack the enzyme cytosolic N-acetyltransferase (NAT).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Genetic testing: Since all dogs lack the two genes, there is no need for any genetic testing.