OMIA:001943-9940 : Fecundity, generic in Ovis aries (sheep) |
In other species: dog , pig , taurine cattle , indicine cattle (zebu) , goat , rabbit
Categories: Reproductive system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Species-specific description: Several genes (e.g. BMP15, BMPR1B and GDF9) and alleles have been identified to impact fecundity/litter size in sheep and are listed as separate entries in OMIA. Any reference related to fecundity that are not related to these known genes or alleles are listed here.
Markers: Kang et al. (2021) "hypothesized that the polymorphisms of KDM3B gene were associated with sheep reproduction traits. A 7-nt nucleotide sequence variant (rs1088697156) within KDM3Bgene was identified in a total of 888 individuals, including the Australian White (AUW) sheep and Lanzhou Fat-tailed (LFT) sheep. II (insertion/insertion) and ID (insertion/deletion) genotypes of 7-nt variant were detected, which were at Hardy-Weinberg equilibrium (HWE) in detected breeds. Association analysis illustrated the 7-nt variant was significantly associated with the littersize, duration of pregnancy, live lamb number, live lamb rate, stillbirth number, stillbirth rate of average and different parity (P<0.05) in AUW sheep. Moreover, ‘ID’ was the dominant genotype with excellent consistency in reproductive traits." Li et al. (2021) "explored potential polymorphisms of the sheep TSHR gene, and a 29 bp nucleotide sequence variant (rs1089565492) was identified in the AUW sheep. ... Association analysis results showed the 29 bp variant was significantly associated with the litter size of the AUW sheep (p < 0.05)." Ma et al. (2022) "sequenced all coding regions of the LEPR gene of Mongolia sheep, and nine novel variants of the LEPR gene were detected by direct sequencing. Among them, the synonymous c.240C > T and c.279C > T mutations were significantly associated with the litter sizes of Mongolia ewes (P < 0.05 and P < 0.01, respectively) and Ujimqin ewes (P < 0.05 and P < 0.01, respectively)."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001943-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Akhmet, N., Zhu, L., Song, J., Akhatayeva, Z., Zhang, Q., Su, P., Li, R., Pan, C., Lan, X. : |
| Exploring the sheep MAST4 gene variants and their associations with litter size. Animals (Basel) 14:591, 2024. Pubmed reference: 38396560. DOI: 10.3390/ani14040591. | |
| Cao, H., Wen, Y., Ma, H., Liu, W. : | |
| Validation and analysis of COIL, a gene associated with multiple lambing traits in sheep. Genes (Basel) 15:235, 2024. Pubmed reference: 38397224. DOI: 10.3390/genes15020235. | |
| Imran, F.S., Al-Thuwaini, T.M. : | |
| The novel C268A variant of BMP2 is linked to the reproductive performance of Awassi and Hamdani sheep. Mol Biol Rep 51:267, 2024. Pubmed reference: 38302768. DOI: 10.1007/s11033-024-09274-2. | |
| Li, J., Sun, L., Sun, J., Jiang, H. : | |
| Genome-wide association research on the reproductive traits of Qianhua Mutton Merino sheep. Anim Biosci , 2024. Pubmed reference: 38575125. DOI: 10.5713/ab.23.0365. | |
| Li, J., Gong, Y., Wang, X., He, X., He, X., Chu, M., Di, R. : | |
| Screening of litter-size-associated SNPs in NOX4, PDE11A and GHR genes of sheep. Animals (Basel) 14:767, 2024. Pubmed reference: 38473152. DOI: 10.3390/ani14050767. | |
| Liu, K., Liu, Y., Chu, M. : | |
| Detection of polymorphisms in six genes and their association analysis with litter size in sheep. Anim Biotechnol :2309954, 2024. Pubmed reference: 38294691. DOI: 10.1080/10495398.2024.2309954. | |
| Zhang, R., Liu, Y., Li, W., Wang, P., Liu, Z., Wen, Y., Chu, M., Wang, L. : | |
| A mutation in LPAR2 activates the miR-939-5p-LPAR2-PI3K/AKT axis to regulate the proliferation and apoptosis of granulosa cells in sheep. Theriogenology 219:S0093-691X(24)00068-2:1-10, 2024. Pubmed reference: 38368704. DOI: 10.1016/j.theriogenology.2024.02.010. | |
| Zhu, L., Akhmet, N., Bo, D., Pan, C., Wu, J., Lan, X. : | |
| Genetic variant of the sheep E2F8 gene and its associations with litter size. Anim Biotechnol 35:2337751, 2024. Pubmed reference: 38597900. DOI: 10.1080/10495398.2024.2337751. | |
| 2023 | Abuzahra, M., Wijayanti, D., Effendi, M.H., Mustofa, I., Lamid, M. : |
| Association of melatonin receptor 1 A with litter size in sheep: A review. F1000Res 12:900, 2023. Pubmed reference: 38322310. DOI: 10.12688/f1000research.134890.2. | |
| Al-Thuwaini, T.M., Albazi, W.J., Al-Shuhaib, M.B.S., Merzah, L.H., Mohammed, R.G., Rhadi, F.A., Abd Al-Hadi, A.B., Alkhammas, A.H. : | |
| A novel c.100C > G mutation in the FST gene and its relation with the reproductive traits of Awassi ewes. Bioinform Biol Insights 17:11779322231170988, 2023. Pubmed reference: 37153841. DOI: 10.1177/11779322231170988. | |
| Al-Thuwaini, T.M., Al-Shuhaib, M.B.S., Kadhem, A.F., Alkhammas, A.H. : | |
| A missense p.Q>R234 mutation in the osteopontin gene Is associated with the prolificacy of Iraqi Awassi ewes. Bioinform Biol Insights 17:11779322231172848, 2023. Pubmed reference: 37197213. DOI: 10.1177/11779322231172848. | |
| Alkhammas, A.H., Al-Thuwaini, T.M. : | |
| Association of birth type and LHX4 gene polymorphism with reproductive hormones, growth hormone, and prolactin in Awassi ewes. Mol Biol Rep , 2023. Pubmed reference: 36787052. DOI: 10.1007/s11033-023-08285-9. | |
| Alkhammas, A.H., Al-Thuwaini, T.M., Al-Shuhaib, M.B.S., Khazaal, N.M. : | |
| Association of novel C319T variant of PITX2 gene 3'UTR region with reproductive performance in Awassi sheep. Bioinform Biol Insights 17:11779322231179018, 2023. Pubmed reference: 37313032. DOI: 10.1177/11779322231179018. | |
| Gong, Y., Chen, Q., He, X., Wang, X., He, X., Wang, Y., Pan, Z., Chu, M., Di, R. : | |
| Association analyses between single nucleotide polymorphisms in ZFAT, FBN1, FAM184B genes and litter size of Xinggao mutton sheep. Animals (Basel) 13:3639, 2023. Pubmed reference: 38066991. DOI: 10.3390/ani13233639. | |
| Ji, X., Cao, Z., Hao, Q., He, M., Cang, M., Yu, H., Ma, Q., Li, X., Bao, S., Wang, J., Tong, B. : | |
| Effects of new mutations in BMPRIB, GDF9, BMP15, LEPR, and B4GALNT2 genes on litter size in sheep. Vet Sci 10:258, 2023. Pubmed reference: 37104413. DOI: 10.3390/vetsci10040258. | |
| Liu, Z., Fu, S., He, X., Dai, L., Liu, X. : | |
| Integrated multi-tissue transcriptome profiling characterizes the genetic basis and biomarkers affecting reproduction in sheep (Ovis aries). Genes (Basel) 14, 2023. Pubmed reference: 37895230. DOI: 10.3390/genes14101881. | |
| Xie, S., Isaacs, K., Becker, G., Murdoch, B.M. : | |
| A computational framework for improving genetic variants identification from 5,061 sheep sequencing data. J Anim Sci Biotechnol 14:127, 2023. Pubmed reference: 37779189. DOI: 10.1186/s40104-023-00923-3. | |
| Yang, F., Liu, Y., Wang, P., Wang, X., Chu, M., Wang, P. : | |
| Mutation of the ETS1 3'UTR interacts with miR-216a-3p to regulate granulosa cell apoptosis in sheep. Theriogenology 210:133-142, 2023. Pubmed reference: 37499371. DOI: 10.1016/j.theriogenology.2023.07.025. | |
| Yiğit, S., Kul, S., Aci, R., Keskin, A., Tuygun, T., Duman, E. : | |
| The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed. Mol Biol Res Commun 12:109-115, 2023. Pubmed reference: 37525665. DOI: 10.22099/mbrc.2023.47336.1827. | |
| Yue, L., Li, W., Pan, Y., Lan, X., Zhang, Q., Pan, C. : | |
| Polymorphism of GTF2A1 gene is associated with litter size in sheep. Theriogenology 208:194-200, 2023. Pubmed reference: 37393655. DOI: 10.1016/j.theriogenology.2023.06.004. | |
| 2022 | Ma, S., Ji, X., Cang, M., Wang, J., Yu, H., Liu, Y., Zhang, W., Wu, Y., Zhao, S., Cao, G., Tong, B. : |
| Association analysis between novel variants in LEPR gene and litter size in Mongolia and ujimqin sheep breeds. Theriogenology 183:79-89, 2022. Pubmed reference: 35228133. DOI: 10.1016/j.theriogenology.2022.02.014. | |
| 2021 | Kang, Y., Bi, Y., Tang, Q., Xu, H., Lan, X., Zhang, Q., Pan, C. : |
| KDM3B gene affects female reproduction traits. Anim Biotechnol :1-7, 2021. Pubmed reference: 34081570. DOI: 10.1080/10495398.2021.1929270. | |
| Li, M., Zhou, Q., Pan, Y., Lan, X., Zhang, Q., Pan, C., Mao, C. : | |
| Screen of small fragment mutations within the sheep thyroid stimulating hormone receptor gene associated with litter size. Anim Biotechnol :1-6, 2021. Pubmed reference: 34895066. DOI: 10.1080/10495398.2021.1992415. | |
| Salehian-Dehkordi, H., Xu, Y.X., Xu, S.S., Li, X., Luo, L.Y., Liu, Y.J., Wang, D.F., Cao, Y.H., Shen, M., Gao, L., Chen, Z.H., Glessner, J.T., Lenstra, J.A., Esmailizadeh, A., Li, M.H., Lv, F.H. : | |
| Genome-wide detection of copy number variations and their association with distinct phenotypes in the world's sheep. Front Genet 12:670582, 2021. Pubmed reference: 34093663. DOI: 10.3389/fgene.2021.670582. | |
| Tao, L., Wang, X., Zhong, Y., Liu, Q., Xia, Q., Chen, S., He, X., Di, R., Chu, M. : | |
| Combined approaches identify known and novel genes associated with sheep litter size and non-seasonal breeding. Anim Genet 52:857-867, 2021. Pubmed reference: 34494299. DOI: 10.1111/age.13138. | |
| 2019 | Dolebo, A.T., Khayatzadeh, N., Melesse, A., Wragg, D., Rekik, M., Haile, A., Rischkowsky, B., Rothschild, M.F., Mwacharo, J.M. : |
| Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries). Mamm Genome 30:339-352, 2019. Pubmed reference: 31758253. DOI: 10.1007/s00335-019-09820-5. | |
| He, X., Zhang, Z., Liu, Q., Chu, M. : | |
| Polymorphisms of the melatonin receptor 1A gene that affect the reproductive seasonality and litter size in Small Tail Han sheep. Reprod Domest Anim , 2019. Pubmed reference: 31355975. DOI: 10.1111/rda.13538. | |
| La, Y., Liu, Q., Zhang, L., Chu, M. : | |
| Single nucleotide polymorphisms in SLC5A1, CCNA1, and ABCC1 and the association with litter size in small-tail Han sheep. Animals (Basel) 9, 2019. Pubmed reference: 31323962. DOI: 10.3390/ani9070432. | |
| Ma, H., Fang, C., Liu, L., Wang, Q., Aniwashi, J., Sulaiman, Y., Abudilaheman, K., Liu, W. : | |
| Identification of novel genes associated with litter size of indigenous sheep population in Xinjiang, China using specific-locus amplified fragment sequencing technology. PeerJ 7:e8079, 2019. Pubmed reference: 31788357. DOI: 10.7717/peerj.8079. | |
| 2005 | Bi, XD., Chu, MX., Jin, HG., Fang, L., Ye, SC. : |
| [Estrogen receptor as a candidate gene for prolificacy of small tail Han sheep] Yi Chuan Xue Bao 32:1060-5, 2005. Pubmed reference: 16252701. |
Edit History
- Created by Frank Nicholas on 19 Jun 2020
- Changed by Imke Tammen2 on 16 Jun 2021
- Changed by Imke Tammen2 on 17 Jun 2021
- Changed by Imke Tammen2 on 30 Jan 2022
- Changed by Imke Tammen2 on 29 Apr 2023
- Changed by Imke Tammen2 on 09 May 2023
- Changed by Imke Tammen2 on 19 Jul 2023