OMIA:000683-8932 : Muscular hypertrophy (double muscling) in Columba livia (rock pigeon) |
In other species: chicken , dog , pig , taurine cattle , goat , sheep , rabbit , water buffalo , Japanese quail , yellow catfish
Categories: Muscle phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 601788 (gene) , 614160 (trait)
Links to MONDO diseases:
Mendelian trait/disorder: unknown
Considered a defect: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Mapping: Hou et al. (2023): "The phenotypic data of body weight (BW) and body size (BS) of 556 meat pigeons at 52 and 80 weeks of age were collected. In total, 160 434 high-quality single nucleotide polymorphism sites were obtained by restriction site-associated DNA sequencing. The GWAS analysis revealed that MSTN, IGF2BP3 and NCAPG/LCORL were important candidate genes affecting the growth traits of meat pigeons. ... Phenotypic association validation with the use of two meat pigeon populations found that the MSTN mutation c.C861T [p.(T287T)] determines the MM [muscle mass]."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MSTN | myostatin | Columba livia | NW_004973256.1 (11434806..11440487) | MSTN | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000683-8932: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Hou, H., Wang, X., Li, X., Cai, X., Tu, Y., Yang, C., Yao, J. : |
| Genome-wide association study of growth traits and validation of key mutations (MSTN c.C861T) associated with the muscle mass of meat pigeons. Anim Genet 55:110-122, 2024. Pubmed reference: 38069460. DOI: 10.1111/age.13382. | |
| 2019 | Liu, H.H., Mao, H.G., Dong, X.Y., Cao, H.Y., Liu, K., Yin, Z.Z. : |
| Expression of MSTN gene and its correlation with pectoralis muscle fiber traits in the domestic pigeons (Columba livia). Poult Sci 98:5265-5271, 2019. Pubmed reference: 31265735. DOI: 10.3382/ps/pez399. | |
| 2013 | Dybus, A., Proskura, W.S., Sadkowski, S., Pawlina, E. : |
| A single nucleotide polymorphism in exon 3 of the myostatin gene in different breeds of domestic pigeon (Columba livia var. domestica). Veterinarni Medicina 58:32–38, 2013. |
Edit History
- Created by Imke Tammen2 on 17 Jan 2024
- Changed by Imke Tammen2 on 17 Jan 2024