OMIA 001323-9823 : Dwarfism, Laron in Sus scrofa

See the equivalent entry at NCBI

In other species: cattle

Possible human homologue (MIM number): 262500

Mendelian trait/disorder: yes

Considered a defect: yes

Key mutation known: no

Species-specific description: Genetically-modifed organism; GMO

Molecular basis: Cui et al. (2015) created a GMO miniature pig model of Laron disease by knocking out the GHR gene via zinc finger nucleas (ZFN technology.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GHR growth hormone receptor Sus scrofa 16 NC_010458.4 (27126300..27422618) GHR Homologene, Ensembl, NCBI gene

Reference


2015 Cui, D., Li, F., Li, Q., Li, J., Zhao, Y., Hu, X., Zhang, R., Li, N. :
Generation of a miniature pig disease model for human Laron syndrome. Sci Rep 5:15603, 2015. Pubmed reference: 26511035. DOI: 10.1038/srep15603.

Edit History


  • Created by Frank Nicholas on 29 Sep 2016
  • Changed by Frank Nicholas on 29 Sep 2016