In other species: ass (donkey) , horse

Categories: Pigmentation phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 601621 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Molecular basis: Musiał et al. (2023) investigated the presence of two equine TBX3 variants (see OMIA:001972-9796 : Coat colour, dun in Equus caballus) and a MC1R variant associated with 'fox' colour in 23 Przewalski horses: "The coat color genes analyses indicated only native, wild genotypes. ... The results assigned all horses to the [TBX3] genotype with G/G alleles in both SNP loci, and deletions were not observed. ... none of Przewalski horses presented C to T missense mutation associated with an unfavorable [MC1R] ‘fox’ color variant for this species."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing