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OMIA:002752-8090 : Cardiac defects, MYRF-related in Oryzias latipes (Japanese medaka)

Categories: Cardiovascular system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 618280 (trait) , 608329 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
myrfl myelin regulatory factor-like Oryzias latipes 23 NC_019881.1 (24122469..24126976) myrfl Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002752-8090: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 Doering, L., Cornean, A., Thumberger, T., Benjaminsen, J., Wittbrodt, B., Kellner, T., Hammouda, O.T., Gorenflo, M., Wittbrodt, J., Gierten, J. :
CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease. Dis Model Mech 16:dmm049811, 2023. Pubmed reference: 37584388. DOI: 10.1242/dmm.049811.

Edit History


  • Created by Imke Tammen2 on 18 Aug 2023
  • Changed by Imke Tammen2 on 18 Aug 2023
  • Changed by Imke Tammen2 on 18 Dec 2023