In other species: dog , domestic cat , goat

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Lissencephalic brains (brains with a smooth cerebral cortex) are normal in many species (including some small rodents and small primates). The disease lissencephaly refers to a group of brain conditions in species that normally have gyrencephalic brains, in which the cerebral cortex is smooth due to defective neuronal migration during embryonic development resulting in a reduction or absence of sulci and gyri. Various non-genetic and genetic factors have been reported to cause lissencephaly.

Species-specific description: Some references listed here were previously listed under OMIA:001867

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing