OMIA:002795-9940 : Claw/hoof colour in Ovis aries (sheep) |
Categories: Pigmentation phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 156845 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Mapping: Su et al. (2023) "conducted a genome-wide association study (GWAS) analysis using restriction site associated DNA sequencing (RAD-seq) data from 577 Australian White sheep (black hoof color = 283, grey hoof color = 106, amber hoof color = 186) and performed association analysis utilizing the mixed linear model in EMMAX. The results of GWAS demonstrated that a specific single-nucleotide polymorphism (SNP; g. 33097911G>A) in intron 14 of the microphthalmia-associated transcription factor (MITF) gene was significantly associated with the hoof color in AUW sheep (p = 9.40 × 10−36)."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MITF | microphthalmia-associated transcription factor | Ovis aries | 19 | NC_056072.1 (31911158..31673697) | MITF | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002795-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2023 | Su, P., Wu, H., Huang, Y., Lu, X., Yin, J., Zhang, Q., Lan, X. : |
| The hoof color of Australian White sheep is associated with genetic variation of the MITF gene. Animals (Basel) 13, 2023. Pubmed reference: 37893942. DOI: 10.3390/ani13203218. |
Edit History
- Created by Imke Tammen2 on 05 Nov 2023
- Changed by Imke Tammen2 on 05 Nov 2023