OMIA:002817-516951 : Skin colour, TYRP1-related in Phrynocephalus putjatai (toad-headed agama) |
Categories: Pigmentation phene , Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 115501 (gene) , 612271 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Molecular basis: Sun et al. (2024) " studied adjacent populations of the species of toad-headed agama, Phrynocephalus putjatai, distributed in two distinct habitats on Qinghai-Tibet Plateau (QTP) - alpine meadows and sand dunes - with two distinct phenotypes (dark vs. light) in dorsal coloration. ... by genome resequencing analysis, we detected a novel mutation in Tyrp1 that underpinned this color adaptation. The allele frequencies at the site of SNP 459# in the gene of Tyrp1 are 22.22% G/C and 77.78% C/C in dark lizards and 100% G/G in light lizards."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TYRP1 | Phrynocephalus putjatai | - | no genomic information (-..-) | TYRP1 | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002817-516951: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2024 | Sun, B.J., Li, W.M., Lv, P., Wen, G.N., Wu, D.Y., Tao, S.A., Liao, M.L., Yu, C.Q., Jiang, Z.W., Wang, Y., Xie, H.X., Wang, X.F., Chen, Z.Q., Liu, F., Du, W.G. : |
| Genetically encoded lizard color divergence for camouflage and thermoregulation. Mol Biol Evol :msae009, 2024. Pubmed reference: 38243850. DOI: 10.1093/molbev/msae009. |
Edit History
- Created by Imke Tammen2 on 22 Jan 2024
- Changed by Imke Tammen2 on 22 Jan 2024