In other species: turkey , pig , taurine cattle , goat

Categories: Haematopoietic system phene

Single-gene trait/disorder: yes

Disease-related: no

Key variant known: no

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars.

Mapping: Fulton et al. (2025): "Multiple unrelated genetic resources for which both DNA and serologically defined L alloantigen information were utilized ... . Genomic information was obtained from 600 K or 54 K SNP arrays, or low pass sequence information and utilized in GWAS to identify a candidate region. A strong GWAS peak was identified on chromosome 4 between 29.8 and 32 Mbp from multiple sample sets."

Molecular basis: Fulton et al. (2025) identified ABCE1 as likely candidate gene: "The specific mechanism by which the ABCE1 gene product in chickens impacts a serological determinant detected by hemagglutination remains unknown."

Associated gene: