OMIA:001470-9615 : Necrotising meningoencephalitis in Canis lupus familiaris (dog) |
Categories: Nervous system phene
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: yes
Key variant known: no
Cross-species summary: Necrotizing/necrotising meningoencephalitis is one of several non-infectious inflammatory disorders of the central nervous system (CNS) without a histopathological diagnosis (meningoencephalitis of unknown etiology (MUE))
Species-specific name: includes Pug dog myelopathy (PDM), Pug dog encephalitis (PDE)
Species-specific symbol: NME
Mapping: By conducting a GWAS on 28 affected and 66 control Pugs, each genotyped with the Illumina CanineHD Genotyping BeadChip (yielding 86,692 informative SNPs for analysis), Barber et al. (2011) highlighted two regions, one being the DLA class-II region of the MHC on chromosome CFA12, and the other being within the STYX gene on CFA8. Windsor et al. (2022) summarised findings from other studies: "Genetic risk for NME has been linked to chromosome 12 within the dog leukocyte antigen (DLA) major histocompatibility (MHC) II complex [Greer et al., 2009; Pedersen et al., 2022; Safra et al., 2011] with additional association to chromosome 15 in the pug and chromosome 4 in the maltese [Schrauwen et al., 2014].
Markers: van Renen et al. (2024) investigated the previously identified NME risk variant CFA12:2605517delC in European pugs and concluded that the "CFA12:2605517delC genetic risk variant is widely distributed in the European pug population and frequently homozygous in pugs with a NME phenotype. The data support the clinical relevance of the CFA12:2605517delC genetic risk variant."
Breeds:
Brussels Griffon (Dog) (VBO_0200241),
Chihuahua (Dog) (VBO_0200338),
Coton de Tulear (Dog) (VBO_0200389),
Maltese (Dog) (VBO_0200856),
Papillon (Dog) (VBO_0200985),
Pekingese (Dog) (VBO_0200994),
Pug (Dog) (VBO_0201089),
Shih Tzu (Dog) (VBO_0201223),
Yorkshire Terrier (Dog) (VBO_0201448).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001470-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Rohdin, C., Ljungvall, I., Jäderlund, K.H., Svensson, A., Lindblad-Toh, K., Häggström, J. : |
| Assessment of glial fibrillary acidic protein and anti-glial fibrillary acidic protein autoantibody concentrations and necrotising meningoencephalitis risk genotype in dogs with pug dog myelopathy. Vet Rec 194:e3895, 2024. Pubmed reference: 38704817. DOI: 10.1002/vetr.3895. | |
| van Renen, J., Kehl, A., Buhmann, G., Matiasek, L.A., Zablotski, Y., Fischer, A. : | |
| Allele frequency of a genetic risk variant for necrotizing meningoencephalitis in pug dogs from Europe and association with the clinical phenotype. Front Vet Sci 11:1407288, 2024. Pubmed reference: 38840637. DOI: 10.3389/fvets.2024.1407288. | |
| Windsor, R., Stewart, S., Huentelman, M., Keller, S., Khanna, C. : | |
| An early clinical phenotype of necrotizing meningoencephalitis in the Pug reveals similarities to multiple sclerosis in humans. Am J Vet Res 85:ajvr.23.07.0164, 2024. Pubmed reference: 37913632. DOI: 10.2460/ajvr.23.07.0164. | |
| 2023 | Son, M., Chae, Y., Kim, S., Yun, T., Koo, Y., Lee, D., Kim, H., Yang, M.P., Kang, B.T., Kim, S. : |
| Abnormal hyperphosphorylation of Tau in canine immune-mediated meningoencephalitis. In Vivo 37:1065-1076, 2023. Pubmed reference: 37103078. DOI: 10.21873/invivo.13181. | |
| 2022 | Windsor, R., Stewart, S., Schmidt, J., Mosqueda, M., Piras, I., Keller, S.M., Steinmetz, B., Borjesson, D.L., Huentelman, M., Khanna, C. : |
| A potential early clinical phenotype of necrotizing meningoencephalitis in genetically at-risk pug dogs. J Vet Intern Med 36:1382-1389, 2022. Pubmed reference: 35621070. DOI: 10.1111/jvim.16444. | |
| 2014 | Cooper, J.J., Schatzberg, S.J., Vernau, K.M., Summers, B.A., Porter, B.F., Siso, S., Young, B.D., Levine, J.M. : |
| Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review. J Vet Intern Med 28:198-203, 2014. Pubmed reference: 24428322. DOI: 10.1111/jvim.12233. | |
| Schrauwen, I., Barber, R.M., Schatzberg, S.J., Siniard, A.L., Corneveaux, J.J., Porter, B.F., Vernau, K.M., Keesler, R.I., Matiasek, K., Flegel, T., Miller, A.D., Southard, T., Mariani, C.L., Johnson, G.C., Huentelman, M.J. : | |
| Identification of novel genetic risk loci in Maltese dogs with necrotizing meningoencephalitis and evidence of a shared genetic risk across toy dog breeds. PLoS One 9:e112755, 2014. Pubmed reference: 25393235. DOI: 10.1371/journal.pone.0112755. | |
| 2011 | Barber, R.M., Schatzberg, S.J., Corneveaux, J.J., Allen, A.N., Porter, B.F., Pruzin, J.J., Platt, S.R., Kent, M., Huentelman, M.J. : |
| Identification of risk Loci for necrotizing meningoencephalitis in pug dogs. J Hered 102 Suppl 1:S40-6, 2011. Pubmed reference: 21846746. DOI: 10.1093/jhered/esr048. | |
| Pedersen, N., Liu, H., Millon, L., Greer, K. : | |
| Dog leukocyte antigen class II-associated genetic risk testing for immune disorders of dogs: simplified approaches using Pug dog necrotizing meningoencephalitis as a model. J Vet Diagn Invest 23:68-76, 2011. Pubmed reference: 21217030. | |
| Safra, N., Pedersen, N.C., Wolf, Z., Johnson, E.G., Liu, H.W., Hughes, A.M., Young, A., Bannasch, D.L. : | |
| Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations. Vet J 189:220-6, 2011. Pubmed reference: 21741283. DOI: 10.1016/j.tvjl.2011.06.023. | |
| 2010 | Greer, KA., Wong, AK., Liu, H., Famula, TR., Pedersen, NC., Ruhe, A., Wallace, M., Neff, MW. : |
| Necrotizing meningoencephalitis of Pug dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens 76:110-8, 2010. Pubmed reference: 20403140. DOI: 10.1111/j.1399-0039.2010.01484.x. | |
| 2009 | Greer, KA., Schatzberg, SJ., Porter, BF., Jones, KA., Famula, TR., Murphy, KE. : |
| Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug. Res Vet Sci 86:438-42, 2009. Pubmed reference: 19014875. DOI: 10.1016/j.rvsc.2008.10.002. | |
| Young, BD., Levine, JM., Fosgate, GT., de Lahunta, A., Flegel, T., Matiasek, K., Miller, A., Silver, G., Sharp, N., Greer, K., Schatzberg, SJ. : | |
| Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in Pug dogs. J Vet Intern Med 23:527-35, 2009. Pubmed reference: 19645838. DOI: 10.1111/j.1939-1676.2009.0306.x. | |
| 2008 | Eom, KD., Lim, CY., Gu, SH., Kang, BT., Kim, YB., Jang, DP., Woo, EJ., Kim, D., Cho, ZH., Park, HM. : |
| Positron emission tomography features of canine necrotizing meningoencephalitis. Vet Radiol Ultrasound 49:595-9, 2008. Pubmed reference: 19051653. | |
| Flegel, T., Henke, D., Boettcher, I.C., Aupperle, H., Oechtering, G., Matiasek, K. : | |
| Magnetic resonance imaging findings in histologically confirmed Pug dog encephalitis. Vet Radiol Ultrasound 49:419-24, 2008. Pubmed reference: 18833947. DOI: 10.1111/j.1740-8261.2008.00400.x. | |
| Higgins, RJ., Dickinson, PJ., Kube, SA., Moore, PF., Couto, SS., Vernau, KM., Sturges, BK., LeCouteur, RA. : | |
| Necrotizing meningoencephalitis in five Chihuahua dogs. Vet Pathol 45:336-46, 2008. Pubmed reference: 18487490. DOI: 10.1354/vp.45-3-336. | |
| Levine, JM., Fosgate, GT., Porter, B., Schatzberg, SJ., Greer, K. : | |
| Epidemiology of necrotizing meningoencephalitis in Pug dogs. J Vet Intern Med 22:961-8, 2008. Pubmed reference: 18647157. DOI: 10.1111/j.1939-1676.2008.0137.x. | |
| 2004 | Fearnside, SM., Kessell, AE., Powe, JR. : |
| Cervical hyperaesthesia in a Maltese Terrier with necrotising meningoencephalitis. Aust Vet J 82:550-2, 2004. Pubmed reference: 15478726. | |
| 2001 | Cantile, C., Chianini, F., Arispici, M., Fatzer, R. : |
| Necrotizing meningoencephalitis associated with cortical hippocampal hamartia in a Pekingese dog. Vet Pathol 38:119-22, 2001. Pubmed reference: 11199160. DOI: 10.1354/vp.38-1-119. | |
| 1999 | Ducoté, J.M., Johnson, K.E., Dewey, C.W., Walker, M.A., Coates, J.R., Berridge, B.R. : |
| Computed tomography of necrotizing meningoencephalitis in 3 Yorkshire Terriers. Vet Radiol Ultrasound 40:617-21, 1999. Pubmed reference: 10608689. | |
| Uchida, K., Hasegawa, T., Ikeda, M., Yamaguchi, R., Tateyama, S. : | |
| Detection of an autoantibody from Pug dogs with necrotizing encephalitis (Pug dog encephalitis). Vet Pathol 36:301-7, 1999. Pubmed reference: 10421096. DOI: 10.1354/vp.36-4-301. | |
| 1995 | Stalis, IH., Chadwick, B., Dayrell-Hart, B., Summers, BA., Van Winkle, TJ. : |
| Necrotizing meningoencephalitis of Maltese dogs. Vet Pathol 32:230-5, 1995. Pubmed reference: 7604489. | |
| 1994 | Kobayashi, Y., Ochiai, K., Umemura, T., Goto, N., Ishida, T., Itakura, C. : |
| Necrotizing meningoencephalitis in pug dogs in Japan. J Comp Pathol 110:129-36, 1994. Pubmed reference: 8040380. | |
| 1989 | Cordy, DR., Holliday, TA. : |
| A necrotizing meningoencephalitis of pug dogs. Vet Pathol 26:191-4, 1989. Pubmed reference: 2763409. |
Edit History
- Created by Frank Nicholas on 03 Jul 2009
- Changed by Frank Nicholas on 22 May 2013
- Changed by Imke Tammen2 on 23 Oct 2022
- Changed by Imke Tammen2 on 16 Nov 2022
- Changed by Imke Tammen2 on 29 Apr 2023
- Changed by Imke Tammen2 on 07 May 2024
- Changed by Imke Tammen2 on 27 Jul 2024