Categories: Mortality / aging (incl. embryonic lethal)

Possible human homologues (MIM numbers): 258900 (trait) , 613891 (gene)

Links to relevant human diseases in MONDO:

• MONDO:0009797: orotic aciduria

Cross-species summary: Uridine monophosphate synthase (UMPS) is the enzyme responsible for converting orotic acid to uridine monophosphate (UMP), which is an essential component of pyrimidine nucleotides. This enzyme actually has two enzymatic functions: orotic phosphoribosyltransferase (OPRTase) and orotidine monophosphate decarboxylase (OMPDCase), corresponding to the last two steps in pyrimidine synthesis. Since pyrimidines are vital ingredients of nucleic acids, it follows that a deficiency of UMPS can have quite severe consequences.

Species in which this phene is found:
taurine cattle (Bos taurus)
water buffalo (Bubalus bubalis)