OMIA 000269-9615 : Dermatitis, atopic in Canis lupus familiaris

In other species: domestic cat

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 603165 , 605803 , 605804 , 605805 , 605844 , 605845 , 613064 , 613518 , 613519

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: Canine atopic dermatitis (CAD)

Inheritance: Shaw et al. (2004) estimated the heritability of CAD (as a binary trait) to be 0.47 in Golden and Labrador Retrievers.

Mapping: The first GWAS to be conducted on this disorder was by Wood et al. (2009), who genotyped each of 25 affected and 23 control Labrador Retrievers with the Illumina Canine SNP20 chip (yielding 22,133 SNPs for analysis). Validation across 8 breeds confirmed the GWAS results which highlighted regions on chromosomes CFA10 and 29, and less-significant regions on a range of other chromosomes.

From a linkage analysis of data obtained from a genome scan with 256 microsatellites on 108 West Highland White Terriers, Salzmann et al. (2011) were not able to identify any chromosomal region linked to CAD.

A GWAS conducted by Roque et al. (2012) on data from 35 CAD and 25 control West Highland White Terriers, each genotyped with the Affymetrix Canine SNP V2 (yielding around 42,800 SNPs) highlighted a 1.3Mb region on chromosome CFA17. Of the 19 genes in or near this region, one (PTPN22) was of particular interest: "Four haplotypes within this locus were differently distributed between cases and controls in this population of dogs".

Tengvall et al. (2013) conducted a GWAS on 91 carefully-defined CAD cases and 88 CAD controls from the Swedish population of German Shepherd dogs, each genotyped with the Illumina 170K CanineHD BeadChip, and allowing for the all-important effect of IgA level. A 1.5Mb region on chromosome CFA27 was highlighted. Subsequent fine-mapping/resequencing reduced this candidate region to a 209kb region containing just one gene, namely the "PKP2 gene, encoding Plakophilin 2 expressed in the desmosomes and important for skin structure".

Clinical features: Clinical and other issues relating to this disorder were comprehensively covered in an extensive series of papers published in Veterinary Immunology and Immunopathology in 2001 (all included in the references below) by the ACVD task force on canine atopic dermatitis.

Prevalence: From an anlysis of "Case records (n = 23,000) from [the] University [of Sydney] Veterinary Teaching Hospital (UVTH) dogs, including 722 with CAD" compared with 13 previous studies, Mazrier et al. (2016) reported that "Eleven dog breeds with significant increased OR (≥1.0) were identified; all with breed CAD cases proportionally higher than their base hospital population. Gender risk in males from the pug dog breed (P = 0.007) was detected and the bichon frise breed had a similar trend (P = 0.05). Sixteen predisposed dog breeds were identified by systematic review. All breeds with significant increased OR in UVTH had ADRPR > 1.4; five (boxer, bulldog, Labrador retriever, pug, West Highland white terrier) were recognized as predisposed worldwide. One clade of breeds with common ancestry was highly represented in CAD cases worldwide and in Australia (81% of the significant OR cases)."

Breeds: Boxer, Bulldog, German Shepherd Dog, Labrador Retriever, Pug, West Highland White terrier.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Martel, B.C., Lovato, P., Bäumer, W., Olivry, T. :
Translational Animal Models of Atopic Dermatitis for Preclinical Studies. Yale J Biol Med 90:389-402, 2017. Pubmed reference: 28955179.
2016 Asahina, R., Maeda, S. :
A review of the roles of keratinocyte-derived cytokines and chemokines in the pathogenesis of atopic dermatitis in humans and dogs. Vet Dermatol :, 2016. Pubmed reference: 27426268. DOI: 10.1111/vde.12351.
Bruet, V., Dumon, H., Bourdeau, P., Desfontis, J.C., Martin, L. :
Prospective pilot study to detect dogs with non food-induced canine atopic dermatitis using Fourier transform infrared spectroscopy. Vet Dermatol 27:356-e89, 2016. Pubmed reference: 27500559. DOI: 10.1111/vde.12365.
Fujimura, M., Ishimaru, H. :
Rush sublingual immunotherapy in canine atopic dermatitis: a prospective pilot study. Pol J Vet Sci 19:3-6, 2016. Pubmed reference: 27096781. DOI: 10.1515/pjvs-2016-0001.
Hauck, V., Hügli, P., Meli, M.L., Rostaher, A., Fischer, N., Hofmann-Lehmann, R., Favrot, C. :
Increased numbers of FoxP3-expressing CD4+ CD25+ regulatory T cells in peripheral blood from dogs with atopic dermatitis and its correlation with disease severity. Vet Dermatol 27:26-e9, 2016. Pubmed reference: 26748886. DOI: 10.1111/vde.12279.
Kim, H.J., Cronin, M., Ahrens, K., Papastavros, V., Santoro, D., Marsella, R. :
A comparative study of epidermal tight junction proteins in a dog model of atopic dermatitis. Vet Dermatol 27:40-e11, 2016. Pubmed reference: 26663564. DOI: 10.1111/vde.12276.
Majewska, A., Gajewska, M., Dembele, K., Maciejewski, H., Prostek, A., Jank, M. :
Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis. BMC Vet Res 12:174, 2016. Pubmed reference: 27553600. DOI: 10.1186/s12917-016-0805-6.
Mazrier, H., Vogelnest, L.J., Thomson, P.C., Taylor, R.M., Williamson, P. :
Canine atopic dermatitis: breed risk in Australia and evidence for a susceptible clade. Vet Dermatol 27:167-e42, 2016. Pubmed reference: 27188769. DOI: 10.1111/vde.12317.
Pierezan, F., Olivry, T., Paps, J.S., Lawhon, S.D., Wu, J., Steiner, J.M., Suchodolski, J.S., Rodrigues Hoffmann, A. :
The skin microbiome in allergen-induced canine atopic dermatitis. Vet Dermatol :, 2016. Pubmed reference: 27485242. DOI: 10.1111/vde.12366.
Sakamoto, M., Asahina, R., Kamishina, H., Maeda, S. :
Transcription of thymic stromal lymphopoietin via Toll-like receptor 2 in canine keratinocytes: a possible association of Staphylococcus spp. in the deterioration of allergic inflammation in canine atopic dermatitis. Vet Dermatol :, 2016. Pubmed reference: 27018172. DOI: 10.1111/vde.12301.
Saridomichelakis, M.N., Olivry, T. :
An update on the treatment of canine atopic dermatitis. Vet J 207:29-37, 2016. Pubmed reference: 26586215. DOI: 10.1016/j.tvjl.2015.09.016.
Tengvall, K., Kozyrev, S., Kierczak, M., Bergvall, K., Farias, F.H., Ardesjö-Lundgren, B., Olsson, M., Murén, E., Hagman, R., Leeb, T., Pielberg, G., Hedhammar, Å., Andersson, G., Lindblad-Toh, K. :
Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs. BMC Genet 17:97, 2016. Pubmed reference: 27357287. DOI: 10.1186/s12863-016-0404-3.
2015 Bizikova, P., Pucheu-Haston, C.M., Eisenschenk, M.N., Marsella, R., Nuttall, T., Santoro, D. :
Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis. Vet Dermatol :, 2015. Pubmed reference: 25703290. DOI: 10.1111/vde.12198.
Bizikova, P., Santoro, D., Marsella, R., Nuttall, T., Eisenschenk, M.N., Pucheu-Haston, C.M. :
Review: Clinical and histological manifestations of canine atopic dermatitis. Vet Dermatol :, 2015. Pubmed reference: 25676252. DOI: 10.1111/vde.12196.
Hensel, P., Santoro, D., Favrot, C., Hill, P., Griffin, C. :
Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification. BMC Vet Res 11:196, 2015. Pubmed reference: 26260508. DOI: 10.1186/s12917-015-0515-5.
Le Roy, L., Le Poder, S., Desquilbet, L., Perrot, S., Cavana, P., Marignac, G. :
Canine Atopic Dermatitis Diagnostic Criteria: Evaluation of Four Sets of Published Criteria among Veterinary Students. J Vet Med Educ 42:79-84, 2015. Pubmed reference: 25588943. DOI: 10.3138/jvme.0414-038R1.
Mineshige, T., Kamiie, J., Sugahara, G., Yasuno, K., Aihara, N., Kawarai, S., Yamagishi, K., Shirota, M., Shirota, K. :
Expression of Periostin in Normal, Atopic, and Nonatopic Chronically Inflamed Canine Skin. Vet Pathol :, 2015. Pubmed reference: 25755133. DOI: 10.1177/0300985815574007.
Müller, M.R., Linek, M., Löwenstein, C., Röthig, A., Doucette, K., Thorstensen, K., Mueller, R.S. :
Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis. Vet J :, 2015. Pubmed reference: 26975448. DOI: 10.1016/j.tvjl.2015.11.012.
Pucheu-Haston, C.M., Bizikova, P., Eisenschenk, M.N., Santoro, D., Nuttall, T., Marsella, R. :
Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis. Vet Dermatol :, 2015. Pubmed reference: 25728611. DOI: 10.1111/vde.12201.
Pucheu-Haston, C.M., Bizikova, P., Marsella, R., Santoro, D., Nuttall, T., Eisenschenk, M.N. :
Review: Lymphocytes, cytokines, chemokines and the T-helper 1-T-helper 2 balance in canine atopic dermatitis. Vet Dermatol 26:124-e32, 2015. Pubmed reference: 25808535. DOI: 10.1111/vde.12205.
Pucheu-Haston, C.M., Eisenschenk, M.N., Bizikova, P., Marsella, R., Nuttall, T., Santoro, D. :
Introduction to the review articles by ICADA on the pathogenesis of atopic dermatitis in dogs. Vet Dermatol 26:77-8, 2015. Pubmed reference: 25808534. DOI: 10.1111/vde.12207.
Pucheu-Haston, C.M., Santoro, D., Bizikova, P., Eisenschenk, M.N., Marsella, R., Nuttall, T. :
Review: Innate immunity, lipid metabolism and nutrition in canine atopic dermatitis. Vet Dermatol :, 2015. Pubmed reference: 25728538. DOI: 10.1111/vde.12199.
Santoro, D., Marsella, R., Pucheu-Haston, C.M., Eisenschenk, M.N., Nuttall, T., Bizikova, P. :
Review: Pathogenesis of canine atopic dermatitis: skin barrier and host-micro-organism interaction. Vet Dermatol :, 2015. Pubmed reference: 25683702. DOI: 10.1111/vde.12197.
2014 Bruet, V., Lieubeau, B., Herve, J., Roussel, A., Imparato, L., Desfontis, J., Bourdeau, P. :
Increased numbers of peripheral blood CD34+ cells in dogs with canine atopic dermatitis. Vet Dermatol :, 2014. Pubmed reference: 25537867. DOI: 10.1111/vde.12191.
Litzlbauer, P., Weber, K., Mueller, R.S. :
Oral and subcutaneous therapy of canine atopic dermatitis with recombinant feline interferon omega. Cytokine 66:54-9, 2014. Pubmed reference: 24548425. DOI: 10.1016/j.cyto.2013.12.001.
Olivry, T., Saridomichelakis, M., Nuttall, T., Bensignor, E., Griffin, C.E., Hill, P.B. :
Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol :, 2014. Pubmed reference: 24461108. DOI: 10.1111/vde.12107.
Schumann, J., Basiouni, S., Gück, T., Fuhrmann, H. :
Treating canine atopic dermatitis with unsaturated fatty acids: the role of mast cells and potential mechanisms of action. J Anim Physiol Anim Nutr (Berl) :, 2014. Pubmed reference: 24628699. DOI: 10.1111/jpn.12181.
2013 Dip, R., Carmichael, J., Letellier, I., Strehlau, G., Roberts, E., Bensignor, E., Rosenkrantz, W. :
Concurrent short-term use of prednisolone with cyclosporine A accelerates pruritus reduction and improvement in clinical scoring in dogs with atopic dermatitis. BMC Vet Res 9:173, 2013. Pubmed reference: 24004561. DOI: 10.1186/1746-6148-9-173.
Fernández-Caldas, E. :
On mite allergy in dogs and humans. Int Arch Allergy Immunol 160:329-30, 2013. Pubmed reference: 23172128. DOI: 10.1159/000343492.
Jassies-van der Lee, A., Rutten, V., Spiering, R., van Kooten, P., Willemse, T., Broere, F. :
The immunostimulatory effect of CpG oligodeoxynucleotides on peripheral blood mononuclear cells of healthy dogs and dogs with atopic dermatitis. Vet J :, 2013. Pubmed reference: 24461202. DOI: 10.1016/j.tvjl.2013.12.016.
Jung, J.Y., Nam, E.H., Park, S.H., Han, S.H., Hwang, C.Y. :
Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis. J Vet Sci 14:199-205, 2013. Pubmed reference: 23814473. DOI: 10.4142/jvs.2013.14.2.199.
Koike, A., Kano, R., Nagata, M., Chen, C., Hwang, C.Y., Hasegawa, A., Kamata, H. :
Genotyping of Malassezia pachydermatis Isolates from Canine Healthy Skin and Lesional Skin of Atopic Dermatitis in Japan, Korea and Taiwan. J Vet Med Sci :, 2013. Pubmed reference: 23411408.
Lancto, C.A., Torres, S.M., Hendrickson, J.A., Martins, K.V., Rutherford, M.S. :
Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions. Vet Dermatol :, 2013. Pubmed reference: 23701024. DOI: 10.1111/vde.12034.
Nuttall, T. :
The genomics revolution: will canine atopic dermatitis be predictable and preventable? Vet Dermatol 24:10-8.e3-4, 2013. Pubmed reference: 23331674. DOI: 10.1111/j.1365-3164.2012.01094.x.
Nuttall, T., Uri, M., Halliwell, R. :
Canine atopic dermatitis - what have we learned? Vet Rec 172:201-7, 2013. Pubmed reference: 23436599. DOI: 10.1136/vr.f1134.
Ognjenovic, J., Milcic-Matic, N., Smiljanic, K., Vuckovic, O., Burazer, L., Popovic, N., Stanic-Vucinic, D., Velickovic, T.C. :
Immunoproteomic characterization of Ambrosia artemisiifolia pollen allergens in canine atopic dermatitis. Vet Immunol Immunopathol 155:38-47, 2013. Pubmed reference: 23830203. DOI: 10.1016/j.vetimm.2013.06.005.
Pellicoro, C., Marsella, R., Ahrens, K. :
Pilot study to evaluate the effect of topical dimethicone on clinical signs and skin barrier function in dogs with naturally occurring atopic dermatitis. Vet Med Int 2013:239186, 2013. Pubmed reference: 23710417. DOI: 10.1155/2013/239186.
Prélaud, A.R., Fuchs, S., Weber, K., Winter, G., Coester, C., Mueller, R.S. :
In vitro effects of CpG oligodeoxynucleotides delivered by gelatin nanoparticles on canine peripheral blood mononuclear cells of atopic and healthy dogs - a pilot study. Vet Dermatol :, 2013. Pubmed reference: 23826658. DOI: 10.1111/vde.12056.
Puigdemont, A., Brazís, P., Ordeix, L., Dalmau, A., Fuertes, E., Olivar, A., Pérez, C., Ravera, I. :
Efficacy of a new topical cyclosporine A formulation in the treatment of atopic dermatitis in dogs. Vet J :, 2013. Pubmed reference: 23562341. DOI: 10.1016/j.tvjl.2013.02.018.
Santoro, D., Marsella, R., Ahrens, K., Graves, T.K., Bunick, D. :
Altered mRNA and protein expression of filaggrin in the skin of a canine animal model for atopic dermatitis. Vet Dermatol 24:329-36, e73, 2013. Pubmed reference: 23668858. DOI: 10.1111/vde.12031.
Tengvall, K., Kierczak, M., Bergvall, K., Olsson, M., Frankowiack, M., Farias, F.H., Pielberg, G., Carlborg, O., Leeb, T., Andersson, G., Hammarström, L., Hedhammar, A., Lindblad-Toh, K. :
Correction: Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic Dermatitis. PLoS Genet 9:, 2013. Pubmed reference: 23696744. DOI: 10.1371/annotation/fd6f4425-3d84-4017-a012-a5df6ddee13a.
Tengvall, K., Kierczak, M., Bergvall, K., Olsson, M., Frankowiack, M., Farias, F.H., Pielberg, G., Carlborg, Ö., Leeb, T., Andersson, G., Hammarström, L., Hedhammar, Å., Lindblad-Toh, K. :
Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitis. PLoS Genet 9:e1003475, 2013. Pubmed reference: 23671420. DOI: 10.1371/journal.pgen.1003475.
2012 Campora, L., Miragliotta, V., Ricci, E., Cristino, L., Di Marzo, V., Albanese, F., Federica Della Valle, M., Abramo, F. :
Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis. Am J Vet Res 73:988-95, 2012. Pubmed reference: 22738050. DOI: 10.2460/ajvr.73.7.988.
Kovalik, M., Thoday, K.L., Evans, H., Berry, J., van den Broek, A.H., Mellanby, R.J. :
Short-term prednisolone therapy has minimal impact on calcium metabolism in dogs with atopic dermatitis. Vet J :, 2012. Pubmed reference: 22277720. DOI: 10.1016/j.tvjl.2011.12.003.
Lauber, B., Molitor, V., Meury, S., Doherr, M.G., Favrot, C., Tengvall, K., Bergvall, K., Leeb, T., Roosje, P., Marti, E. :
Total IgE and allergen-specific IgE and IgG antibody levels in sera of atopic dermatitis affected and non-affected Labrador- and Golden retrievers. Vet Immunol Immunopathol 149:112-8, 2012. Pubmed reference: 22739207. DOI: 10.1016/j.vetimm.2012.05.018.
Marsella, R., Sousa, C.A., Gonzales, A.J., Fadok, V.A. :
Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc 241:194-207, 2012. Pubmed reference: 22765366. DOI: 10.2460/javma.241.2.194.
Olivry, T. :
What can dogs bring to atopic dermatitis research? Chem Immunol Allergy 96:61-72, 2012. Pubmed reference: 22433372. DOI: 10.1159/000331884.
Plager, D.A., Torres, S.M., Koch, S.N., Kita, H. :
Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases. Vet Immunol Immunopathol 149:136-42, 2012. Pubmed reference: 22749291. DOI: 10.1016/j.vetimm.2012.06.003.
Plant, J.D., Gortel, K., Kovalik, M., Polissar, N.L., Neradilek, M.B. :
Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis. Vet Dermatol 23:515-e103, 2012. Pubmed reference: 23140318. DOI: 10.1111/j.1365-3164.2012.01113.x.
Roque, J.B., O'Leary, C.A., Duffy, D.L., Kyaw-Tanner, M., Gharahkhani, P., Vogelnest, L., Mason, K., Shipstone, M., Latter, M. :
Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17. Immunogenetics 64:209-17, 2012. Pubmed reference: 21989516. DOI: 10.1007/s00251-011-0577-x.
Theerawatanasirikul, S., Sailasuta, A., Thanawongnuwech, R., Suriyaphol, G. :
Alterations of keratins, involucrin and filaggrin gene expression in canine atopic dermatitis. Res Vet Sci 93:1287-92, 2012. Pubmed reference: 22784629. DOI: 10.1016/j.rvsc.2012.06.005.
2011 Kovalik, M., Thoday, KL., Evans, H., van den Broek, AH., Mellanby, RJ. :
Prednisolone is associated with an increase in serum insulin but not serum fructosamine concentrations in dogs with atopic dermatitis. Vet J :, 2011. Pubmed reference: 21745752. DOI: 10.1016/j.tvjl.2011.06.002.
Marsella, R., Olivry, T., Carlotti, D.N. :
Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Vet Dermatol 22:239-48, 2011. Pubmed reference: 21414049. DOI: 10.1111/j.1365-3164.2011.00967.x.
Meury, S., Molitor, V., Doherr, M.G., Roosje, P., Leeb, T., Hobi, S., Wilhelm, S., Favrot, C. :
Role of the environment in the development of canine atopic dermatitis in Labrador and golden retrievers. Vet Dermatol 22:327-34, 2011. Pubmed reference: 21251098. DOI: 10.1111/j.1365-3164.2010.00950.x.
Olivry, T. :
Is the skin barrier abnormal in dogs with atopic dermatitis? Vet Immunol Immunopathol :, 2011. Pubmed reference: 21835476. DOI: 10.1016/j.vetimm.2011.07.014.
Roque, J.B., O'Leary, C.A., Kyaw-Tanner, M., Duffy, D.L., Gharahkhani, P., Vogelnest, L., Mason, K., Shipstone, M. :
PTPN22 polymorphisms may indicate a role for this gene in atopic dermatitis in West Highland white terriers. BMC Res Notes 4:571, 2011. Pubmed reference: 22208456. DOI: 10.1186/1756-0500-4-571.
Salzmann, C.A., Olivry, T.J., Nielsen, D.M., Paps, J.S., Harris, T.L., Olby, N.J. :
Genome-wide linkage study of atopic dermatitis in West Highland White Terriers. BMC Genet 12:37, 2011. Pubmed reference: 21510878. DOI: 10.1186/1471-2156-12-37.
2010 Chervet, L., Galichet, A., McLean, W.H., Chen, H., Suter, M.M., Roosje, P.J., Müller, E.J. :
Missing C-terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis. Exp Dermatol 19:e343-6, 2010. Pubmed reference: 20626465. DOI: 10.1111/j.1600-0625.2010.01109.x.
Favrot, C., Steffan, J., Seewald, W., Picco, F. :
A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 21:23-31, 2010. Pubmed reference: 20187911. DOI: 10.1111/j.1365-3164.2009.00758.x.
Jaeger, K., Linek, M., Power, H.T., Bettenay, S.V., Zabel, S., Rosychuk, R.A., Mueller, R.S. :
Breed and site predispositions of dogs with atopic dermatitis: a comparison of five locations in three continents. Vet Dermatol 21:118-22, 2010. Pubmed reference: 20187918. DOI: 10.1111/j.1365-3164.2009.00845.x.
Marsella, R. :
Canine atopic dermatitis: what's new? Compend Contin Educ Vet 32:E1-4, 2010. Pubmed reference: 20473848.
Olivry, T. :
New diagnostic criteria for canine atopic dermatitis. Vet Dermatol 21:123-6, 2010. Pubmed reference: 20187919. DOI: 10.1111/j.1365-3164.2009.00776.x.
Olivry, T., Foster, AP., Mueller, RS., McEwan, NA., Chesney, C., Williams, HC. :
Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials. Vet Dermatol 21:4-22, 2010. Pubmed reference: 20187909. DOI: 10.1111/j.1365-3164.2009.00873.x.
2009 Marsella, R., Girolomoni, G. :
Canine models of atopic dermatitis: a useful tool with untapped potential. J Invest Dermatol 129:2351-7, 2009. Pubmed reference: 19516261. DOI: 10.1038/jid.2009.98.
Marsella, R., Samuelson, D. :
Unravelling the skin barrier: a new paradigm for atopic dermatitis and house dust mites. Vet Dermatol 20:533-40, 2009. Pubmed reference: 20178491. DOI: 10.1111/j.1365-3164.2009.00809.x.
Wood, S.H., Clements, D.N., Ollier, W.E., Nuttall, T., McEwan, N.A., Carter, S.D. :
Gene expression in canine atopic dermatitis and correlation with clinical severity scores. J Dermatol Sci 55:27-33, 2009. Pubmed reference: 19394200. DOI: 10.1016/j.jdermsci.2009.03.005.
Wood, S.H., Ke, X., Nuttall, T., McEwan, N., Ollier, W.E., Carter, S.D. :
Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs. Immunogenetics 61:765-72, 2009. Pubmed reference: 19838693. DOI: 10.1007/s00251-009-0402-y.
2008 Keppel, KE., Campbell, KL., Zuckermann, FA., Greeley, EA., Schaeffer, DJ., Husmann, RJ. :
Quantitation of canine regulatory T cell populations, serum interleukin-10 and allergen-specific IgE concentrations in healthy control dogs and canine atopic dermatitis patients receiving allergen-specific immunotherapy. Vet Immunol Immunopathol 123:337-44, 2008. Pubmed reference: 18423890. DOI: 10.1016/j.vetimm.2008.02.008.
2007 Nødtvedt, A., Guitian, J., Egenvall, A., Emanuelson, U., Pfeiffer, D.U. :
The spatial distribution of atopic dermatitis cases in a population of insured Swedish dogs. Prev Vet Med 78:210-22, 2007. Pubmed reference: 17112611. DOI: 10.1016/j.prevetmed.2006.10.007.
2006 Breathnach, R., Donahy, C., Jones, B.R., Bloomfield, F.J. :
Increased leukotriene B(4) production, complement C3 conversion and acid hydrolase enzyme concentrations in different leucocyte sub-populations of dogs with atopic dermatitis. Vet J 171:106-13, 2006. Pubmed reference: 16427587. DOI: 10.1016/j.tvjl.2004.09.012.
Nødtvedt, A., Egenvall, A., Bergvall, K., Hedhammar, A. :
Incidence of and risk factors for atopic dermatitis in a Swedish population of insured dogs. Vet Rec 159:241-6, 2006. Pubmed reference: 16921013.
Steffan, J., Favrot, C., Mueller, R. :
A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Vet Dermatol 17:3-16, 2006. Pubmed reference: 16412115. DOI: 10.1111/j.1365-3164.2005.00491.x.
Tarpataki, N. :
Recent developments in canine atopic dermatitis: a review. Acta Vet Hung 54:473-84, 2006. Pubmed reference: 17278719. DOI: 10.1556/AVet.54.2006.4.5.
2005 Colombo, S., Hill, PB., Shaw, DJ., Thoday, KL. :
Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study. Vet Dermatol 16:162-70, 2005. Pubmed reference: 15960629. DOI: 10.1111/j.1365-3164.2005.00453.x.
Hou, CC., Pemberton, A., Nuttall, T., Hill, PB. :
IgG responses to antigens from Dermatophagoides farinae in healthy and atopic dogs. Vet Immunol Immunopathol 106:121-8, 2005. Pubmed reference: 15910999. DOI: 10.1016/j.vetimm.2005.01.011.
Maeda, S., Tsukui, T., Saze, K., Masuda, K., Ohno, K., Tsujimoto, H., Iwabuchi, S. :
Production of a monoclonal antibody to canine thymus and activation-regulated chemokine (TARC) and detection of TARC in lesional skin from dogs with atopic dermatitis. Vet Immunol Immunopathol 103:83-92, 2005. Pubmed reference: 15626464. DOI: 10.1016/j.vetimm.2004.08.021.
McEwan, NA., Kalna, G., Mellor, D. :
A comparison of adherence by four strains of Staphylococcus intermedius and Staphylococcus hominis to canine corneocytes collected from normal dogs and dogs suffering from atopic dermatitis. Res Vet Sci 78:193-8, 2005. Pubmed reference: 15766937. DOI: 10.1016/j.rvsc.2004.09.002.
Mueller, R.S., Fieseler, K.V., Rosychuk, R.A., Greenwalt, T. :
Intradermal testing with the storage mite Tyrophagus putrescentiae in normal dogs and dogs with atopic dermatitis in Colorado. Vet Dermatol 16:27-31, 2005. Pubmed reference: 15725102. DOI: 10.1111/j.1365-3164.2005.00415.x.
Mueller, RS., Fettman, MJ., Richardson, K., Hansen, RA., Miller, A., Magowitz, J., Ogilvie, GK. :
Plasma and skin concentrations of polyunsaturated fatty acids before and after supplementation with n-3 fatty acids in dogs with atopic dermatitis. Am J Vet Res 66:868-73, 2005. Pubmed reference: 15934614.
Steffan, J., Parks, C., Seewald, W. :
Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitis. J Am Vet Med Assoc 226:1855-63, 2005. Pubmed reference: 15934253.
2004 Marsella, R., Nicklin, CF., Saglio, S., Lopez, J. :
Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic) in canine atopic dermatitis: a randomized, double-blinded, placebo-controlled, cross-over study. Vet Dermatol 15:294-303, 2004. Pubmed reference: 15500481. DOI: 10.1111/j.1365-3164.2004.00397.x.
Mueller, R.S., Chapman, P.L. :
Cross reactivity of airborne allergens based on 1000 intradermal test results. Aust Vet J 82:351-4, 2004. Pubmed reference: 15267094.
Mueller, R.S., Fieseler, K.V., Fettman, M.J., Zabel, S., Rosychuk, R.A., Ogilvie, G.K., Greenwalt, T.L. :
Effect of omega-3 fatty acids on canine atopic dermatitis. J Small Anim Pract 45:293-7, 2004. Pubmed reference: 15206474.
Shaw, SC., Wood, JL., Freeman, J., Littlewood, JD., Hannant, D. :
Estimation of heritability of atopic dermatitis in Labrador and Golden Retrievers. Am J Vet Res 65:1014-20, 2004. Pubmed reference: 15281664.
Shida, M., Kadoya, M., Park, SJ., Nishifuji, K., Momoi, Y., Iwasaki, T. :
Allergen-specific immunotherapy induces Th1 shift in dogs with atopic dermatitis. Vet Immunol Immunopathol 102:19-31, 2004. Pubmed reference: 15451612. DOI: 10.1016/j.vetimm.2004.06.003.
2003 Arlian, L.G., Schumann, R.J., Morgan, M.S., Glass, R.L. :
Serum immunoglobulin E against storage mite allergens in dogs with atopic dermatitis American Journal of Veterinary Research 64:32-36, 2003. Pubmed reference: 12518875.
Graham, L.F., Torres, S.M., Jessen, C.R., Horne, K.L., Hendrix, P.K. :
Effects of propofol-induced sedation on intradermal test reactions in dogs with atopic dermatitis Veterinary Dermatology 14:167-76, 2003. Pubmed reference: 12791051.
Olivry, T., Mueller, R.S., The International Task Force on Canine Atopic Derm :
Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis.[comment] Veterinary Dermatology 14:121-46, 2003. Pubmed reference: 12791047.
2002 Egli, K.S., Schiessl, B., Roosje, P.J., Seewald, W.L., Forster, U., Peel, J.E., Welle, M.M. :
Evaluation of the usefulness of sensitization to aeroallergens as a model for canine atopic dermatitis in genetically predisposed Beagles American Journal of Veterinary Research 63:1329-1336, 2002. Pubmed reference: 12224870.
Hillier, A. :
Allergy testing and treatment for canine atopic dermatitis Veterinary Medicine 97:210-+, 2002.
Hillier, A. :
Definitively diagnosing atopic dermatitis in dogs Veterinary Medicine 97:198-+, 2002.
Hillier, A. :
Symposium on atopic dermatitis Veterinary Medicine 97:196, 2002.
Jackson, H.A., Orton, S.M., Hammerberg, B. :
IgE is present on peripheral blood monocytes and B cells in normal dogs and dogs with atopic dermatitis but there is no correlation with serum IgE concentrations Veterinary Immunology & Immunopathology 85:225-232, 2002.
Jouppi, R. :
Response to the letters regarding the treatment of canine atopic dermatitis with a homeopathic remedy Canadian Veterinary Journal - Revue Veterinaire Canadienne 43:910-911, 2002.
Maeda, S., Fujiwara, S., Omori, K., Kawano, K., Kurata, K., Masuda, K., Ohno, K., Tsujimoto, H. :
Lesional expression of thymus and activation-regulated chemokine in canine atopic dermatitis Veterinary Immunology & Immunopathology 88:79-87, 2002.
Mueller, R.S., Chapman, P.L., Rosychuk, R.E.W., Bettenay, S.V., Fieseler, K.V. :
Evaluation of cross-reactivity of allergens by use of intradermal testing in atopic dogs American Journal of Veterinary Research 63:874-879, 2002. Pubmed reference: 12061535.
Nuttall, T.J., Knight, P.A., McAleese, S.M., Lamb, J.R., Hill, P.B. :
T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis Veterinary Immunology & Immunopathology 87:379-384, 2002.
Nuttall, T.J., Knight, P.A., McAleese, S.M., Lamb, J.R., Hill, P.B. :
Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis Clinical & Experimental Allergy 32:789-795, 2002.
Nuttall, T.J., Pemberton, A.D., Lamb, J.R., Hill, P.B. :
Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis Veterinary Immunology & Immunopathology 84:143-150, 2002.
Olivry, T., Rivierre, C., Jackson, H.A., Murphy, K.M., Davidson, G., Sousa, C.A. :
Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial Veterinary Dermatology 13:77-87, 2002. Pubmed reference: 11972891.
Scott, D.W., Miller, W.H., Senter, D.A., Cook, C.P., Kirker, J.E., Cobb, S.M. :
Treatment of canine atopic dermatitis with a commercial homeopathic remedy: A single-blinded, placebo-controlled study Canadian Veterinary Journal - Revue Veterinaire Canadienne 43:601-603, 2002.
Sinke, J.D., Rutten, V.P.M.G., Willemse, T. :
Immune dysregulation in atopic dermatitis Veterinary Immunology & Immunopathology 87:351-356, 2002.
Yamashita, K., Fujiwara, C., Azuma, R., Sawazaki, T., Nakao, Y., Hasegawa, A. :
Determination of antigenic proteins of Housedust mites in 90 dogs suffering from atopic dermatitis Journal of Veterinary Medical Science 64:673-676, 2002. Pubmed reference: 12237510.
Zur, G., Ihrke, P.J., White, S.D., Kass, P.H. :
Canine atopic dermatitis: a retrospective study of 266 cases examined at the University of California, Davis, 1992-1998. Part I. Clinical features and allergy testing results Veterinary Dermatology 13:89-102, 2002. Pubmed reference: 11972892.
Zur, G., White, S.D., Ihrke, P.J., Kass, P.H., Toebe, N. :
Canine atopic dermatitis: a retrospective study of 169 cases examined at the University of California, Davis, 1992-1998. Part II. Response to hyposensitization Veterinary Dermatology 13:103-111, 2002. Pubmed reference: 11972893.
2001 DeBoer, D.J., Griffin, C.E. :
The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy. Vet Immunol Immunopathol 81:323-9, 2001. Pubmed reference: 11553395.
DeBoer, D.J., Hillier, A. :
The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet Immunol Immunopathol 81:271-6, 2001. Pubmed reference: 11553389.
DeBoer, D.J., Hillier, A. :
The ACVD task force on canine atopic dermatitis (XVI): laboratory evaluation of dogs with atopic dermatitis with serum-based "allergy" tests. Vet Immunol Immunopathol 81:277-87, 2001. Pubmed reference: 11553390.
DeBoer, D.J., Marsella, R. :
The ACVD task force on canine atopic dermatitis (XII): the relationship of cutaneous infections to the pathogenesis and clinical course of canine atopic dermatitis. Vet Immunol Immunopathol 81:239-49, 2001. Pubmed reference: 11553386.
Griffin, C.E., DeBoer, D.J. :
The ACVD task force on canine atopic dermatitis (XIV): clinical manifestations of canine atopic dermatitis. Vet Immunol Immunopathol 81:255-69, 2001. Pubmed reference: 11553388.
Griffin, C.E., Hillier, A. :
The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy. Vet Immunol Immunopathol 81:363-83, 2001. Pubmed reference: 11553398.
Halliwell, R.E., DeBoer, D.J. :
The ACVD task force on canine atopic dermatitis (III): the role of antibodies in canine atopic dermatitis. Vet Immunol Immunopathol 81:159-67, 2001. Pubmed reference: 11553377.
Hill, P.B., DeBoer, D.J. :
The ACVD task force on canine atopic dermatitis (IV): environmental allergens. Vet Immunol Immunopathol 81:169-86, 2001. Pubmed reference: 11553378.
Hill, P.B., Hillier, A., Olivry, T. :
The ACVD task force on canine atopic dermatitis (VI): IgE-induced immediate and late-phase reactions, two inflammatory sequences at sites of intradermal allergen injections. Vet Immunol Immunopathol 81:199-204, 2001. Pubmed reference: 11553380.
Hill, P.B., Olivry, T. :
The ACVD task force on canine atopic dermatitis (V): biology and role of inflammatory cells in cutaneous allergic reactions. Vet Immunol Immunopathol 81:187-98, 2001. Pubmed reference: 11553379.
Hillier, A., DeBoer, D.J. :
The ACVD task force on canine atopic dermatitis (XVII): intradermal testing. Vet Immunol Immunopathol 81:289-304, 2001. Pubmed reference: 11553391.
Hillier, A., Griffin, C.E. :
The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions? Vet Immunol Immunopathol 81:227-31, 2001. Pubmed reference: 11553384.
Hillier, A., Griffin, C.E. :
The ACVD task force on canine atopic dermatitis (I): incidence and prevalence. Vet Immunol Immunopathol 81:147-51, 2001. Pubmed reference: 11553375.
Marsella, R., Olivry, T. :
The ACVD task force on canine atopic dermatitis (VII): mediators of cutaneous inflammation. Vet Immunol Immunopathol 81:205-13, 2001. Pubmed reference: 11553381.
Marsella, R., Olivry, T. :
The ACVD task force on canine atopic dermatitis (XXII): nonsteroidal anti-inflammatory pharmacotherapy. Vet Immunol Immunopathol 81:331-45, 2001. Pubmed reference: 11553396.
Marsella, R., Sousa, C.A. :
The ACVD task force on canine atopic dermatitis (XIII): threshold phenomenon and summation of effects. Vet Immunol Immunopathol 81:251-4, 2001. Pubmed reference: 11553387.
Mueller, R.S., Bettenay, S.V. :
Evaluation of the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. Am J Vet Res 62:307-10, 2001. Pubmed reference: 11277192.
Nuttall, T.J., Halliwell, R.E.W. :
Serum antibodies to Malassezia yeasts in canine atopic dermatitis Veterinary Dermatology 12:327-332, 2001. Pubmed reference: 11844222.
Nuttall, T.J., Lamb, J.R., Hill, P.B. :
Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis Veterinary Immunology & Immunopathology 82:273-280, 2001.
Nuttall, T.J., Lamb, J.R., Hill, P.B. :
Characterisation of major and minor Dermatophagoides allergens in canine atopic dermatitis Research in Veterinary Science 71:51-57, 2001. Pubmed reference: 11666148. DOI: 10.1053/rvsc.2001.0485.
Olivry, T., DeBoer, D.J., Griffin, C.E., Halliwell, R.E., Hill, P.B., Hillier, A., Marsella, R., Sousa, C.A. :
The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol 81:143-6, 2001. Pubmed reference: 11553374.
Olivry, T., Hill, P.B. :
The ACVD task force on canine atopic dermatitis (IX): the controversy surrounding the route of allergen challenge in canine atopic dermatitis. Vet Immunol Immunopathol 81:219-25, 2001. Pubmed reference: 11553383.
Olivry, T., Hill, P.B. :
The ACVD task force on canine atopic dermatitis (XVIII): histopathology of skin lesions. Vet Immunol Immunopathol 81:305-9, 2001. Pubmed reference: 11553392.
Olivry, T., Hill, P.B. :
The ACVD task force on canine atopic dermatitis (VIII): is the epidermal lipid barrier defective? Vet Immunol Immunopathol 81:215-8, 2001. Pubmed reference: 11553382.
Olivry, T., Marsella, R., Hillier, A. :
The ACVD task force on canine atopic dermatitis (XXIII): are essential fatty acids effective? Vet Immunol Immunopathol 81:347-62, 2001. Pubmed reference: 11553397.
Olivry, T., Sousa, C.A. :
The ACVD task force on canine atopic dermatitis (XIX): general principles of therapy. Vet Immunol Immunopathol 81:311-6, 2001. Pubmed reference: 11553393.
Olivry, T., Sousa, C.A. :
The ACVD task force on canine atopic dermatitis (XX): glucocorticoid pharmacotherapy. Vet Immunol Immunopathol 81:317-22, 2001. Pubmed reference: 11553394.
Rees, C.A. :
Canine and feline atopic dermatitis: A review of the diagnostic options Clinical Techniques in Small Animal Practice 16:230-232, 2001. Pubmed reference: 11793877. DOI: 10.1053/svms.2001.27600.
Sousa, C.A., Halliwell, R.E. :
The ACVD task force on canine atopic dermatitis (XI): the relationship between arthropod hypersensitivity and atopic dermatitis in the dog. Vet Immunol Immunopathol 81:233-7, 2001. Pubmed reference: 11553385.
Sousa, C.A., Marsella, R. :
The ACVD task force on canine atopic dermatitis (II): genetic factors. Vet Immunol Immunopathol 81:153-7, 2001. Pubmed reference: 11553376.
2000 Masuda, K., Tsujimoto, H., Fujiwara, S., Kurata, K., Hasegawa, A., Taniguchi, Y., Yamashita, K., Yasueda, H., DeBoer, D.J., de, Weck, A.L., Sakaguchi, M. :
IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis Veterinary Immunology & Immunopathology 74:263-270, 2000.
McEwan, N.A. :
Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis Research in Veterinary Science 68:279-283, 2000. Pubmed reference: 10877976. DOI: 10.1053/rvsc.2000.0378.
Mueller, R.S., Bettenay, S.V., Tideman, L. :
Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests Australian Veterinary Journal 78:392-399, 2000. Pubmed reference: 10920777.
1999 DeBoer, D.J., Hill, P.B. :
Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis Veterinary Dermatology 10:275-281, 1999.
Mueller, R.S., Burrows, A., Tsohalis, J. :
Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs Australian Veterinary Journal 77:290-294, 1999. Pubmed reference: 10376096.
1998 Hammerling, R., Leidinger, K. :
Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German] Praktische Tierarzt 79:509 ff., 1998.
Prelaud, P., Guaguere, E., Alhaidari, Z., Faivre, N., Heripret, D., Gayerie, A. :
Reevaluation of diagnostic criteria of canine atopic dermatitis [French] Revue de Medecine Veterinaire 149:1057-1064, 1998.
1997 Mueller, R.S., Cannon, A., Reubl, G.H., Ihrke, P.J. :
Serum and skin IgA concentrations in normal and atopic dogs Australian Veterinary Journal 75:906-909, 1997. Pubmed reference: 9469228.
Olivry, T., Naydan, D.K., Moore, P.F. :
Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis American Journal of Dermatopathology 19:477-486, 1997. Pubmed reference: 9335242.
1996 Olivry, T., Moore, P.F., Affolter, V.K., Naydan, D.K. :
Langerhans cell hyperplasia and ige expression in canine atopic dermatitis Archives of Dermatological Research 288:579-585, 1996. Pubmed reference: 8919040.
1994 Koch, H.J., Peters, S. :
207 Intracutaneous Tests in Dogs with Suspicion of Atopic Dermatitis Kleintierpraxis 39:25-36, 1994.
1974 Austin, V.H. :
Incidence of atopic dermatitis in dogs. Mod Vet Pract 55:304, 1974. Pubmed reference: 4824804.
Chamberlain, K.W. :
Atopic (allergic) dermatitis. Vet Clin North Am 4:29-39, 1974. Pubmed reference: 4406238.
1971 Halliwell, R.E. :
Atopic disease in the dog. Vet Rec 89:209-14, 1971. Pubmed reference: 5106212.
1963 Morris, G.E. :
Dod-hair dermatitis. Med Times 91:1013-4, 1963. Pubmed reference: 14047883.

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  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 17 May 2013
  • Changed by Frank Nicholas on 20 May 2013
  • Changed by Frank Nicholas on 21 May 2013
  • Changed by Frank Nicholas on 02 Jun 2016