OMIA:000271-9823 : Dermatosis vegetans in Sus scrofa (pig)

Categories: Integument (skin) phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: Club foot

Species-specific description: This disorder occurs only in Landrace pigs. It is a well-characterised syndrome comprising skin lesions on the body, swollen feet (club foot), and multinucleate giant cells (MGC) in the lungs, associated with fatal pneumonia. Evensen (1993) showed that the giant cells in the lungs of affected pigs are derived from mesenchymal cells, with a monocyte/macrophage origin.

Inheritance: Breeding data support single-locus autosomal recessive inheritance (Flatla et al., 1961).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Landrace (Pig) (VBO_0001161).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:000271-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1993 Evensen, O. :
An Immunohistochemical Study on the Cytogenetic Origin of Pulmonary Multinucleate Giant Cells in Porcine Dermatosis Vegetans Veterinary Pathology 30:162-170, 1993. Pubmed reference: 7682369.
1987 Pin, F.Z., Wang, J.Y., Hu, W.P., Wang, B.A., Wang, H.D. :
[Study on dermatosis vegetans in pigs] Journal of Jiangsu Agricultural College 8:37-40, 1987.
1974 Glawischnig, E., Swoboda, R., Schlecht, H. :
Zum Vorkommen der Dermatosis Vegetans des Schweines in Osterreich Deutsche Tierarztliche Wochenschrift 81:5-9, 1974. Pubmed reference: 4591465.
Jericho, K.W.F. :
Dermatosis vegetans - giant cell pneumonitis in pigs: further observations and interpretations Research in Veterinary Science 16:176-181, 1974. Pubmed reference: 4830981.
1967 Done, J.T., Loosmore, R.M., Saunders, C.N. :
Dermatosis vegetans in pigs Veterinary Record 80:292-297, 1967. Pubmed reference: 6067656.
1961 Flatla, J.L., Hansen, M.A., Slagsvold, P. :
Dermatosis vegetans in pigs : symptomatology and genetics Zentralblatt fur Veterinarmedizin 8:25-42, 1961.
1953 Hjarre, A. :
Vegetierende Dermatosen mit Riesenzellenpneumonien beim Schwein Deutsche Tierarztliche Wochenschrift 60:106-110, 1953.
Larsson, E. :
"Klumpfotgrisar" [Club-footed pigs] Svenska Svinavelsforeningens Tidskr. 1:1-15, 1953.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 29 Oct 2022