OMIA:000271-9823 : Dermatosis vegetans in Sus scrofa (pig)
Categories: Integument (skin) phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific name: Club foot
Species-specific description: This disorder occurs only in Landrace pigs. It is a well-characterised syndrome comprising skin lesions on the body, swollen feet (club foot), and multinucleate giant cells (MGC) in the lungs, associated with fatal pneumonia. Evensen (1993) showed that the giant cells in the lungs of affected pigs are derived from mesenchymal cells, with a monocyte/macrophage origin.
Inheritance: Breeding data support single-locus autosomal recessive inheritance (Flatla et al., 1961).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Landrace (Pig) (VBO_0001161).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1993||Evensen, O. :|
|An Immunohistochemical Study on the Cytogenetic Origin of Pulmonary Multinucleate Giant Cells in Porcine Dermatosis Vegetans Veterinary Pathology 30:162-170, 1993. Pubmed reference: 7682369.|
|1987||Pin, F.Z., Wang, J.Y., Hu, W.P., Wang, B.A., Wang, H.D. :|
|[Study on dermatosis vegetans in pigs] Journal of Jiangsu Agricultural College 8:37-40, 1987.|
|1974||Glawischnig, E., Swoboda, R., Schlecht, H. :|
|Zum Vorkommen der Dermatosis Vegetans des Schweines in Osterreich Deutsche Tierarztliche Wochenschrift 81:5-9, 1974. Pubmed reference: 4591465.|
|Jericho, K.W.F. :|
|Dermatosis vegetans - giant cell pneumonitis in pigs: further observations and interpretations Research in Veterinary Science 16:176-181, 1974. Pubmed reference: 4830981.|
|1967||Done, J.T., Loosmore, R.M., Saunders, C.N. :|
|Dermatosis vegetans in pigs Veterinary Record 80:292-297, 1967. Pubmed reference: 6067656.|
|1961||Flatla, J.L., Hansen, M.A., Slagsvold, P. :|
|Dermatosis vegetans in pigs : symptomatology and genetics Zentralblatt fur Veterinarmedizin 8:25-42, 1961.|
|1953||Hjarre, A. :|
|Vegetierende Dermatosen mit Riesenzellenpneumonien beim Schwein Deutsche Tierarztliche Wochenschrift 60:106-110, 1953.|
|Larsson, E. :|
|"Klumpfotgrisar" [Club-footed pigs] Svenska Svinavelsforeningens Tidskr. 1:1-15, 1953.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 29 Oct 2022