OMIA:000359-9615 : Eyelid gland, third, prolapse of in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Vision / eye phene

Mendelian trait/disorder: no

Considered a defect: yes

Key variant known: no

Cross-species summary: Also known as Prolapsed nictitating membrane gland (PNMG) or cherry eye

Mapping: Freyer et al. (2024) "several thousand cases and controls for cherry eye in both purebred dogs and mixed breeds [were] used for a large-scale GWAS, revealing a single peak of genome-wide significance on canine chromosome 18, directly at the location of the previously identified FGF4 insertion [FGF4L1] known to cause chondrodysplasia in several breeds."

Breeds: American Cocker Spaniel (Dog) (VBO_0200038), Boston Terrier (Dog) (VBO_0200204), English Bulldog (Dog) (VBO_0200485), French Bulldog (Dog) (VBO_0201455), Great Dane (Dog) (VBO_0200623), Italian Cane Corso (Dog) (VBO_0200712), Lhasa Apso (Dog) (VBO_0200824), Neapolitan Mastiff (Dog) (VBO_0200930).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000359-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Freyer, J., Labadie, J.D., Huff, J.T., Denyer, M., Forman, O.P., Chodroff Foran, R., Donner, J. :
Association of FGF4L1 retrogene insertion with prolapsed gland of the nictitans (Cherry Eye) in dogs. Genes (Basel) 15:198, 2024. Pubmed reference: 38397188. DOI: 10.3390/genes15020198.
2022 O'Neill, D.G., Yin, Y., Tetas Pont, R., Brodbelt, D.C., Church, D.B., Pegram, C., Mustikka, M. :
Breed and conformational predispositions for prolapsed nictitating membrane gland (PNMG) in dogs in the UK: A VetCompass study. PLoS One 17:e0260538, 2022. Pubmed reference: 35081121. DOI: 10.1371/journal.pone.0260538.
2021 Genetics Committee of the American College of Veterinary Opthalmologists :
The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition , 2021.
2013 Edelmann, M.L., Miyadera, K., Iwabe, S., Kom√°romy, A.M. :
Investigating the inheritance of prolapsed nictitating membrane glands in a large canine pedigree. Vet Ophthalmol 16:416-22, 2013. Pubmed reference: 23240682. DOI: 10.1111/vop.12015.
2012 Mazzucchelli, S., Vaillant, M.D., Wéverberg, F., Arnold-Tavernier, H., Honegger, N., Payen, G., Vanore, M., Liscoet, L., Thomas, O., Clerc, B., Chahory, S. :
Retrospective study of 155 cases of prolapse of the nictitating membrane gland in dogs. Vet Rec 170:443, 2012. Pubmed reference: 22472538. DOI: 10.1136/vr.100587.

Edit History

  • Created by Frank Nicholas on 05 Jun 2019
  • Changed by Imke Tammen2 on 12 Feb 2023
  • Changed by Imke Tammen2 on 17 Jun 2023
  • Changed by Imke Tammen2 on 08 Apr 2024