OMIA:000380-9103 : Feathering, Z-linked in Meleagris gallopavo |
In other species: chicken , helmeted guineafowl
Categories: Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 176761 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Z-linked
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2018
Species-specific description: Derks et al. (2018) suspect that the form of Z-linked feathering described in this OMIA entry "differs from a late feathering phenotype that was described in turkey by Asmundson and Abbott [1960]"
History: This trait was first reported by Zakrzewska and Savage (1997)
Inheritance: As in chickens, the locus is Z-linked, and slow-feathering is dominant to fast or rapid feathering (the wild type) (Zakrzewska and Savage, 1997)
Mapping: Via a GWAS of SNPs called from whole-genome sequencing of 12 slow-feathering and 12 fast-feathering turkeys from a commercial line, Derks et al. (2018) mapped this trait to "the short arm of the Z chromosome between 7.95 and 9.79 Mb"
Molecular basis: Derks et al. (2018) "identified a 5-bp frameshift deletion in the prolactin receptor (PRLR) gene that is responsible for slow feathering at hatch. All female cases (SF turkeys) were hemizygous for this deletion, while 188 controls (FF turkeys) were hemizygous or homozygous for the reference allele. This frameshift mutation introduces a premature stop codon and six novel amino acids (AA), which results in a truncated PRLR protein that lacks 98 C-terminal AA . . . this truncated PRLR protein is strikingly similar to the protein encoded by the slow feathering K allele in chicken." (see OMIA 000380-9031)
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| PRLR | prolactin receptor | Meleagris gallopavo | Z | NC_015041.2 (9446225..9425540) | PRLR | Homologene, Ensembl , NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Inferred EVA rsID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 977 | Feathering, Z-linked | PRLR | deletion, small (<=20) | Naturally occurring variant | Turkey_5.1 | Z | g.9426018_9426022delTTGGT | p.(E726Dfs*7) | 2018 | 29566646 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2018 | Derks, M.F.L., Herrero-Medrano, J.M., Crooijmans, R.P.M.A., Vereijken, A., Long, J.A., Megens, H.J., Groenen, M.A.M. : |
| Early and late feathering in turkey and chicken: same gene but different mutations. Genet Sel Evol 50:7, 2018. Pubmed reference: 29566646 . DOI: 10.1186/s12711-018-0380-3. | |
| 2008 | Renema, R.A., Sikur, V.R., Robinson, F.E., Korver, D.R., Zuidhof, M.J. : |
| Effects of nutrient density and age at photostimulation on carcass traits and reproductive efficiency in fast- and slow-feathering turkey hens. Poult Sci 87:1897-908, 2008. Pubmed reference: 18753460 . DOI: 10.3382/ps.2007-00431. | |
| 2004 | Sikur, V.R., Robinson, F.E., Korver, D.R., Renema, R.A., Zuidhof, M.J. : |
| Effects of nutrient density on growth and carcass traits in fast- and slow-feathering female turkeys. Poultry Science 83:1507–1517, 2004. | |
| 1998 | Wylie, L.M., Hocking, P.M. : |
| Comparative study of feathering in modern and traditional turkeys. Br Poult Sci 39 Suppl:S20-1, 1998. Pubmed reference: 10188025 . | |
| 1997 | Zakrzewska, E.I., Savage, T.F. : |
| Inhibited feathering: a new dominant sex-linked gene in the turkey. Journal of Heredity 88:238-247, 1997. | |
| 1960 | Asmundson, V. S., Abbott, U. K. : |
| Dominant sex-linked slow-feathering in the turkey Poultry Science 39:1231 only, 1960. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 26 Mar 2018
- Changed by Frank Nicholas on 15 May 2020