OMIA:000437-9685 : Haemophilia A in Felis catus (domestic cat) |
In other species: crab-eating macaque , dog , horse , pig , taurine cattle , sheep
Categories: Haematopoietic system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 306700 (trait) , 300841 (gene)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Mode of inheritance: X-linked
Disease-related: yes
Key variant known: no
Cross-species summary: Also called factor VIII deficiency. Impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked. As with haemophilia B, this expectation has been confirmed in all species of mammal in which the disorder has been reported. In humans, there are hundreds of different mutations that give rise to haemophilia A. In domesticated animals, the disorder has been reported in a large range of species.
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000437-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 1990 | Littlewood, J.D., Evans, R.J. : |
| A combined deficiency of Factor-VIII and contact activation defect in a family of cats. British Veterinary Journal 146:30-35, 1990. Pubmed reference: 2306600. DOI: 10.1016/0007-1935(90)90073-C. | |
| 1988 | Fogh, J.M., Fogh, I.T. : |
| Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988. Pubmed reference: 3282382. DOI: 10.1016/s0195-5616(88)50018-9. | |
| 1982 | Dodds, W.J. : |
| An effective mass-screening program for animal models of the inherited bleeding disorders. Prog Clin Biol Res 94:117-32, 1982. Pubmed reference: 6981819. | |
| 1978 | Cotter, S.M., Brenner, R.M., Dodds, W.J. : |
| Hemophilia A in three unrelated cats. J Am Vet Med Assoc 172:166-8, 1978. Pubmed reference: 627514. |
Edit History
- Created by Frank Nicholas on 16 Jul 2005
- Changed by Frank Nicholas on 29 Aug 2013