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OMIA:000487-9913 : Hydrocephalus in Bos taurus (taurine cattle)

In other species: dog , domestic cat , tiger , puma , domestic horse , pig , llama , sheep , rabbit , golden hamster , yellow-crowned parrot

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 109400 (trait) , 112240 (trait) , 123155 (trait) , 209970 (trait) , 236600 (trait) , 236635 (trait) , 236640 (trait) , 236660 (trait) , 236670 (trait) , 236690 (trait) , 273730 (trait) , 276950 (trait) , 307000 (trait) , 307010 (trait) , 314390 (trait) , 123155 (trait) , 600257 (trait) , 600559 (trait) , 600991 (trait) , 615181 (trait)

Single-gene trait/disorder: yes

Mode of inheritance: Autosomal recessive

Disease-related: yes

Key variant known: yes

Key variant is published: no

Cross-species summary: Enlargement of the cranium caused by accumulation of fluid.

Species-specific name: Neuropathic hydrocephalus; water head

Genetic testing: A DNA test for the condition in Angus cattle has been developed by Dr Jon Beever, Department of Animal Sciences, University of Illinois.

Breeds: Angus (Cattle) (VBO_0000104), Jersey (Cattle) (VBO_0000250), Shorthorn (Cattle) (VBO_0000375).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000487-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Agerholm, J.S., Drögemüller, C., Steffen, D.J., Jacinto, J.G.P. :
An overview of developmental disorders leading to dystocia in cattle. Reprod Domest Anim 60 Suppl 3:e70083, 2025. Pubmed reference: 40899133. DOI: 10.1111/rda.70083.
Jannat, N., Tanaka, M., Izawa, T., Kobayashi, Y., Kuwamura, M. :
Expression of α-smooth muscle actin in the lateral ventricle wall of spontaneous hydrocephalus animals. J Vet Med Sci 87:934-939, 2025. Pubmed reference: 40571579. DOI: 10.1292/jvms.25-0153.
2024 Mee, J.F., Murphy, D., Curran, M. :
Bovine congenital defects recorded by veterinary practitioners. Reprod Domest Anim 59:e14501, 2024. Pubmed reference: 37975255. DOI: 10.1111/rda.14501.
2002 Sharda, R., Ingole, S.P. :
Congenital bilateral hydrocephalus in a Jersey cow calf - A case report Indian Veterinary Journal 79:965-966, 2002.
Sharda, R., Ingole, S.P. :
Congenital bilateral hydrocephalus in a Jersey cow calf - A case report (vol 79, pg 965, 2002) Indian Veterinary Journal 79:1069, 2002.
1993 Kardel, T., Bartholin, T., Stensen, N. :
Steno on hydrocephalus. Introduction to Niels Stensen's letter 'On a calf with hydrocephalus', with a short biography. J Hist Neurosci 2:171-8, 1993. Pubmed reference: 11618454. DOI: 10.1080/09647049309525566.
1978 Leech, RW., Hauges, CN., Christoferson, LA. :
Hydrocephalus, congenital hydrocephalus. Aminal model: bovine hydrocephalus, congenital internal hydrocephalus, aqueductal stenosis. Am J Pathol 92:567-70, 1978. Pubmed reference: 677272.
1977 Christoferson, LA., Leech, RW., Hazen, GA. :
Bovine hydrocephalus in North Dakota: a survey and morphologic study. Surg Neurol 7:165-70, 1977. Pubmed reference: 847630.
Leipold, H.W., Schalles, R. :
Genetic defects in cattle: transmission and control. Vet Med Small Anim Clin 72:80-5, 1977. Pubmed reference: 189478.
1971 Leipold, HW., Gelatt, KN., Huston, K. :
Multiple ocular anomalies and hydrocephalus in grade beef Shorthorn cattle. Am J Vet Res 32:1019-26, 1971. Pubmed reference: 5104395.
1967 Nuss, J.I., McCarl, R.L., Mulay, I.L., Mulay, L.N. :
Copper and free radical accumulation in liver of calves with inherited hydrocephalus American Journal of Veterinary Research 28:1909-1913, 1967. Pubmed reference: 6076576.
1964 Uman, H.K., Grace, O.D. :
Hereditary encephalopathy: a hydrocephalus syndrome in newborn calves Cornell Veterinarian 54:229-249, 1964. Pubmed reference: 14140876.
1963 Barlow, RM., Donald, LG. :
Hydrocephalus in calves associated with unusual lesions in the mesencephalon J Comp Pathol 73:410-5, 1963. Pubmed reference: 14081954.
1952 Giannotti, D. :
Cases of congenital hydrocephalus in calves Memorie Soc. Tosc. Sci. Nat. B. 59:32, 1952.
1942 Cole, C.L., Moore, L.A. :
Hydrocephalus, a lethal in cattle Journal of Agricultural Research 65:483-491, 1942.

Edit History


  • Created by Frank Nicholas on 30 Mar 2011
  • Changed by Frank Nicholas on 15 Aug 2012
  • Changed by Frank Nicholas on 21 Aug 2019
  • Changed by Imke Tammen2 on 18 Jun 2024