Categories: Integument (skin) phene

Possible human homologues (MIM numbers): 305100 (trait) , 300451 (gene)

Links to relevant human diseases in MONDO:

• MONDO:0010585: X-linked hypohidrotic ectodermal dysplasia

Cross-species summary: Ectodermal dysplasias are disorders that affect two or more organs of ectodermal origin, such as hair follicles, teeth, sweat glands, or nails. EDA-related ectodermal dysplasias have X-linked inheritance and affected animals present with hypo/adontia, hypotrichosis, and a lack of many eccrine glands. Altered tear composition may result in keratoconjunctivitis sicca and reduced or absent airway mucus production may predispose to chronic respiratory infections.
Phene has been renamed in OMIA from 'Anhidrotic ectodermal dysplasia, EDA-related' to 'Hypohidrotic ectodermal dysplasia, X-linked, EDA-related' [29/07/2024]

Species in which this phene is found:
dog (Canis lupus familiaris)
domestic cat (Felis catus)
taurine cattle (Bos taurus)
central bearded dragon (Pogona vitticeps)