In other species: dog , domestic cat

Categories: Vision / eye phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 613195 (trait) , 607511 (gene)

Single-gene trait/disorder: unknown

Disease-related: yes

Species summary: [IT thanks Emma Faull for contributions to this entry in September 2025]

Inheritance: McLean and Zimmerman (2014) concluded “the family history of this animal strongly suggested an inherited disorder. The animal's mother and sister had both suffered anterior lens luxations with no known antecedent ocular disease. The mother of this animal reportedly developed blinding glaucoma secondary to bilateral anterior lens luxations. The sister of the animal reported here also had bilateral intracapsular lens extractions.”

Clinical features: McLean and Zimmerman (2014): Ophthalamic examination of a 7-year old female captive Matschie's tree kangaroo with an opacity in the right eye revealed "minimal direct and consensual pupillary light reflexes in both eyes (OU) and the intraocular pressures were 29 mmHg OD [right eye] and 33 mmHg OS [left eye]. The menace responses and dazzle reflexes were negative, and this was attributed to the deep level of sedation. A small nictitating membrane was noted, extending dorsotemporally from the ventromedial aspect of the orbit OU. There was a focal area of full-thickness corneal edema immediately ventral of axial in the right eye. The pupils were round, the irides were dark brown, and a corpora nigra was not present OU. In the right eye, the lens was anteriorly luxated and there was an early immature anterior cortical cataract. In the left eye, the lens was clear but was subluxated and an aphakic crescent was present dorsotemporally ... the animal was diagnosed with an anterior lens luxation OD and a lens subluxation OS. Although the normal range of intraocular pressures has not been established for this species, ocular hypertension was also suspected because the measured pressures were higher than the normal values reported for other marsupials”.