OMIA:000602-9031 : Limbless in Gallus gallus (chicken)

Categories: Limbs / fins / digit / tail phene

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Species-specific symbol: ll

Mapping: Robb et al. (2011) mapped this trait to chromosome GGA 2p (29,453,912-32,073,316)

Clinical features: "Homozygotes (-/-) do not form limb buds or limbs and usually have a shortened upper beak" (Robb et al., 2011)

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000602-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2011 Robb, EA., Gitter, CL., Cheng, HH., Delany, ME. :
Chromosomal mapping and candidate gene discovery of chicken developmental mutants and genome-wide variation analysis of MHC congenics. J Hered 102:141-56, 2011. Pubmed reference: 21273214. DOI: 10.1093/jhered/esq122.
2002 McQueeney, K., Soufer, R., Dealy, C.N. :
beta-catenin-dependent Wnt signaling in apical ectodermal ridge induction and FGF8 expression in normal and limbless mutant chick limbs Development Growth & Differentiation 44:315-325, 2002.
1999 Lizarraga, G., Ferrari, D., Kalinowski, M., Ohuchi, H., Noji, S., Kosher, R.A., Dealy, C.N. :
FGFR2 signaling in normal and limbless chick limb buds Developmental Genetics 25:331-338, 1999. Pubmed reference: 10570465. DOI: 10.1002/(SICI)1520-6408(1999)25:4<331::AID-DVG7>3.0.CO;2-U.
1996 Dealy, C.N., Kosher, R.A. :
Igf-i, insulin and fgfs induce outgrowth of the limb buds of amelic mutant chick embryos Development 122:1323-1330, 1996. Pubmed reference: 8620859.
Grieshammer, U., Minowada, G., Pisenti, J.M., Abbott, U.K., Martin, G.R. :
The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning - implications for the mechanism of apical ridge formation Development 122:3851-3861, 1996. Pubmed reference: 9012506.
1992 Nohno, T., Noji, S., Koyama, E., Nishikawa, K., Myokai, F., Saito, T., Taniguchi, S. :
Differential Expression of Two msh-Related Homeobox Genes Chox-7 and Chox-8 During Chick Limb Development Biochemical and Biophysical Research Communications 182:121-128, 1992. Pubmed reference: 1346246.
1991 Coelho, C.N.D., Krabbenhoft, K.M., Upholt, W.B., Fallon, J.F., Kosher, R.A. :
Altered Expression of the Chicken Homeobox-Containing Genes GHox-7 and GHox-8 in the Limb Buds of limbless Mutant Chick Embryos Development 113:1487-1493, 1991. Pubmed reference: 1687462.
1979 Prahlad, KV., Skala, G., Jones, DG., Briles, WE. :
Limbless: a new genetic mutant in the chick. J Exp Zool 209:427-34, 1979. Pubmed reference: 490136. DOI: 10.1002/jez.1402090308.

Edit History

  • Created by Frank Nicholas on 26 Feb 2011
  • Changed by Imke Tammen2 on 07 Sep 2021