OMIA 000615-9823 : Lymphosarcoma in Sus scrofa

In other species: rabbit

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: yes

Key variant known: no

Cross-species summary: Malignant neoplastic disorder of lymphoid tissue.

Inheritance: McTaggart et al. (1979) provided convincing evidence that this disorder is autosomal recessive in pigs.

Clinical features: Stunted growth, pot-belly, enlargement of superficial lymph nodes, an increase in circulating lymphocytes, and death before 15 months of age. Postmortem examination reveals sarcoma involving all lymph nodes, but primarily those draining the gut and lung (Head et al., 1974).

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1979 McTaggart, H.S., Laing, A.H., Imlah, P., Head, K.W., Brownlie, S.E. :
The genetics of hereditary lymphosarcoma of pigs Veterinary Record 105:36 only, 1979. Pubmed reference: 583606.
1978 Brownlie, S.A., Campbell, J.G., Head, K.W., Imlah, P., McTaggart, H.S., McVie, J.G. :
Prednisolone treatment of hereditary pig lymphoma European Journal of Cancer 14:983-994, 1978. Pubmed reference: 710489.
1974 Head, K.W., Campbell, J.G., Imlah, P., Laing, A.L., Linklater, K.A., McTaggart, H.S. :
Hereditary lymphosarcoma in a herd of pigs Veterinary Record 95:523-527, 1974. Pubmed reference: 4480102.

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  • Created by Frank Nicholas on 06 Sep 2005