Categories: Lysosomal storage disease

Possible human homologues (MIM numbers): 248500 (trait) , 609458 (gene)

Links to relevant human diseases in MONDO:

• MONDO:0009561: alpha-mannosidosis

Cross-species summary: A lysosomal storage disease in which there is a buildup (storage) of mannose-rich compounds, due to the lack of the enzyme alpha-mannosidase, whose task is to cleave mannose from such compounds. Clinical signs include ataxia, head tremor, aggression, and finally paralysis and death.

Species in which this phene is found:
dog (Canis lupus familiaris)
domestic cat (Felis catus)
taurine cattle (Bos taurus)
goat (Capra hircus)
sheep (Ovis aries)
domestic guinea pig (Cavia porcellus)