OMIA:000723-9940 : Neuropathy, thalamic-cerebellar in Ovis aries (sheep)
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: A chronic locomotor disfunction characterised by mild to moderately severe pelvic limb paresis, thoracic limb hypermetria, fine mild head tremor, wide-based stance, uncoordinated gait, muscle asynergy, disturbed equilibrium and a consequent tendency to fall over (Bourke et al., 1993). On the combined basis of clinical signs and neuropathology, this disorder can be distinguished from segmental axonopathy, cerebellar axonopathy, neuroaxonal dystrophy and degenerative thoracic myelopathy. Indirect evidence suggests a genetic aetiology.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: Postmortem reveals nerve cell lesions in many thalamic neurones and many cerebellum Purkinje cells, together with fibre tract lesions in the thalamus, cerebellar peduncles, cerebellar folia, pons, medulla oblongata (ventral tracts) and spinal cord (ventral and lateral columns at all levels).
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1995||Bourke, C.A. :|
|The clinical differentiation of nervous and muscular locomotor disorders of sheep in Australia. Aust Vet J 72:228-34, 1995. Pubmed reference: 8526819.|
|1993||Bourke, C.A., Carrigan, M.J., Dent, C.H.R. :|
|Chronic locomotor dysfunction, associated with a thalamic- cerebellar neuropathy, in Australian Merino sheep. Australian Veterinary Journal 70:232-233, 1993. Pubmed reference: 8216090.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 10 Sep 2021