OMIA:000723-9940 : Neuropathy, thalamic-cerebellar in Ovis aries (sheep)

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: A chronic locomotor disfunction characterised by mild to moderately severe pelvic limb paresis, thoracic limb hypermetria, fine mild head tremor, wide-based stance, uncoordinated gait, muscle asynergy, disturbed equilibrium and a consequent tendency to fall over (Bourke et al., 1993). On the combined basis of clinical signs and neuropathology, this disorder can be distinguished from segmental axonopathy, cerebellar axonopathy, neuroaxonal dystrophy and degenerative thoracic myelopathy. Indirect evidence suggests a genetic aetiology.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: Postmortem reveals nerve cell lesions in many thalamic neurones and many cerebellum Purkinje cells, together with fibre tract lesions in the thalamus, cerebellar peduncles, cerebellar folia, pons, medulla oblongata (ventral tracts) and spinal cord (ventral and lateral columns at all levels).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000723-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1995 Bourke, C.A. :
The clinical differentiation of nervous and muscular locomotor disorders of sheep in Australia. Aust Vet J 72:228-34, 1995. Pubmed reference: 8526819.
1993 Bourke, C.A., Carrigan, M.J., Dent, C.H.R. :
Chronic locomotor dysfunction, associated with a thalamic- cerebellar neuropathy, in Australian Merino sheep. Australian Veterinary Journal 70:232-233, 1993. Pubmed reference: 8216090.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 10 Sep 2021