OMIA 000735-9913 : Ocular squamous cell carcinoma in Bos taurus

In other species: domestic cat , horse , goat , sheep

Possibly relevant human trait(s) and/or gene(s) (MIM number): 278740

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Malignant new growth of squamous epithelial cells in the eye. Also called cancer eye or eye cancer.

Species-specific name: Bovine ocular squamous cell carcinoma (BOSCC, eye cancer)

Mapping: Using a 700K SNP chip, Pausch et al. (2012) conducted a genome scan of 3,579 Flekvieh bulls with a total of 320,186 progeny classified for the extent of pigment surrounding the eyes "(ambilateral circumocular pigmentation, ACOP)", which has a strong genetic correlation with eye cancer. They identified 12 QTL regions on seven chromosomes, which in total accounted for 54% of the phenotypic variance in the proportion of daughters with ACOP.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2012 Pausch, H., Wang, X., Jung, S., Krogmeier, D., Edel, C., Emmerling, R., Götz, K.U., Fries, R. :
Identification of QTL for UV-protective eye area pigmentation in cattle by progeny phenotyping and genome-wide association analysis. PLoS One 7:e36346, 2012. Pubmed reference: 22567150. DOI: 10.1371/journal.pone.0036346.
2010 Tsujita, H., Plummer, C.E. :
Bovine ocular squamous cell carcinoma. Vet Clin North Am Food Anim Pract 26:511-29, 2010. Pubmed reference: 21056799. DOI: 10.1016/j.cvfa.2010.08.003.
2005 Carvalho, T., Vala, H., Pinto, C., Pinho, M., Peleteiro, M.C. :
Immunohistochemical studies of epithelial cell proliferation and p53 mutation in bovine ocular squamous cell carcinoma. Vet Pathol 42:66-73, 2005. Pubmed reference: 15657274. DOI: 10.1354/vp.42-1-66.
1998 Hirsbrunner, G., Ebeid, M., Eicher, R. :
Bovine ocular squamous cell carcinoma - a report of 21 cases (1990-1996) [German] Schweizer Archiv fur Tierheilkunde 140:149-155, 1998. Pubmed reference: 9581493.
1995 Den Otter, W., Hill, F.W., Klein, W.R., Koten, J.W., Steerenberg, P.A., De Mulder, P.H., Rhode, C., Stewart, R., Faber, J.A., Ruitenberg, E.J. :
Therapy of bovine ocular squamous-cell carcinoma with local doses of interleukin-2: 67% complete regressions after 20 months of follow-up. Cancer Immunol Immunother 41:10-4, 1995. Pubmed reference: 7641215.
Denotter, W., Hill, F.W.G., Klein, W.R., Everse, L.A., Ruitenberg, E.J., Vanderven, L.T.M., Koten, J.W., Steerenberg, P.A., Faber, J.A.J., Rutten, V.P.M.G. :
Ocular squamous cell carcinoma in Simmental cattle in Zimbabwe American Journal of Veterinary Research 56:1440-1444, 1995. Pubmed reference: 8585653.
1994 Fisher, M. :
Federal condemnation procedures for bovine ocular squamous cell carcinoma. Can Vet J 35:133, 1994. Pubmed reference: 8055424.
Grahn, B.H., Wolfer, J. :
Canadian condemnation rate for bovine ocular squamous cell carcinoma. Can Vet J 35:133, 1994. Pubmed reference: 17424352.
1993 Den Otter, W., Hill, F.W., Klein, W.R., Koten, J.W., Steerenberg, P.A., De Mulder, P.H., Rutten, V.P., Ruitenberg, E.J. :
Low doses of interleukin-2 can cure large bovine ocular squamous cell carcinoma. Anticancer Res 13:2453-5, 1993. Pubmed reference: 8135482.
1992 Rutten, V.P.M.G., Klein, W.R., Dejong, M.A.C., Quint, W., Denotter, W., Ruitenberg, E.J., Melchers, W.J.G. :
Search for Bovine Papilloma Virus DNA in Bovine Ocular Squamous Cell Carcinomas (BOSCC) and BOSCC-Derived Cell Lines American Journal of Veterinary Research 53:1477-1481, 1992. Pubmed reference: 1329585.
1991 Anderson, D.E. :
Genetic Study of Eye Cancer in Cattle Journal of Heredity 82:21-26, 1991. Pubmed reference: 1997589.
Anderson, D.E., Badzioch, M. :
Association Between Solar Radiation and Ocular Squamous Cell Carcinoma in Cattle American Journal of Veterinary Research 52:784-788, 1991. Pubmed reference: 1854107.
Rutten, V.P., De Jong, W.A., Klein, W.R., Den Otter, W., Steerenberg, P.A., Ruitenberg, E.J. :
Immunotherapy of bovine ocular squamous cell carcinoma: isolation, culture and characterization of lymphocytes present in the tumor. Anticancer Res 11:1259-64, 1991. Pubmed reference: 1888157.
Rutten, V.P., Klein, W.R., De Jong, W.A., Misdorp, W., Steerenberg, P.A., De Jong, W.H., Den Otter, W., Ruitenberg, E.J. :
Cancer Immunol Immunother 34:186-90, 1991. Pubmed reference: 1756535.
Walde, I., Schuh, M., Glawischnig, E. :
On the Occurrence of Ovine and Bovine Squamous Cell Carcinoma (Cancer Eye) in Austria Wiener Tierarztliche Monatsschrift 78:209-216, 1991.
1989 Rutten, V.P., Klein, W.R., De Jong, W.A., Misdorp, W., Den Otter, W., Steerenberg, P.A., De Jong, W.H., Ruitenberg, E.J. :
Local interleukin-2 therapy in bovine ocular squamous cell carcinoma. A pilot study. Cancer Immunol Immunother 30:165-9, 1989. Pubmed reference: 2598185.
Stear, M.J., Spradbrow, P.B., Tierney, T.J., Nicholas, F.W., Bellows, R.A. :
Failure to find an association between ocular squamous cell carcinoma and class I antigens of the bovine major histocompatibility system. Anim Genet 20:233-7, 1989. Pubmed reference: 2757275.
1987 Hamlet, S., Lavin, M.F. :
Bovine ocular squamous cell carcinoma: superoxide dismutase and catalase levels. Res Vet Sci 42:68-72, 1987. Pubmed reference: 3823631.
Nelson, M., Nelson, D.S., Kuchroo, V.K., Spradbrow, P.B., Jennings, P.A. :
Depression of cell-mediated immunity by tumour cell products: induction of resistance by immunotherapeutically active extracts of bovine ocular squamous cell carcinoma. Cancer Immunol Immunother 24:231-6, 1987. Pubmed reference: 3594486.
Samuel, J.L., Kelly, W.R., Vanselow, B.A. :
Intracranial invasion by bovine ocular squamous cell carcinoma via cranial nerves. Vet Rec 121:424-5, 1987. Pubmed reference: 3424607.
1986 Klein, W.R., Steerenberg, P.A., Poelma, F., vd Wiel, E., Rutten, V.P., Misdorp, W., de Jong, W.H., Ruitenberg, E.J. :
Immune reactivity in cattle with ocular squamous cell carcinoma after intralesional BCG immunotherapy. Cancer Immunol Immunother 22:87-94, 1986. Pubmed reference: 3719596.
Sloss, V., Smith, T.J., De Yi, G. :
Controlling ocular squamous cell carcinoma in Hereford cattle. Aust Vet J 63:248-51, 1986. Pubmed reference: 3790010.
1985 Dennis, M.W., Lueker, D.C., Kainer, R.A. :
Host response to bovine ocular squamous cell carcinoma. Am J Vet Res 46:1975-9, 1985. Pubmed reference: 4051302.
Heeney, J.L., Valli, V.E. :
Bovine ocular squamous cell carcinoma: an epidemiological perspective. Can J Comp Med 49:21-6, 1985. Pubmed reference: 3986677.
Kuchroo, V.K., Spradbrow, P.B. :
Tumour-associated antigens in bovine ocular squamous cell carcinoma: studies with sera from tumour-bearing animals. Vet Immunol Immunopathol 9:23-36, 1985. Pubmed reference: 3895721.
1982 [No authors listed] :
Immunotherapy of bovine eye cancer. Lancet 2:641, 1982. Pubmed reference: 6125783.
1980 Hamir, A.N., Parry, O.B. :
An abattoir study of bovine neoplasms with particular reference to ocular squamous cell carcinoma in Canada. Vet Rec 106:551-3, 1980. Pubmed reference: 7434525.
Spradbrow, P.B., Hoffmann, D. :
Bovine ocular squamous cell carcinoma Veterinary Bulletin 50:449-459, 1980.
1979 Kopecky, K.E., Pugh, G.W., Hughes, D.E., Booth, G.D., Cheville, N.F. :
Biological effect of ultraviolet radiation on cattle: bovine ocular squamous cell carcinoma. Am J Vet Res 40:1783-8, 1979. Pubmed reference: 525901.
1977 Nishimura, H., Frisch, J. :
Eye cancer and circumocular pigmentation in Bos taurus, Bos indicus and crossbred cattle. Australian Journal of Experimental Agriculture 17:709–711, 1977.
1976 Russell, W.C., Brinks, J.S., Kainer, R.A. :
Incidence and heritability of ocular squamous cell tumors in Hereford cattle. J Anim Sci 43:1156-62, 1976. Pubmed reference: 1002622.
1972 Cleaver, J.E., Kainer, R.A., Zelle, M.R. :
Ocular squamous cell carcinoma (cancer eye) in Hereford cattle: radiation repair processes and a comparison of cultured cells with xeroderma pigmentosum in man. Am J Vet Res 33:1131-6, 1972. Pubmed reference: 5022395.
1970 Anderson, D.E., Pope, L.S., Stephens, D. :
Nutrition and eye cancer in cattle. J Natl Cancer Inst 45:697-707, 1970. Pubmed reference: 5513499.
1964 Vogt, D.W., Anderson, D.E. :
Studies on bovine ocular squamous carcinoma ('cancer eye'). XV. Heritability of susceptibility Journal of Heredity 55:133-135, 1964. Pubmed reference: 14170403.
1963 Anderson, D.E. :
Effects of pigment on bovine ocular squamous carcinoma. Ann N Y Acad Sci 100:436-46, 1963. Pubmed reference: 14012826.
Vogt, D.W., Anderson, D.E., Easley, G.T. :
Studies on Bovine Ocular Squamous Carcinoma (“Cancer Eye") XIV. Heritabilities, Phenotypic Correlations, and Genetic Correlations Involving Corneoscleral and Lid Pigmentation. Journal of Animal Science 22:762–766, 1963.
1962 Lombard, C. :
[Heredity of "eye cancer" of cattle]. Bull Assoc Fr Etud Cancer 49:126-33, 1962. Pubmed reference: 14466394.
1960 Anderson, D.E. :
Studies on bovine ocular squamous carcinoma (cancer eye). V. Genetic aspects Journal of Heredity 51:51-58, 1960.
1959 French, G.T. :
A clinical and genetic study of eye cancer in Hereford cattle Australian Veterinary Journal 35:474-481, 1959.
1957 Anderson, D.E., Chambers, D. :
Genetic aspects of cancer eye in cattle Oklahoma State University Agricultural Experiment Station Miscellaneous Publications No MP 48:28-33, 1957.
Anderson, D.E., Chambers, D., Lush, J.L. :
Studies on bovine ocular squamous carcinoma (cancer eye). III. Inheritance of eyelid pigmentation Journal of Animal Science 16:1007-1016, 1957.
Anderson, W.A., Davis, C.L., Monlux, A.W. :
The diagnosis of squamous cell carcinoma of the eye (cancer eye) in cattle. Am J Vet Res 18:5-34, 1957. Pubmed reference: 13394813.
1956 Russell, W.O., Wynne, E.S., Loquvam, G.S. :
Studies on bovine ocular squamous carcinoma (cancer eye). I. Pathological anatomy and historical review. Cancer 9:1-52, 1956. Pubmed reference: 13284700.
1951 Russell, W.O., Loquvam, G.S. :
Squamous carcinoma of the conjunctiva and cornea of bovines ("cancer eye" of cattle). Am J Pathol 27:727-8, 1951. Pubmed reference: 14846954.
1950 Woodward, R.R., Knapp, B. :
The hereditary aspect of eye cancer in Hereford cattle. J Anim Sci 9:578-81, 1950. Pubmed reference: 14794577.
1948 Guilbert, H.R., Wahid, A. :
Observations on pigmentation of eyelids of Hereford cattle in relation to occurrence of ocular epitheliomas. J Anim Sci 7:426-9, 1948. Pubmed reference: 18891533.
1947 [No authors listed] :
EPITHELIOMA of the eye (cancer eye) in cattle cause for carcass condemnation. J Am Vet Med Assoc 111:384, 1947. Pubmed reference: 20268059.

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  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 15 Oct 2011
  • Changed by Frank Nicholas on 07 Dec 2012