OMIA:000836-9031 : Protoporphyria in Gallus gallus (chicken) |
In other species: taurine cattle
Categories: Integument (skin) phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 177000 (trait) , 612386 (gene)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Disease-related: yes
Key variant known: no
Cross-species summary: Protoporphyrin is the last intermediate in the seven-step biosynthesis of haem from aminolaevulinic acid (ALA). The conversion of protoporphyrin to haem is catalised by the enzyme ferrochelatase. Protoporphyria is a disorder resulting from the buildup of protoporphyrin (and the other five, earlier intermediates [porphyrins] in this pathway: see the entry for porphyria, unclassified), due to the lack of this enzyme. Protoporphyrin is extremely photoreactive. Because of this, photosensitivity is the main clinical sign of this disorder.
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000836-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 1995 | Shiozawa, M., Miyazawa, T., Koeda, T., Takahashi, M., Fujiwara, H. : |
| Protoporphyric disorder in livers of broiler chickens Journal of Veterinary Medical Science 57:549-551, 1995. Pubmed reference: 7548418. | |
| 1982 | Shoffner, R.N., Shuman, R., Otis, J.S., Bitgood, J.J., Garwood, V., Lowe, P. : |
| The effect of a protoporphyrin mutant on some economic traits of the chicken Poultry Science 61:817-820, 1982. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005