OMIA 000836-9031 : Protoporphyria in Gallus gallus
In other species: cattle Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 177000 (trait) , 612386 (gene) Mendelian trait/disorder: yes Considered a defect: yes Key variant known: no Cross-species summary: Protoporphyrin is the last intermediate in the seven-step biosynthesis of haem from aminolaevulinic acid (ALA). The conversion of protoporphyrin to haem is catalised by the enzyme ferrochelatase. Protoporphyria is a disorder resulting from the buildup of protoporphyrin (and the other five, earlier intermediates [porphyrins] in this pathway: see the entry for porphyria, unclassified), due to the lack of this enzyme. Protoporphyrin is extremely photoreactive. Because of this, photosensitivity is the main clinical sign of this disorder.
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1995||Shiozawa, M., Miyazawa, T., Koeda, T., Takahashi, M., Fujiwara, H. :|
|Protoporphyric disorder in livers of broiler chickens Journal of Veterinary Medical Science 57:549-551, 1995. Pubmed reference: 7548418.|
|1982||Shoffner, R.N., Shuman, R., Otis, J.S., Bitgood, J.J., Garwood, V., Lowe, P. :|
|The effect of a protoporphyrin mutant on some economic traits of the chicken Poultry Science 61:817-820, 1982.|
- Created by Frank Nicholas on 06 Sep 2005