OMIA 000938-9615 : Spinal dysraphism in Canis lupus familiaris |
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
NKX2-8 | NK2 homeobox 8 | Canis lupus familiaris | 8 | NC_051812.1 (15263403..15261532) | NKX2-8 | Homologene, Ensembl, NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Weimaraner | Spinal dysraphism | NKX2-8 | delins, small (<=20) | p.A150VfsX1 | 2013 | 23874236 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2013 | Safra, N., Bassuk, A.G., Ferguson, P.J., Aguilar, M., Coulson, R.L., Thomas, N., Hitchens, P.L., Dickinson, P.J., Vernau, K.M., Wolf, Z.T., Bannasch, D.L. : | |
Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. PLoS Genet 9:e1003646, 2013. Pubmed reference: 23874236. DOI: 10.1371/journal.pgen.1003646. | ||
2012 | Allett, B., Broome, M.R., Hager, D. : | |
MRI of a split cord malformation in a German shepherd dog. J Am Anim Hosp Assoc 48:344-51, 2012. Pubmed reference: 22843830. DOI: 10.5326/JAAHA-MS-5780. | ||
1995 | Ruberte, J., AƱor, S., Carretero, A., Vilafranca, M., Navarro, M., Mascort, J., Pumarola, M. : | |
Malformations of the vertebral bodies and the ribs associated to spinal dysraphism without spina bifida in a Pekingese dog. Zentralbl Veterinarmed A 42:307-13, 1995. Pubmed reference: 8578905. | ||
1992 | Bailey, C.S., Morgan, J.P. : | |
Congenital spinal malformations. Vet Clin North Am Small Anim Pract 22:985-1015, 1992. Pubmed reference: 1641930. | ||
1991 | Vandenbroek, A.H.M., Else, R.W., Abercromby, R., France, M. : | |
Spinal Dysraphism in the Weimaraner Journal of Small Animal Practice 32:258-260, 1991. | ||
1982 | Engel, H.N., Draper, D.D. : | |
Comparative prenatal development of the spinal cord in normal and dysraphic dogs: fetal stage. Am J Vet Res 43:1735-43, 1982. Pubmed reference: 6756222. | ||
Engel, H.N., Draper, D.D. : | ||
Comparative prenatal development of the spinal cord in normal and dysraphic dogs: embryonic stage. Am J Vet Res 43:1729-34, 1982. Pubmed reference: 6756221. | ||
1976 | Draper, D.D., Kluge, J.P., Millerw, J. : | |
Clinical and pathological aspects of spinal dysraphism in dogs. Thessaloniki 1:134-137, 1976. | ||
1974 | Neufeld, J.L., Little, P.B. : | |
Spinal dysraphism in a Dalmatian dog. Can Vet J 15:335-6, 1974. Pubmed reference: 4434313. | ||
1973 | Klaus, B. : | |
[Picture report. Spinal dysraphism in a German shepherd]. Berl Munch Tierarztl Wochenschr 86:95, 1973. Pubmed reference: 4732250. | ||
1972 | Confer, A.W., Ward, B.C. : | |
Spinal dysraphism: a congenital myelodysplasia in the Weimaraner Journal of the American Veterinary Medical Association 160:1423-1426, 1972. Pubmed reference: 5023160. | ||
1967 | Geib, L.W., Bistner, S.I. : | |
Spinal cord dysraphism in a dog. J Am Vet Med Assoc 150:618-20, 1967. Pubmed reference: 5339905. | ||
1965 | Foster, S.J. : | |
A case of sternal dysraphism and two cases of suspected congenital diaphragmatic hernia in the dog. Vet Rec 77:1112-4, 1965. Pubmed reference: 5318050. | ||
McGrath, J.T. : | ||
Spinal dysraphism in the dog, with comments on syringomylia Pathologia Veterinaria 2:1-36 (Supplement), 1965. Pubmed reference: 5893238. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 19 Aug 2013