OMIA 001022-9913 : Twinning in Bos taurus

In other species: horse ,

Mendelian trait/disorder: no

Considered a defect: no

Key variant known: no

Species-specific description: see also: OMIA 001943-9913 : Fecundity, generic in Bos taurus

Mapping: Widmer et al. (2021) "identified a major QTL on chromosome 11 for maternal multiple birth that explains ~ 16% of the total genetic variance. Using a haplotype-based approach, this QTL was fine-mapped to a 70-kb window on chromosome 11 between 31.00 and 31.07 Mb that harbors two functional candidate genes (LHCGR and FSHR)."

Molecular basis: Widmer et al. (2021): "Analysis of whole-genome sequence data by linkage-disequilibrium estimation revealed a regulatory variant in the 5'-region of LHCGR as a possible candidate causal variant for the identified major QTL."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Widmer, S., Seefried, F.R., von Rohr, P., Häfliger, I.M., Spengeler, M., Drögemüller, C. :
A major QTL at the LHCGR/FSHR locus for multiple birth in Holstein cattle. Genet Sel Evol 53:57, 2021. Pubmed reference: 34217202. DOI: 10.1186/s12711-021-00650-1.
1992 Beerepoot, G.M.M., Dykhuizen, A.A., Nielen, M., Schukken, Y.H. :
The Economics of Naturally Occurring Twinning in Dairy Cattle Journal of Dairy Science 75:1044-1051, 1992. Pubmed reference: 1578019.
Morris, C.A., Day, A.M., Amyes, N.C., Hurford, A.P. :
Ovulation and Calving Data from a Herd Selected for Twin Calving New Zealand Journal of Agricultural Research 35:379-391, 1992.
1991 Derose, E.P., Wilton, J.W. :
Productivity and Profitability of Twin Births in Beef Cattle Journal of Animal Science 69:3085-3093, 1991. Pubmed reference: 1894545.
Eddy, R.G., Davies, O., David, C. :
An Economic Assessment of Twin Births in British Dairy Herds Veterinary Record 129:526-529, 1991. Pubmed reference: 1788917.
Farquharson, R.J., Griffith, G.R. :
The Potential Economic Returns to the Australian Beef Industry from a New Twinning Technology Agricultural Systems 36:79-103, 1991.
Grobet, L., Charlier, C., Hanset, R. :
DNA Fingerprints and Leucochimerism in Bovine Dizygotic Twins Annales de Medecine Veterinaire 135:353-360, 1991.
Morris, C.A., Foulley, J.L. :
A Comparison of Genetic Data from New-Zealand and France on Twin Calving in Cattle Genetics Selection Evolution 23:345-350, 1991.
Taylor, S.C.S., Murray, J.I. :
Discriminating Between Monozygotic and Dizygotic Cattle Twins Journal of Animal Breeding and Genetics - Zeitschrift Fur Tierzuchtung und Zuchtungsbiologie 108:321-329, 1991.
1990 Gregory, K.E., Echternkamp, S.E., Dickerson, G.E., Cundiff, L.V., Koch, R.M., Vanvleck, L.D. :
Twinning in Cattle .1. Foundation Animals and Genetic and Environmental Effects on Twinning Rate Journal of Animal Science 68:1867-1876, 1990. Pubmed reference: 2384380.
Gregory, K.E., Echternkamp, S.E., Dickerson, G.E., Cundiff, L.V., Koch, R.M., Vanvleck, L.D. :
Twinning in Cattle .3. Effects of Twinning on Dystocia, Reproductive Traits, Calf Survival, Calf Growth and Cow Productivity Journal of Animal Science 68:3133-3144, 1990. Pubmed reference: 2254192.
Maijala, K., Osva, A. :
Genetic Correlations of Twinning Frequency with Other Economic Traits in Dairy Cattle Journal of Animal Breeding and Genetics-Zeitschrift Fur Tierzuchtung und Zuchtungsbiologie 107:7-15, 1990.
Morris, C.A., Day, A.M. :
Genetics and Physiology Studies of Cows in a Twin Breeding Experiment Journal of Animal Breeding and Genetics-Zeitschrift Fur Tierzuchtung und Zuchtungsbiologie 107:2-6, 1990.
Morris, C.A., Day, A.M. :
Effects of Dam and Sire Group on the Propensity for Twin Calving in Cattle Animal Production 51:481-488, 1990.
Ron, M., Ezra, E., Weller, J.I. :
Genetic Analysis of Twinning Rate in Israeli Holstein Cattle Genetics Selection Evolution 22:349-359, 1990.
Stolzenburg, U., Schonmuth, G. :
Selection Experiment for Twinning Rate in Dairy Cattle Journal of Animal Breeding and Genetics-Zeitschrift Fur Tierzuchtung und Zuchtungsbiologie 107:16-31, 1990.
Stolzenburg, U., Schonmuth, G. :
Selection of Bulls for Twinning Journal of Animal Breeding and Genetics-Zeitschrift Fur Tierzuchtung und Zuchtungsbiologie 107:32-42, 1990.
1989 Gorlich, L., Wollert, J., Karge, U., Heine, C. :
Effect of Twinning on Calving and Growth Parameters in Beef Calves Archiv Fur Tierzucht-Archives of Animal Breeding 32:535-543, 1989.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 20 Aug 2020
  • Changed by Imke Tammen2 on 08 Aug 2021