OMIA 001040-9615 : Ventricular arrhythmias and sudden death in Canis lupus familiaris

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: Brisbin et al. (2011) implicated a region in each of chromsome CFA6 and CFA11 in a pedigree of German Shepherd dogs.

Breeds: Boxer, German Shepherd Dog.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2011 Brisbin, A., Cruickshank, J., Moïse, N.S., Gunn, T., Bustamante, C.D., Mezey, J.G. :
Fast, exact linkage analysis for categorical traits on arbitrary pedigree designs. Genet Epidemiol 35:371-80, 2011. Pubmed reference: 21520271. DOI: 10.1002/gepi.20585.
Pariaut, R., Saelinger, C., Queiroz-Williams, P., Strickland, K.N., Marshall, H.C. :
Implantable cardioverter-defibrillator in a German shepherd dog with ventricular arrhythmias. J Vet Cardiol 13:203-10, 2011. Pubmed reference: 21849269. DOI: 10.1016/j.jvc.2011.04.006.
2010 Gelzer, A.R., Kraus, M.S., Rishniw, M., Hemsley, S.A., Moïse, N.S. :
Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study. J Vet Cardiol 12:93-106, 2010. Pubmed reference: 20663731. DOI: 10.1016/j.jvc.2010.06.001.
2009 Cruickshank, J., Quaas, R.L., Li, J., Hemsley, S., Gunn, T.M., Moïse, N.S. :
Genetic analysis of ventricular arrhythmia in young German Shepherd Dogs. J Vet Intern Med 23:264-70, 2009. Pubmed reference: 19210315. DOI: 10.1111/j.1939-1676.2009.0265.x.
2008 Pariaut, R., Moïse, N.S., Koetje, B.D., Flanders, J.A., Hemsley, S.A., Farver, T.B., Gilmour, R.F., Gelzer, A.R., Kraus, M.S., Otani, N.F. :
Lidocaine converts acute vagally associated atrial fibrillation to sinus rhythm in German Shepherd dogs with inherited arrhythmias. J Vet Intern Med 22:1274-82, 2008. Pubmed reference: 18798790. DOI: 10.1111/j.1939-1676.2008.0188.x.
2007 Oxford, E.M., Everitt, M., Coombs, W., Fox, P.R., Kraus, M., Gelzer, A.R., Saffitz, J., Taffet, S.M., Moïse, N.S., Delmar, M. :
Molecular composition of the intercalated disc in a spontaneous canine animal model of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm 4:1196-205, 2007. Pubmed reference: 17765621. DOI: 10.1016/j.hrthm.2007.05.025.
2005 Gelzer, A.R., Moïse, N.S., Koller, M.L. :
Defibrillation of German shepherds with inherited ventricular arrhythmias and sudden death. J Vet Cardiol 7:97-107, 2005. Pubmed reference: 19083325. DOI: 10.1016/j.jvc.2005.09.006.
Protas, L., Sosunov, E.A., Anyukhovsky, E.P., Moïse, N.S., Rosen, M.R., Robinson, R.B. :
Regional dispersion of L-type calcium current in ventricular myocytes of German shepherd dogs with lethal cardiac arrhythmias. Heart Rhythm 2:172-6, 2005. Pubmed reference: 15851292. DOI: 10.1016/j.hrthm.2004.10.041.
2004 Sosunov, E.A., Obreztchikova, M.N., Anyukhovsky, E.P., Moïse, N.S., Danilo, P., Robinson, R.B., Rosen, M.R. :
Mechanisms of alpha-adrenergic potentiation of ventricular arrhythmias in dogs with inherited arrhythmic sudden death. Cardiovasc Res 61:715-23, 2004. Pubmed reference: 14985068. DOI: 10.1016/j.cardiores.2003.12.025.
2003 Obreztchikova, M.N., Sosunov, E.A., Anyukhovsky, E.P., Moïse, N.S., Robinson, R.B., Rosen, M.R. :
Heterogeneous ventricular repolarization provides a substrate for arrhythmias in a German shepherd model of spontaneous arrhythmic death. Circulation 108:1389-94, 2003. Pubmed reference: 12939224. DOI: 10.1161/01.CIR.0000086461.86642.22.
2002 Kraus, M.S., Moïse, N.S., Rishniw, M., Dykes, N., Erb, H.N. :
Morphology of ventricular arrhythmias in the boxer as measured by 12-lead electrocardiography with pace-mapping comparison. J Vet Intern Med 16:153-8, 2002. Pubmed reference: 11899030.
Meurs, K.M., Spier, A.W., Wright, N.A., Atkins, C.E., DeFrancesco, T.C., Gordon, S.G., Hamlin, R.L., Keene, B.W., Miller, M.W., Moise, N.S. :
Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers. J Am Vet Med Assoc 221:522-7, 2002. Pubmed reference: 12184702.
2000 Merot, J., Probst, V., Debailleul, M., Gerlach, U., Moise, N.S., Le, Marec, H., Charpentier, F. :
Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: Abnormal response to potassium channel blockers Journal of the American College of Cardiology 36:939-947, 2000. Pubmed reference: 10987623.
Sosunov, E.A., Gainullin, R.Z., Moise, N.S., Steinberg, S.F., Danilo, P., Rosen, M.R. :
beta(1) and beta(2)-adrenergic receptor subtype effects in German shepherd dogs with inherited lethal ventricular arrhythmias Cardiovascular Research 48:211-219, 2000. Pubmed reference: 11054468.
1999 Meurs, K.M., Spier, A.W., Miller, M.W., Lehmkuhl, L., Towbin, J.A. :
Familial ventricular arrhythmias in boxers Journal of Veterinary Internal Medicine 13:437-439, 1999. Pubmed reference: 10499727.
Sosunov, E.A., Anyukhovsky, E.P., Shvilkin, A., Hara, M., Steinberg, S.F., Danilo, P., Rosen, M.R., Moise, N.S., Merot, J., Probst, V., Charpentier, F., Legeay, Y., Le, Marec, H. :
Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death Cardiovascular Research 42:65-79, 1999. Pubmed reference: 10434997.
1997 Dae, M.W., Lee, R.J., Ursell, P.C., Chin, M.C., Stillson, C.A., Moise, N.S. :
Heterogeneous sympathetic innervation in german shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death Circulation 96:1337-1342, 1997. Pubmed reference: 9286967.
Freeman, L.C., Pacioretty, L.M., Moise, N.S., Kass, R.S., Gilmour, R.F. :
Decreased density of Ito in left ventricular myocytes from German shepherd dogs with inherited arrhythmias. J Cardiovasc Electrophysiol 8:872-83, 1997. Pubmed reference: 9261713.
Moïse, N.S., Gilmour, R.F., Riccio, M.L. :
An animal model of spontaneous arrhythmic death. J Cardiovasc Electrophysiol 8:98-103, 1997. Pubmed reference: 9116974.
Moïse, N.S., Riccio, M.L., Kornreich, B., Flahive, W.J., Gilmour, R.F. :
Age dependence of the development of ventricular arrhythmias in a canine model of sudden cardiac death. Cardiovasc Res 34:483-92, 1997. Pubmed reference: 9231031.
1996 Gilmour, R.F., Moise, N.S. :
Triggered activity as a mechanism for inherited ventricular arrhythmias in German Shepherd dogs Journal of the American College of Cardiology 27:1526-1533, 1996. Pubmed reference: 8626969.
Moise, N.S., Moon, P.F., Flahive, W.J., Brittain, D., Pride, H.P., Lewis, B.A., Zipes, D.P., Lee, R.J., Gilmour, R.F. :
Phenylephrine-induced ventricular arrhythmias in dogs with inherited sudden death Journal of Cardiovascular Electrophysiology 7:217-230, 1996. Pubmed reference: 8867296.
Moïse, N.S., Brittain, D.D., Flahive, W.J., Riccio, M.L., Ernst, R.S., Scarlett, J., Mohammed, H.O., Morrison, A.R., Gilmour, R.F. :
Relationship of ventricular tachycardia to sleep/wakefulness in a model of sudden cardiac death. Pediatr Res 40:344-50, 1996. Pubmed reference: 8827788.
1994 Moise, N.S., Meyers-Wallen, V., Flahive, W.J., Valentine, B.A., Scarlett, J.M., Brown, C.A., Chavkin, M.J., Dugger, D.A., Renaudfarrell, S., Kornreich, B., Schoenborn, W.C., Sparks, J.R., Gilmour, R.F. :
Inherited ventricular arrhythmias and sudden death in German Shepherd dogs Journal of the American College of Cardiology 24:233-243, 1994. Pubmed reference: 8006271.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 03 Oct 2011